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Protection of mice against SV40 tumours by Pam3Cys, MTP-PE and Pam3Cys conjugated with the SV40 T antigen-derived peptide, K(698)-T(708)

Obert, Matthias ; Pleuger, Hendrik ; Hanagarth, Hans-Günter ; [et al.]

Elsevier BV ; 1998

In: Vaccine Vol. 16, No. 2-3 ( 1998-1), p. 161-169

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In: Vaccine, Elsevier BV, Vol. 16, No. 2-3 ( 1998-1), p. 161-169

Type of Medium: Online Resource

ISSN: 0264-410X

URL: Article

DOI: 10.1016/S0264-410X(97)00181-3

Language: English

Publisher: Elsevier BV

Publication Date: 1998

detail.hit.zdb_id: 1468474-3

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Nano-sized Crystals of Silicon Embedded in Silica Glass: Large Scale Models and Aspects of the Electronic Structure

Kroll, Peter ; Schulte, Hendrik J.

Springer Science and Business Media LLC ; 2006

In: MRS Proceedings Vol. 958 ( 2006)

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In: MRS Proceedings, Springer Science and Business Media LLC, Vol. 958 ( 2006)

Abstract: We construct quasi-spherical Si nanocrystallites consisting of 17, 29, 47, 71, and 99 atoms with diameters from 0.8 to 1.6 nm embedded in an SiO 2 network. All atoms have saturated bonds: Si is four-fold connected and O is two-fold connected. The models comprise 400-600 atoms and have lattice parameters of about 2 nm. The networks are subjected to a bond switching algorithm yielding models of nanocrystalline Si embedded in amorphous silica. Subsequently, we employ density functional methods. As a result of the DFT-optimization we find that the Si nanocrystals are free of defects at the interface to the host matrix. Si-Si distances within the Si nanocrystallites are strained, the strain itself tailors off to the suboxide interface. The excess energy of the optimized models with respect to crystalline silicon and vitreous silica scales linearly with the surface of the Si nanoparticles. The interfacial energy of the nc-Si/SiO 2 interface is calculated to 1.5 J/m 2 . We observe an increase of the band gap with decreasing cluster size due to the quantum-confinement effect. The highest occupied states of the valence band are located at Si-Si bonds close to the interface; the corresponding charge density forms a shell-like structure around the central core of the nanocrystal. The lowest unoccupied states are centered within the nanocrystal.

Type of Medium: Online Resource

ISSN: 0272-9172 , 1946-4274

URL: Article

DOI: 10.1557/PROC-0958-L07-16

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2006

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Schulte, Bianca ; Marx, Benjamin ; Korencak, Marek ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Medicine Vol. 8 ( 2021-7-23)

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In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-7-23)

Abstract: We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to high levels in the upper respiratory tract over the course of several days in the presence of strong antibody responses. The virus was readily propagatable in vitro , demonstrating the potential to transmit to others, bolstered by the fact that several household members were equally infected. This highlights the importance of protective measures even in vaccinated individuals.

Type of Medium: Online Resource

ISSN: 2296-858X

URL: Article

DOI: 10.3389/fmed.2021.704719

DOI: 10.3389/fmed.2021.704719.s001

DOI: 10.3389/fmed.2021.704719.s002

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2775999-4

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Author Correction: The landscape of genomic alterations across childhood cancers

Gröbner, Susanne N. ; ICGC PedBrain-Seq Project ; Worst, Barbara C. ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Nature Vol. 559, No. 7714 ( 2018-7), p. E10-E10

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In: Nature, Springer Science and Business Media LLC, Vol. 559, No. 7714 ( 2018-7), p. E10-E10

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-018-0167-2

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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Smoking is Associated with Reduced Frequency of SARS-CoV-2 Infection

Schulte, Bianca ; Wessendorf, Lukas ; Lehmann, Nils ; [et al.]

Elsevier BV ; 2021

In: SSRN Electronic Journal

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In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.3786061

Language: English

Publisher: Elsevier BV

Publication Date: 2021

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High-Efficiency Modules With Passivated Emitter and Rear Solar Cells—An Analysis of Electrical and Optical Losses

Schulte-Huxel, Henning ; Witteck, Robert ; Holst, Hendrik ; [et al.]

Institute of Electrical and Electronics Engineers (IEEE) ; 2017

In: IEEE Journal of Photovoltaics Vol. 7, No. 1 ( 2017-1), p. 25-31

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In: IEEE Journal of Photovoltaics, Institute of Electrical and Electronics Engineers (IEEE), Vol. 7, No. 1 ( 2017-1), p. 25-31

Type of Medium: Online Resource

ISSN: 2156-3381 , 2156-3403

URL: Article

DOI: 10.1109/JPHOTOV.2016.2614121

Language: Unknown

Publisher: Institute of Electrical and Electronics Engineers (IEEE)

Publication Date: 2017

detail.hit.zdb_id: 2585714-9

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Principle of Module-Level Processing Demonstrated at Single a-Si:H/c-Si Heterojunction Solar Cells

Petermann, Jan Hendrik ; Schulte-Huxel, Henning ; Steckenreiter, Verena ; [et al.]

