KOBV Portal

Hits per page

hits 1 - 10 | 666 hits

Sorting

Online Resource

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

Todd Milne, G. ; on behalf of the Ironwood team ; Sandner, Peter ; [et al.]

Springer Science and Business Media LLC ; 2017

In: BMC Pharmacology and Toxicology Vol. 18, No. S1 ( 2017-10)

add to watchlist on the watchlist

Details

In: BMC Pharmacology and Toxicology, Springer Science and Business Media LLC, Vol. 18, No. S1 ( 2017-10)

Type of Medium: Online Resource

ISSN: 2050-6511

URL: Article

DOI: 10.1186/s40360-017-0170-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2680259-4

SSG: 15,3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

Garcia-Closas, Montserrat ; The Gene ENvironmental Interaction and breast CAncer (GENICA) Network ; Couch, Fergus J ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Nature Genetics Vol. 45, No. 4 ( 2013-4), p. 392-398

add to watchlist on the watchlist

Details

In: Nature Genetics, Springer Science and Business Media LLC, Vol. 45, No. 4 ( 2013-4), p. 392-398

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.2561

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 1494946-5

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Agarwal, D ; kConFab Investigators ; Pineda, S ; [et al.]

Springer Science and Business Media LLC ; 2014

In: British Journal of Cancer Vol. 110, No. 4 ( 2014-2), p. 1088-1100

add to watchlist on the watchlist

Details

In: British Journal of Cancer, Springer Science and Business Media LLC, Vol. 110, No. 4 ( 2014-2), p. 1088-1100

Type of Medium: Online Resource

ISSN: 0007-0920 , 1532-1827

URL: Article

DOI: 10.1038/bjc.2013.769

RVK:

XA 33500

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2002452-6

detail.hit.zdb_id: 80075-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2

Orr, N. ; Dudbridge, F. ; Dryden, N. ; [et al.]

Oxford University Press (OUP) ; 2015

In: Human Molecular Genetics Vol. 24, No. 10 ( 2015-05-15), p. 2966-2984

add to watchlist on the watchlist

Details

In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 24, No. 10 ( 2015-05-15), p. 2966-2984

Type of Medium: Online Resource

ISSN: 0964-6906 , 1460-2083

URL: Article

DOI: 10.1093/hmg/ddv035

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2015

detail.hit.zdb_id: 1474816-2

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

Deere, Jesse D. ; Carroll, Timothy D. ; Dutra, Joseph ; [et al.]

American Society for Microbiology ; 2021

In: Microbiology Spectrum Vol. 9, No. 3 ( 2021-12-22)

add to watchlist on the watchlist

Details

In: Microbiology Spectrum, American Society for Microbiology, Vol. 9, No. 3 ( 2021-12-22)

Abstract: Human clinical studies investigating use of convalescent plasma (CP) for treatment of coronavirus disease 2019 (COVID-19) have produced conflicting results. Outcomes in these studies may vary at least partly due to different timing of CP administration relative to symptom onset. The mechanisms of action of CP include neutralizing antibodies but may extend beyond virus neutralization to include normalization of blood clotting and dampening of inflammation. Unresolved questions include the minimum therapeutic titer in the CP units or CP recipient as well as the optimal timing of administration. Here, we show that treatment of macaques with CP within 24 h of infection does not reduce viral shedding in nasal or lung secretions compared to controls and does not detectably improve any clinical endpoint. We also demonstrate that CP administration does not impact viral sequence diversity in vivo , although the selection of a viral sequence variant in both macaques receiving normal human plasma was suggestive of immune pressure. Our results suggest that CP, administered to medium titers, has limited efficacy, even when given very early after infection. Our findings also contribute information important for the continued development of the nonhuman primate model of COVID-19. These results should inform interpretation of clinical studies of CP in addition to providing insights useful for developing other passive immunotherapies and vaccine strategies. IMPORTANCE Antiviral treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain very limited. One treatment that was explored beginning early in the pandemic (and that is likely to be tested early in future pandemics) is plasma collected from people who have recovered from coronavirus disease 2019 (COVID-19), known as convalescent plasma (CP). We tested if CP reduces viral shedding or disease in a nonhuman primate model. Our results demonstrate that administration of CP 1 day after SARS-CoV-2 infection had no significant impact on viral loads, clinical disease, or sequence diversity, although treatment with normal human plasma resulted in selection of a specific viral variant. Our results demonstrate that passive immunization with CP, even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.

