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Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo

Rich Abbott ; Thomas D. Abbott ; Sheelu Abraham ; [et al.]

Elsevier BV ; 2021

In: SoftwareX Vol. 13 ( 2021-01), p. 100658-

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In: SoftwareX, Elsevier BV, Vol. 13 ( 2021-01), p. 100658-

Type of Medium: Online Resource

ISSN: 2352-7110

URL: Article

DOI: 10.1016/j.softx.2021.100658

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2819369-6

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World Congress Integrative Medicine & Health 2017: Part one : Berlin, Germany. 3-5 May 2017

Brinkhaus, Benno ; Falkenberg, Torkel ; Haramati, Aviad ; [et al.]

Springer Science and Business Media LLC ; 2017

In: BMC Complementary and Alternative Medicine Vol. 17, No. S1 ( 2017-6)

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In: BMC Complementary and Alternative Medicine, Springer Science and Business Media LLC, Vol. 17, No. S1 ( 2017-6)

Type of Medium: Online Resource

ISSN: 1472-6882

URL: Article

DOI: 10.1186/s12906-017-1782-4

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2050429-9

detail.hit.zdb_id: 3037610-5

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Responsiveness of multiple patient-reported outcome measures for acute postsurgical pain: primary results from the international multi-centre PROMPT NIT-1 study

Vollert, Jan ; Segelcke, Daniel ; Weinmann, Claudia ; [et al.]

Elsevier BV ; 2023

In: British Journal of Anaesthesia ( 2023-11)

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In: British Journal of Anaesthesia, Elsevier BV, ( 2023-11)

Type of Medium: Online Resource

ISSN: 0007-0912

URL: Article

DOI: 10.1016/j.bja.2023.10.020

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2011968-9

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Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network

Fluschnik, Nina ; Geelhoed, Bastiaan ; Becher, Peter Moritz ; [et al.]

Elsevier BV ; 2021

In: International Journal of Cardiology Vol. 331 ( 2021-05), p. 57-62

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In: International Journal of Cardiology, Elsevier BV, Vol. 331 ( 2021-05), p. 57-62

Type of Medium: Online Resource

ISSN: 0167-5273

URL: Article

DOI: 10.1016/j.ijcard.2021.02.002

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 1500478-8

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Adherence to Mediterranean diet, high-sensitive C-reactive protein, and severity of coronary artery disease: Contemporary data from the INTERCATH cohort

Waldeyer, Christoph ; Brunner, Fabian J. ; Braetz, Julian ; [et al.]

Elsevier BV ; 2018

In: Atherosclerosis Vol. 275 ( 2018-08), p. 256-261

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In: Atherosclerosis, Elsevier BV, Vol. 275 ( 2018-08), p. 256-261

Type of Medium: Online Resource

ISSN: 0021-9150

URL: Article

DOI: 10.1016/j.atherosclerosis.2018.06.877

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1499887-7

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Continuous-variable protocol for oblivious transfer in the noisy-storage model

Furrer, Fabian ; Gehring, Tobias ; Schaffner, Christian ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Nature Communications Vol. 9, No. 1 ( 2018-04-13)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2018-04-13)

Abstract: Cryptographic protocols are the backbone of our information society. This includes two-party protocols which offer protection against distrustful players. Such protocols can be built from a basic primitive called oblivious transfer. We present and experimentally demonstrate here a quantum protocol for oblivious transfer for optical continuous-variable systems, and prove its security in the noisy-storage model. This model allows us to establish security by sending more quantum signals than an attacker can reliably store during the protocol. The security proof is based on uncertainty relations which we derive for continuous-variable systems, that differ from the ones used in quantum key distribution. We experimentally demonstrate in a proof-of-principle experiment the proposed oblivious transfer protocol for various channel losses by using entangled two-mode squeezed states measured with balanced homodyne detection. Our work enables the implementation of arbitrary two-party quantum cryptographic protocols with continuous-variable communication systems.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-018-03729-4

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2553671-0

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Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System

Zeller, Tanja ; Seiffert, Moritz ; Müller, Christian ; [et al.]

Frontiers Media SA ; 2017

In: Frontiers in Cardiovascular Medicine Vol. 4 ( 2017-09-20)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 4 ( 2017-09-20)

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2017.00057

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2017

detail.hit.zdb_id: 2781496-8

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Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population

Blaum, Christopher ; Brunner, Fabian J ; Kröger, Friederike ; [et al.]

