In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-11-22)
Abstract:
11 C-acetate is a positron emission tomography (PET) tracer of oxidative metabolism, whereas hyperpolarized 13 C-acetate can be used in magnetic resonance imaging (MRI) for investigating specific metabolic processes. The aims of this study were to examine if the kinetic formalism of 11 C-acetate PET in the kidneys is comparable to that of 13 C-acetate MRI, and to compare the dynamic metabolic information of hyperpolarized 13 C-acetate MRI with that obtained with 11 C-acetate PET. Rats were examined with dynamic hyperpolarized 13 C-acetate MRI or 11 C-acetate PET before and after intravenous injection of furosemide, a loop diuretic known to alter both the hemodynamics and oxygen consumption in the kidney. The metabolic clearance rates (MCR) were estimated and compared between the two modalities experimentally in vivo and in simulations. There was a clear dependency on the mean transit time and MCR for both 13 C-acetate and 11 C-acetate following furosemide administration, while no dependencies on the apparent renal perfusion were observed. This study demonstrated that hyperpolarized 13 C-acetate MRI is feasible for measurements of the intrarenal energetic demand via the MCR, and that the quantitative measures are correlated with those measured by 11 C-acetate PET, even though the temporal window is more than 30 times longer with 11 C-acetate.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-017-15929-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
2615211-3
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