Type of Medium: Online Resource

ISSN: 2165-0497

URL: Article

DOI: 10.1128/Spectrum.01397-21

Language: English

Publisher: American Society for Microbiology

Publication Date: 2021

detail.hit.zdb_id: 2807133-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Spurdle, Amanda B ; EMBRACE Group ; Couch, Fergus J ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Breast Cancer Research Vol. 16, No. 6 ( 2014-12)

add to watchlist on the watchlist

Details

In: Breast Cancer Research, Springer Science and Business Media LLC, Vol. 16, No. 6 ( 2014-12)

Type of Medium: Online Resource

ISSN: 1465-542X

URL: Article

DOI: 10.1186/s13058-014-0474-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2041618-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Antigenic Relationship Between Echovirus Types 29 and 32.

Schmidt, N. J. ; Ho, H. H. ; King, C. J. ; [et al.]

SAGE Publications ; 1964

In: Experimental Biology and Medicine Vol. 116, No. 1 ( 1964-05-01), p. 77-80

add to watchlist on the watchlist

Details

In: Experimental Biology and Medicine, SAGE Publications, Vol. 116, No. 1 ( 1964-05-01), p. 77-80

Type of Medium: Online Resource

ISSN: 1535-3702 , 1535-3699

URL: Article

DOI: 10.3181/00379727-116-29164

Language: English

Publisher: SAGE Publications

Publication Date: 1964

detail.hit.zdb_id: 2020856-X

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques

Van Rompay, Koen K. A. ; Olstad, Katherine J. ; Sammak, Rebecca L. ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Pathogens Vol. 17, No. 7 ( 2021-7-6), p. e1009688-

add to watchlist on the watchlist

Details

In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2021-7-6), p. e1009688-

Abstract: There is an urgent need for effective therapeutic interventions against SARS-CoV-2, including new variants that continue to arise. Neutralizing monoclonal antibodies have shown promise in clinical studies. We investigated the therapeutic efficacy of a combination of two potent monoclonal antibodies, C135-LS and C144-LS that carry half-life extension mutations, in the rhesus macaque model of COVID-19. Twelve young adult macaques (three groups of four animals) were inoculated intranasally and intra-tracheally with a high dose of SARS-CoV-2 and 24 hours later, treated intravenously with a high (40 mg/kg) or low (12 mg/kg) dose of the C135-LS and C144-LS antibody combination, or a control monoclonal antibody. Animals were monitored for 7 days. Compared to the control animals, animals treated with either dose of the anti-SARS-CoV-2 antibodies showed similarly improved clinical scores, lower levels of virus replication in upper and lower respiratory tract, and significantly reduced interstitial pneumonia, as measured by comprehensive lung histology. In conclusion, this study provides proof-of-concept in support of further clinical development of these monoclonal antibodies against COVID-19 during early infection.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1009688

DOI: 10.1371/journal.ppat.1009688.g001

DOI: 10.1371/journal.ppat.1009688.g002

DOI: 10.1371/journal.ppat.1009688.g003

DOI: 10.1371/journal.ppat.1009688.g004

DOI: 10.1371/journal.ppat.1009688.g005

DOI: 10.1371/journal.ppat.1009688.g006

DOI: 10.1371/journal.ppat.1009688.g007

DOI: 10.1371/journal.ppat.1009688.s001

DOI: 10.1371/journal.ppat.1009688.s002

DOI: 10.1371/journal.ppat.1009688.s003

DOI: 10.1371/journal.ppat.1009688.s004

DOI: 10.1371/journal.ppat.1009688.s005

DOI: 10.1371/journal.ppat.1009688.s006

DOI: 10.1371/journal.ppat.1009688.s007

DOI: 10.1371/journal.ppat.1009688.s008

DOI: 10.1371/journal.ppat.1009688.s009

DOI: 10.1371/journal.ppat.1009688.s010

DOI: 10.1371/journal.ppat.1009688.s011

DOI: 10.1371/journal.ppat.1009688.s012

DOI: 10.1371/journal.ppat.1009688.s013

DOI: 10.1371/journal.ppat.1009688.s014

DOI: 10.1371/journal.ppat.1009688.s015

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2205412-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

The role of genetic breast cancer susceptibility variants as prognostic factors

Fasching, Peter A. ; Pharoah, Paul D.P. ; Cox, Angela ; [et al.]

