In:
Angewandte Chemie, Wiley, Vol. 127, No. 13 ( 2015-03-23), p. 4039-4044
Abstract:
The blood–brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain. In fact, less than 2 % of all potential neurotherapeutics are able to cross it. Here, by applying the retro‐enantio approach to a peptide that targets the transferrin receptor, a full protease‐resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v127.13
DOI:
10.1002/ange.201411408
Language:
German
Publisher:
Wiley
Publication Date:
2015
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505872-7
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1479266-7
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