Oxford University Press (OUP) ; 2021

In: European Journal of Preventive Cardiology Vol. 28, No. 2 ( 2021-04-10), p. 152-158

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In: European Journal of Preventive Cardiology, Oxford University Press (OUP), Vol. 28, No. 2 ( 2021-04-10), p. 152-158

Abstract: Modifiable lifestyle risk factors (modRF) of coronary artery disease (CAD) are associated with increased inflammation represented by elevated C-reactive protein (CRP) levels. Lifestyle changes may influence the inflammatory burden in patients with CAD, relevantly modifying the target population for emerging anti-inflammatory compounds. Aims The aims of this study were to analyse the association of modRF and CRP levels in CAD patients, and to define a potential target population for anti-inflammatory treatment with and without the optimisation of modRF. Methods We included all patients with angiographically documented CAD from the observational cohort study INTERCATH. Patients with recent myocardial infarction, malignancy, infectious disease, and pre-existing immunosuppressive medication including a history of solid organ transplantation were excluded. Overweight (body mass index (BMI) ≥ 25 kg/m2), smoking, lack of physical activity (PA; & lt;1.5 h/week), and poor diet (≤12 points of an established Mediterranean diet score (MDS), range 0–28 points) were considered as modRF. CRP was measured by a high-sensitivity assay (hsCRP) at baseline. We performed multivariable linear regressions with log-transformed hsCRP as the dependent variable. Based on these associations, we calculated potential hsCRP levels for each patient, assuming optimisation of the individual modRF. Results Of 1014 patients, 737 (73%) were male, the mean age was 69 years, and 483 (48%) had an hsCRP ≥ 2 mg/l. ModRF were significantly overrepresented in patients with hsCRP ≥ 2 mg/l compared to patients with an hsCRP & lt; 2 mg/l (BMI ≥ 25 kg/m2: 76% vs 61%; PA & lt; 1.5 h/week: 69% vs 57%; MDS ≤ 12: 46% vs 37%; smoking: 61% vs 54%; p & lt; 0.05 for all). hsCRP increased with the incremental number of modRF present (median hsCRP values for N = 0, 1, 2, 3, and 4 modRF: 1.1, 1.0, 1.6, 2.4, 2.8 mg/l, p & lt; 0.001). Multivariable linear regression adjusting for age, sex, intake of lipid-lowering medication, and diabetes mellitus revealed independent associations between log-transformed hsCRP and all modRF (BMI ≥ 25 kg/m2: exp(ß) = 1.55, p & lt; 0.001; PA & lt; 1.5 h/week: exp(ß) = 1.33, p & lt; 0.001; MDS ≤ 12: exp(ß) = 1.18, p = 0.018; smoking: exp(ß) = 1.18, p = 0.019). Individual recalculation of hsCRP levels assuming optimisation of modRF identified 183 out of 483 (38%) patients with hsCRP ≥ 2 mg/l who could achieve an hsCRP & lt; 2 mg/l via lifestyle changes. Conclusion modRF are strongly and independently associated with CRP levels in patients with CAD. A relevant portion of CAD patients with high inflammatory burden could achieve an hsCRP & lt; 2 mg/l by lifestyle changes alone. This should be considered both in view of the cost and side-effects of pharmacological anti-inflammatory treatment and for the design of future clinical trials in this field.

Type of Medium: Online Resource

ISSN: 2047-4873 , 2047-4881

URL: Article

DOI: 10.1177/2047487319885458

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2646239-4

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Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the first and the consecutive upsurges of the second wave of the COVID-19 pandemic in the Netherlands

Dongelmans, Dave A. ; Termorshuizen, Fabian ; Brinkman, Sylvia ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Annals of Intensive Care Vol. 12, No. 1 ( 2022-12)

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In: Annals of Intensive Care, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-12)

