In:
The EMBO Journal, EMBO, Vol. 36, No. 9 ( 2017-05-02), p. 1199-1214
Abstract:
image ER α binds the mi RNA ‐22 precursor and prevents its processing, while mature miR‐22 represses ER α translation. This feedback loop leads to sex‐specific levels of ER α in muscle with consequences for muscular lipid metabolism and body weight. ER α directly binds to a specific motif in the primary miR‐22 precursor. ER α limits the formation of mature miR‐22 in female muscle and allows higher concentration of miR‐22 in male muscle. Mature miR‐22 represses ER α protein translation in male muscle. The miR‐22– ER α feedback loop restricts lipid metabolism in male muscle and allows gain of white fat depots in male mice.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201695988
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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