Institute of Electrical and Electronics Engineers (IEEE) ; 2014

In: IEEE Journal of Photovoltaics Vol. 4, No. 4 ( 2014-7), p. 1018-1024

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In: IEEE Journal of Photovoltaics, Institute of Electrical and Electronics Engineers (IEEE), Vol. 4, No. 4 ( 2014-7), p. 1018-1024

Type of Medium: Online Resource

ISSN: 2156-3381 , 2156-3403

URL: Article

DOI: 10.1109/JPHOTOV.2014.2314576

Language: Unknown

Publisher: Institute of Electrical and Electronics Engineers (IEEE)

Publication Date: 2014

detail.hit.zdb_id: 2585714-9

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Porin Involvement in Cephalosporin and Carbapenem Resistance of Burkholderia pseudomallei

Aunkham, Anuwat ; Schulte, Albert ; Winterhalter, Mathias ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 5 ( 2014-5-1), p. e95918-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 5 ( 2014-5-1), p. e95918-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0095918

DOI: 10.1371/journal.pone.0095918.g001

DOI: 10.1371/journal.pone.0095918.g002

DOI: 10.1371/journal.pone.0095918.g003

DOI: 10.1371/journal.pone.0095918.g004

DOI: 10.1371/journal.pone.0095918.g005

DOI: 10.1371/journal.pone.0095918.g006

DOI: 10.1371/journal.pone.0095918.g007

DOI: 10.1371/journal.pone.0095918.t001

DOI: 10.1371/journal.pone.0095918.t002

DOI: 10.1371/journal.pone.0095918.t003

DOI: 10.1371/journal.pone.0095918.s001

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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CO 2 hydrogenation to hydrocarbons over iron nanoparticles supported on oxygen-functionalized carbon nanotubes

CHEW, LY MAY ; RULAND, HOLGER ; SCHULTE, HENDRIK J ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Journal of Chemical Sciences Vol. 126, No. 2 ( 2014-3), p. 481-486

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In: Journal of Chemical Sciences, Springer Science and Business Media LLC, Vol. 126, No. 2 ( 2014-3), p. 481-486

Type of Medium: Online Resource

ISSN: 0974-3626 , 0973-7103

URL: Article

DOI: 10.1007/s12039-014-0591-2

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2064209-X

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Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

Heide, Janna ; Schulte, Sophia ; Kohsar, Matin ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Pathogens Vol. 17, No. 9 ( 2021-9-16), p. e1009842-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2021-9-16), p. e1009842-

Abstract: The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set of 135 overlapping 15-mer peptides covering the SARS-CoV-2 envelope (E), membrane (M) and nucleoprotein (N) in a cohort of 34 individuals with acute (n = 10) and resolved (n = 24) COVID-19. Following short-term virus-specific in vitro cultivation, the single peptide-specific CD4+ T cell response of each patient was screened using enzyme linked immuno spot assay (ELISpot) and confirmed by single-peptide intracellular cytokine staining (ICS) for interferon-γ (IFN-γ) production. 97% (n = 33) of patients elicited one or more N, M or E-specific CD4+ T cell responses and each patient targeted on average 21.7 (range 0–79) peptide specificities. Overall, we identified 10 N, M or E-specific peptides that showed a response frequency of more than 36% and five of them showed high binding affinity to multiple HLA class II binders in subsequent in vitro HLA binding assays. Three peptides elicited CD4+ T cell responses in more than 55% of all patients, namely Mem_P30 (aa146-160), Mem_P36 (aa176-190), both located within the M protein, and Ncl_P18 (aa86-100) located within the N protein. These peptides were further defined in terms of length and HLA restriction. Based on this epitope and restriction data we developed a novel DRB*11 tetramer (Mem_aa145-164) and examined the ex vivo phenotype of SARS-CoV-2-specific CD4+ T cells in one patient. This detailed characterization of single T cell peptide responses demonstrates that SARS-CoV-2 infection universally primes a broad T cell response directed against multiple specificities located within the N, M and E structural protein.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1009842

DOI: 10.1371/journal.ppat.1009842.g001

DOI: 10.1371/journal.ppat.1009842.g002

DOI: 10.1371/journal.ppat.1009842.g003

DOI: 10.1371/journal.ppat.1009842.g004

DOI: 10.1371/journal.ppat.1009842.g005

DOI: 10.1371/journal.ppat.1009842.g006

DOI: 10.1371/journal.ppat.1009842.t001

DOI: 10.1371/journal.ppat.1009842.t002

DOI: 10.1371/journal.ppat.1009842.t003

DOI: 10.1371/journal.ppat.1009842.t004

DOI: 10.1371/journal.ppat.1009842.t005

DOI: 10.1371/journal.ppat.1009842.t006

DOI: 10.1371/journal.ppat.1009842.t007

DOI: 10.1371/journal.ppat.1009842.s001

DOI: 10.1371/journal.ppat.1009842.s002

DOI: 10.1371/journal.ppat.1009842.s003

DOI: 10.1371/journal.ppat.1009842.s004

DOI: 10.1371/journal.ppat.1009842.s005

DOI: 10.1371/journal.ppat.1009842.s006

DOI: 10.1371/journal.ppat.1009842.s007

DOI: 10.1371/journal.ppat.1009842.s008

DOI: 10.1371/journal.ppat.1009842.s009

DOI: 10.1371/journal.ppat.1009842.s010

DOI: 10.1371/journal.ppat.1009842.s011

DOI: 10.1371/journal.ppat.1009842.s012

DOI: 10.1371/journal.ppat.1009842.s013

DOI: 10.1371/journal.ppat.1009842.s014

DOI: 10.1371/journal.ppat.1009842.s015

DOI: 10.1371/journal.ppat.1009842.s016

DOI: 10.1371/journal.ppat.1009842.r001

DOI: 10.1371/journal.ppat.1009842.r002

DOI: 10.1371/journal.ppat.1009842.r003

DOI: 10.1371/journal.ppat.1009842.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2205412-1

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