In:
Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 56, No. 3 ( 1994-09-01), p. 218-224
Abstract:
The importance of macrophage-tropic HIV-1 variants in AIDS pathogenesis becomes increasingly clear. Macrophage-tropic HIV-1 variants initiate infection, predominate in the asymptomatic phase, and persist throughout infection, even after the emergence of preferential T cell-tropic HIV-1 variants. HIV-1 infection of macrophages may contribute to the overall immune dysfunction observed in AIDS pathogenesis. Here, our knowledge of the biological variability of HIV-1, and specifically macrophage-tropic HIV-1 variants, is reviewed. Moreover, hypotheses about the mechanism of selection for macrophage-tropic variants in transmission, the mechanism by which these variants selectively persist in the asymptomatic phase, and how they may contribute to the general immune dysfunction are presented. J. Leukoc. Biol. 56: 218–224; 1994.
Type of Medium:
Online Resource
ISSN:
0741-5400
,
1938-3673
DOI:
10.1002/jlb.56.3.218
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1994
detail.hit.zdb_id:
2026833-6
SSG:
12
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