In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2020-12-28), p. e1009190-
Abstract:
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A total of 200 genes were found to significantly affect BMD. This pool of BMD genes comprised 141 genes with previously unknown functions in bone biology and was complementary to pools derived from recent human studies. Nineteen of the 141 genes also caused skeletal abnormalities. Examination of the BMD genes in osteoclasts and osteoblasts underscored BMD pathways, including vesicle transport, in these cells and together with in silico bone turnover studies resulted in the prioritization of candidate genes for further investigation. Overall, the results add novel pathophysiological and molecular insight into bone health and disease.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009190
DOI:
10.1371/journal.pgen.1009190.g001
DOI:
10.1371/journal.pgen.1009190.g002
DOI:
10.1371/journal.pgen.1009190.g003
DOI:
10.1371/journal.pgen.1009190.g004
DOI:
10.1371/journal.pgen.1009190.g005
DOI:
10.1371/journal.pgen.1009190.g006
DOI:
10.1371/journal.pgen.1009190.t001
DOI:
10.1371/journal.pgen.1009190.t002
DOI:
10.1371/journal.pgen.1009190.s001
DOI:
10.1371/journal.pgen.1009190.s002
DOI:
10.1371/journal.pgen.1009190.s003
DOI:
10.1371/journal.pgen.1009190.s004
DOI:
10.1371/journal.pgen.1009190.s005
DOI:
10.1371/journal.pgen.1009190.s006
DOI:
10.1371/journal.pgen.1009190.s007
DOI:
10.1371/journal.pgen.1009190.s008
DOI:
10.1371/journal.pgen.1009190.s009
DOI:
10.1371/journal.pgen.1009190.s010
DOI:
10.1371/journal.pgen.1009190.s011
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2186725-2
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