In:
Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-5-19)
Abstract:
Squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are the most common histological types of cervical cancer (CC). The worse prognosis of ADC cases highlights the need for better molecular characterization regarding differences between these CC types. RNA-Seq analysis of seven SCC and three ADC human papillomavirus 16-positive samples and the comparison with public data from non-tumoral human papillomavirus-negative cervical tissue samples revealed pathways exclusive to each histological type, such as the epithelial maintenance in SCC and the maturity-onset diabetes of the young (MODY) pathway in ADC. The transcriptional regulatory network analysis of cervical SCC samples unveiled a set of six transcription factor (TF) genes with the potential to positively regulate long non-coding RNA genes DSG1-AS1, CALML3-AS1, IGFL2-AS1 , and TINCR . Additional analysis revealed a set of MODY TFs regulated in the sequence predicted to be repressed by miR-96-5p or miR-28-3p in ADC. These microRNAs were previously described to target LINC02381, which was predicted to be positively regulated by two MODY TFs upregulated in cervical ADC. Therefore, we hypothesize LINC02381 might act by decreasing the levels of miR-96-5p and miR-28-3p, promoting the MODY activation in cervical ADC. The novel TF networks here described should be explored for the development of more efficient diagnostic tools.
Type of Medium:
Online Resource
ISSN:
2234-943X
DOI:
10.3389/fonc.2021.626187
DOI:
10.3389/fonc.2021.626187.s001
DOI:
10.3389/fonc.2021.626187.s002
DOI:
10.3389/fonc.2021.626187.s003
DOI:
10.3389/fonc.2021.626187.s004
DOI:
10.3389/fonc.2021.626187.s005
DOI:
10.3389/fonc.2021.626187.s006
DOI:
10.3389/fonc.2021.626187.s007
DOI:
10.3389/fonc.2021.626187.s008
DOI:
10.3389/fonc.2021.626187.s009
DOI:
10.3389/fonc.2021.626187.s010
DOI:
10.3389/fonc.2021.626187.s011
DOI:
10.3389/fonc.2021.626187.s012
DOI:
10.3389/fonc.2021.626187.s013
DOI:
10.3389/fonc.2021.626187.s014
DOI:
10.3389/fonc.2021.626187.s015
DOI:
10.3389/fonc.2021.626187.s016
DOI:
10.3389/fonc.2021.626187.s017
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2649216-7
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