Oxford University Press (OUP) ; 2012

In: Human Molecular Genetics Vol. 21, No. 17 ( 2012-09-01), p. 3926-3939

add to watchlist on the watchlist

Details

In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 21, No. 17 ( 2012-09-01), p. 3926-3939

Type of Medium: Online Resource

ISSN: 1460-2083 , 0964-6906

URL: Article

DOI: 10.1093/hmg/dds159

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2012

detail.hit.zdb_id: 1474816-2

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation

Van Rompay, Koen K. A. ; Olstad, Katherine J. ; Sammak, Rebecca L. ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Pathogens Vol. 18, No. 4 ( 2022-4-20), p. e1009925-

add to watchlist on the watchlist

Details

In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 18, No. 4 ( 2022-4-20), p. e1009925-

Abstract: Early in the SARS-CoV-2 pandemic, there was a high level of optimism based on observational studies and small controlled trials that treating hospitalized patients with convalescent plasma from COVID-19 survivors (CCP) would be an important immunotherapy. However, as more data from controlled trials became available, the results became disappointing, with at best moderate evidence of efficacy when CCP with high titers of neutralizing antibodies was used early in infection. To better understand the potential therapeutic efficacy of CCP, and to further validate SARS-CoV-2 infection of macaques as a reliable animal model for testing such strategies, we inoculated 12 adult rhesus macaques with SARS-CoV-2 by intratracheal and intranasal routes. One day later, 8 animals were infused with pooled human CCP with a high titer of neutralizing antibodies (RVPN NT 50 value of 3,003), while 4 control animals received normal human plasma. Animals were monitored for 7 days. Animals treated with CCP had detectable but low levels of antiviral antibodies after infusion. In comparison to the control animals, CCP-treated animals had similar levels of viral RNA in upper and lower respiratory tract secretions, similar detection of viral RNA in lung tissues by in situ hybridization, but lower amounts of infectious virus in the lungs. CCP-treated animals had a moderate, but statistically significant reduction in interstitial pneumonia, as measured by comprehensive lung histology. Thus overall, therapeutic benefits of CCP were marginal and inferior to results obtained earlier with monoclonal antibodies in this animal model. By highlighting strengths and weaknesses, data of this study can help to further optimize nonhuman primate models to provide proof-of-concept of intervention strategies, and guide the future use of convalescent plasma against SARS-CoV-2 and potentially other newly emerging respiratory viruses.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1009925

DOI: 10.1371/journal.ppat.1009925.g001

DOI: 10.1371/journal.ppat.1009925.g002

DOI: 10.1371/journal.ppat.1009925.g003

DOI: 10.1371/journal.ppat.1009925.g004

DOI: 10.1371/journal.ppat.1009925.g005

DOI: 10.1371/journal.ppat.1009925.g006

DOI: 10.1371/journal.ppat.1009925.g007

DOI: 10.1371/journal.ppat.1009925.g008

DOI: 10.1371/journal.ppat.1009925.s001

DOI: 10.1371/journal.ppat.1009925.s002

DOI: 10.1371/journal.ppat.1009925.s003

DOI: 10.1371/journal.ppat.1009925.s004

DOI: 10.1371/journal.ppat.1009925.s005

DOI: 10.1371/journal.ppat.1009925.s006

DOI: 10.1371/journal.ppat.1009925.s007

DOI: 10.1371/journal.ppat.1009925.s008

DOI: 10.1371/journal.ppat.1009925.s009

DOI: 10.1371/journal.ppat.1009925.s010

DOI: 10.1371/journal.ppat.1009925.s011

DOI: 10.1371/journal.ppat.1009925.s012

DOI: 10.1371/journal.ppat.1009925.s013

DOI: 10.1371/journal.ppat.1009925.s014

DOI: 10.1371/journal.ppat.1009925.s015

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2205412-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 666 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg