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  • 1
    In: Molecular Nutrition & Food Research, Wiley, Vol. 61, No. 8 ( 2017-08)
    Abstract: Nasturtium plants contain the glucosinolate glucotropaeolin and its corresponding breakdown product benzyl isothiocyanate (BITC), the latter being intensively studied with regard to cancer chemoprevention and anti‐inflammatory properties. In addition, recent research has shown that isothiocyanates are able to activate the release of several gut hormones in vitro and in rodent studies. Here, we tested the effects of a dietary nasturtium administration on circulating levels of gut hormones in humans. Methods and results Metabolically healthy males ( n = 15) received a single oral dose of 10 g freeze‐dried nasturtium leaf material suspended in water or only water (control). Blood samples were taken every hour and serum concentrations of insulin, C‐peptide, glucagon‐like peptide 1 (GLP‐1), glucose‐dependent insulinotropic peptide (GIP), and peptide (PYY) were analyzed. Oral nasturtium intake resulted in an increased release of PYY over a time period of 6 h whereas circulating levels of other hormones were not changed. Conclusion Given the finding that nasturtium consumption enhances secretion of PYY, a key hormone involved in energy regulation, special diets containing nasturtium, or supplementation with nasturtium or BITC might be considered in the treatment of obesity.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2010
    In:  Public Health Nutrition Vol. 13, No. 1 ( 2010-01), p. 32-37
    In: Public Health Nutrition, Cambridge University Press (CUP), Vol. 13, No. 1 ( 2010-01), p. 32-37
    Abstract: Sometimes the suspicion is put forward that nutrition students show more disordered eating patterns, which may be among the motivating factors to study nutrition. At the same time, it is not clear whether the students’ increasing knowledge about diet and nutrition is associated with a more healthy eating behaviour or with an unhealthy obsession with food choices. Design Cross-sectional comparison of nutrition students from German universities during the first year of their studies ( n 123) and during higher semesters ( n 96), with a control group from other study programmes ( n 68 and n 46, respectively). Dietary restraint, disinhibition, the tendency towards orthorexia nervosa and healthy food choices were assessed using a questionnaire. Results Nutrition students showed higher levels of dietary restraint than the control group. Disinhibition and orthorexia nervosa did not differ between nutrition students and controls. Orthorexic tendencies were lower in the more advanced nutrition students. Healthy food choices did not differ among students in the first year. More advanced nutrition students showed healthier food choices, whereas the corresponding controls showed slightly more unhealthy food choices. Conclusions Nutrition students, more than other students, tend to restrict their food intake in order to control their weight, but they do not have more disturbed or disordered eating patterns than other students. Moreover, during the course of their studies, they adopt slightly more healthy food choices and decrease their tendency to be obsessive in their eating behaviour.
    Type of Medium: Online Resource
    ISSN: 1368-9800 , 1475-2727
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2010
    detail.hit.zdb_id: 2016337-X
    SSG: 21
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  • 3
    In: Molecular Nutrition & Food Research, Wiley, Vol. 60, No. 3 ( 2016-03), p. 652-660
    Abstract: Benzyl isothiocyanate (BITC), which occurs in Brassicales, has demonstrated chemopreventive potency and cancer treatment properties in cell and animal studies. However, fate of BITC in human body is not comprehensively studied. Therefore, the present human intervention study investigates the metabolism of the glucosinolate (GSL) glucotropaeolin and its corresponding BITC metabolites. Analyzing BITC metabolites in plasma and urine should reveal insights about resorption, metabolism, and excretion. Methods and results Fifteen healthy men were randomly recruited for a cross‐over study and consumed 10 g freeze‐dried Indian cress as a liquid preparation containing 1000 μmol glucotropaeolin. Blood and urine samples were taken at several time points and investigated by LC‐ESI‐MS/MS after sample preparation using SPE. Plasma contained high levels of BITC‐glutathione (BITC‐GSH), BITC‐cysteinylglycine (BITC‐CysGly), and BITC‐ N ‐acetyl‐L‐cysteine (BITC‐NAC) 1–5 h after ingestion, with BITC‐CysGly appearing as the main metabolite. Compared to human plasma, the main urinary metabolites were BITC‐NAC and BITC‐Cys, determined 4–6 h after ingestion. Conclusion This study confirms that consumption of Indian cress increases the concentration of BITC metabolites in human plasma and urine. The outcome of this human intervention study supports clinical research dealing with GSL‐containing innovative food products or pharmaceutical preparations.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2013
    In:  Analytical and Bioanalytical Chemistry Vol. 405, No. 23 ( 2013-9), p. 7427-7436
    In: Analytical and Bioanalytical Chemistry, Springer Science and Business Media LLC, Vol. 405, No. 23 ( 2013-9), p. 7427-7436
    Type of Medium: Online Resource
    ISSN: 1618-2642 , 1618-2650
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 1459122-4
    detail.hit.zdb_id: 2071767-2
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2012
    In:  Public Health Nutrition Vol. 15, No. 10 ( 2012-10), p. 1932-1940
    In: Public Health Nutrition, Cambridge University Press (CUP), Vol. 15, No. 10 ( 2012-10), p. 1932-1940
    Abstract: The potential effects of four interventions to improve iodine intakes of six New Zealand population groups are assessed. Design A model was developed to estimate iodine intake when (i) bread is manufactured with or without iodized salt, (ii) recommended foods are consumed to augment iodine intake, (iii) iodine supplementation as recommended for pregnant women is taken and (iv) the level of iodization for use in bread manufacture is doubled from 25–65 mg to 100 mg iodine/kg salt. Setting New Zealanders have low and decreasing iodine intakes and low iodine status. Predictive modelling is a useful tool to assess the likely impact, and potential risk, of nutrition interventions. Subjects Food consumption information was sourced from 24 h diet recall records for 4576 New Zealanders aged over 5 years. Results Most consumers (73–100 %) are predicted to achieve an adequate iodine intake when salt iodized at 25–65 mg iodine/kg salt is used in bread manufacture, except in pregnant females of whom 37 % are likely to meet the estimated average requirement. Current dietary advice to achieve estimated average requirements is challenging for some consumers. Pregnant women are predicted to achieve adequate but not excessive iodine intakes when 150 μg of supplemental iodine is taken daily, assuming iodized salt in bread. Conclusions The manufacture of bread with iodized salt and supplemental iodine for pregnant women are predicted to be effective interventions to lift iodine intakes in New Zealand. Current estimations of iodine intake will be improved with information on discretionary salt and supplemental iodine usage.
    Type of Medium: Online Resource
    ISSN: 1368-9800 , 1475-2727
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2012
    detail.hit.zdb_id: 2016337-X
    SSG: 21
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