In:
Journal of Periodontology, Wiley, Vol. 89, No. 11 ( 2018-11), p. 1310-1317
Abstract:
The aim of this cross‐sectional study was to investigate clinical periodontal findings as well as prevalence of selected potentially periodontal pathogenic bacteria in patients with rheumatoid arthritis (RA) treated with different immunosuppressive rheumatic medications. Methods One hundred sixty‐eight patients with RA undergoing different immunosuppressive medications were included and divided into subgroups according to their medication, which was taken in the past 6 months, in detail, 1) non‐steroidal anti‐inflammatory drugs (NSAID) and glucocorticoids combined, and the following different disease modifying anti‐rheumatic drugs (DMARDs): 2) methotrexate (MTX), 3) leflunomide, 4) MTX and TNF‐α antagonists combined, 5) interleukin‐6 (IL‐6) antagonist, 6) MTX and rituximab combined, and 7) combination therapies of 〉 2 of these DMARDs. Periodontal examination consisted of papilla bleeding index (PBI), periodontal status with periodontal probing depth (PD), bleeding on probing (BOP), and clinical attachment loss (AL). Periodontitis was classified as none/mild, moderate, or severe. Samples obtained from gingival crevicular fluid were analyzed for presence of 11 periodontal pathogenic bacteria. Results Patients with MTX + TNF‐α antagonists therapy showed higher PBI and BOP values compared with leflunomide ( P 〈 0.01) and higher BOP than MTX + rituximab ( P = 0.02). Porphyromonas gingivalis ( P 〈 0.01), Treponema denticola ( P 〈 0.01), Fusobacterium nodatum ( P = 0.02) and Capnocytophaga species ( P = 0.05) was associated with medication subgroup, whereby post hoc testing confirmed singular differences for several medication subgroups. Conclusions RA medication is associated with periodontal inflammation, without differences in periodontal disease severity. Thereby, combination of MTX + TNF‐α shows an increased potential to periodontal inflammation. Additionally, several differences in prevalence of selected bacteria were detected.
Type of Medium:
Online Resource
ISSN:
0022-3492
,
1943-3670
DOI:
10.1002/jper.2018.89.issue-11
DOI:
10.1002/JPER.17-0616
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2040047-0
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