Abstract: To assess trends in the quality of care for COVID-19 patients at the ICU over the course of time in the Netherlands. Methods Data from the National Intensive Care Evaluation (NICE)-registry of all COVID-19 patients admitted to an ICU in the Netherlands were used. Patient characteristics and indicators of quality of care during the first two upsurges (N = 4215: October 5, 2020–January 31, 2021) and the final upsurge of the second wave, called the ‘third wave’ (N = 4602: February 1, 2021–June 30, 2021) were compared with those during the first wave (N = 2733, February–May 24, 2020). Results During the second and third wave, there were less patients treated with mechanical ventilation (58.1 and 58.2%) and vasoactive drugs (48.0 and 44.7%) compared to the first wave (79.1% and 67.2%, respectively). The occupancy rates as fraction of occupancy in 2019 (1.68 and 1.55 vs. 1.83), the numbers of ICU relocations (23.8 and 27.6 vs. 32.3%) and the mean length of stay at the ICU (HRs of ICU discharge = 1.26 and 1.42) were lower during the second and third wave. No difference in adjusted hospital mortality between the second wave and the first wave was found, whereas the mortality during the third wave was considerably lower (OR = 0.80, 95% CI [0.71–0.90] ). Conclusions These data show favorable shifts in the treatment of COVID-19 patients at the ICU over time. The adjusted mortality decreased in the third wave. The high ICU occupancy rate early in the pandemic does probably not explain the high mortality associated with COVID-19.

Type of Medium: Online Resource

ISSN: 2110-5820

URL: Article

DOI: 10.1186/s13613-021-00978-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2617094-2

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Effects of glyphosate residues and different concentrate feed proportions in dairy cow rations on hepatic gene expression, liver histology and biochemical blood parameters

Heymann, Ann-Katrin ; Schnabel, Karina ; Billenkamp, Fabian ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 2 ( 2021-2-12), p. e0246679-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-12), p. e0246679-

Abstract: Glyphosate (GLY) is worldwide one of the most used active substances in non-selective herbicides. Although livestock might be orally exposed via GLY-contaminated feedstuffs, not much is known about possible hepatotoxic effects of GLY. As hepatic xenobiotic and nutrient metabolism are interlinked, toxic effects of GLY residues might be influenced by hepatic nutrient supply. Therefore, a feeding trial with lactating dairy cows was conducted to investigate effects of GLY-contaminated feedstuffs and different concentrate feed proportions (CFP) in the diets as tool for varying nutrient supply to the liver. For this, 61 German Holstein cows (207 ± 49 days in milk; mean ± standard deviation) were either fed a GLY-contaminated total mixed ration (TMR, GLY groups, mean GLY intake 122.7 μg/kg body weight/day) or control TMR (CON groups, mean GLY intake 1.2 μg/kg body weight/day) for 16 weeks. Additionally, both groups were further split into subgroups fed a lower (LC, 30% on dry matter basis) or higher (HC, 60% on dry matter basis) CFP resulting in groups CON HC (n = 16), CON LC (n = 16), GLY HC (n = 15), GLY LC (n = 14). Blood parameters aspartate aminotransferase, γ-glutamyltransferase, glutamate dehydrogenase, cholesterol, triglyceride, total protein, calcium, phosphorus, acetic acid and urea and histopathological evaluation were not influenced by GLY, whereas all mentioned parameters were at least affected by time, CFP or an interactive manner between time and CFP. Total bilirubin blood concentration was significantly influenced by an interaction between GLY and CFP with temporarily elevated concentrations in GLY HC , whereas the biological relevance remained unclear. Gene expression analysis indicated 167 CFP-responsive genes, while seven genes showed altered expression in GLY groups compared to CON groups. Since expression changes of GLY-responsive genes were low and liver-related blood parameters changed either not at all or only slightly, the tested GLY formulation was considered to have no toxic effects on the liver of dairy cows.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0246679

DOI: 10.1371/journal.pone.0246679.g001

DOI: 10.1371/journal.pone.0246679.g002

DOI: 10.1371/journal.pone.0246679.g003

DOI: 10.1371/journal.pone.0246679.g004

DOI: 10.1371/journal.pone.0246679.t001

DOI: 10.1371/journal.pone.0246679.t002

DOI: 10.1371/journal.pone.0246679.t003

DOI: 10.1371/journal.pone.0246679.s001

DOI: 10.1371/journal.pone.0246679.s002

DOI: 10.1371/journal.pone.0246679.s003

DOI: 10.1371/journal.pone.0246679.s004

DOI: 10.1371/journal.pone.0246679.s005

DOI: 10.1371/journal.pone.0246679.s006

DOI: 10.1371/journal.pone.0246679.s007

DOI: 10.1371/journal.pone.0246679.s008

DOI: 10.1371/journal.pone.0246679.s009

DOI: 10.1371/journal.pone.0246679.s010

DOI: 10.1371/journal.pone.0246679.s011

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

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