KOBV Portal

Hits per page

hits 1 - 10 | 10 hits

Sorting

Online Resource

Treatment with etanercept and low monocyte concentration contribute to the risk of invasive aspergillosis in patients post allogeneic stem cell transplantation

Zoran, Tamara ; Weber, Michael ; Springer, Jan ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Scientific Reports Vol. 9, No. 1 ( 2019-11-21)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-11-21)

Abstract: Invasive aspergillosis (IA) is a life-threatening complication among allogeneic hematopoietic stem cell transplant (alloSCT) recipients. Despite well known risk factors and different available assays, diagnosis of invasive aspergillosis remains challenging. 103 clinical variables from patients with hematological malignancies and subsequent alloSCT were collected. Associations between collected variables and patients with (n = 36) and without IA (n = 36) were investigated by applying univariate and multivariable logistic regression. The predictive power of the final model was tested in an independent patient cohort (23 IA cases and 25 control patients). Findings were investigated further by in vitro studies, which analysed the effect of etanercept on A. fumigatus -stimulated macrophages at the gene expression and cytokine secretion. Additionally, the release of C-X-C motif chemokine ligand 10 (CXCL10) in patient sera was studied. Low monocyte concentration (p = 4.8 × 10 −06 ), severe GvHD of the gut (grade 2–4) (p = 1.08 × 10 −02 ) and etanercept treatment of GvHD (p = 3.5 × 10 −03 ) were significantly associated with IA. Our studies showed that etanercept lowers CXCL10 concentrations in vitro and ex vivo and down-regulates genes involved in immune responses and TNF-alpha signaling. Our study offers clinicians new information regarding risk factors for IA including low monocyte counts and administration of etanercept. After necessary validation, such information may be used for decision making regarding antifungal prophylaxis or closely monitoring patients at risk.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-019-53504-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Risk Assessment with Gene Expression Markers in Sepsis Development

Garcia Lopez, Albert ; Schäuble, Sascha ; Sae-Ong, Tongta ; [et al.]

Elsevier BV ; 2022

In: SSRN Electronic Journal

add to watchlist on the watchlist

Details

In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.4261556

Language: English

Publisher: Elsevier BV

Publication Date: 2022

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients

Marfil-Sánchez, Andrea ; Seelbinder, Bastian ; Ni, Yueqiong ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 11 ( 2021-11-18), p. e0259898-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2021-11-18), p. e0259898-

Abstract: Impaired exercise tolerance and lung function is a marker for increased mortality in lung cancer patients undergoing lung resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic and immune functions, and microbiota might alter exercise tolerance. Here, we aimed to evaluate the associations between gut microbiota and outcomes in lung cancer patients who underwent lung resection surgery. We analysed stool samples, from 15 early-stage lung cancer patients, collected before and after surgical resection using shotgun metagenomic and Internal Transcribed Spacer (ITS) sequencing. We analysed microbiome and mycobiome associations with post-surgery lung function and cardiopulmonary exercise testing (CPET) to assess the maximum level of work achieved. There was a significant difference, between pre- and post-surgical resection samples, in microbial community functional profiles and several species from Alistipes and Bacteroides genus, associated with the production of SCFAs, increased significantly in abundance. Interestingly, an increase in VO 2 coincides with an increase in certain species and the "GABA shunt" pathway, suggesting that treatment outcome might improve by enriching butyrate-producing species. Here, we revealed associations between specific gut bacteria, fungi, and their metabolic pathways with the recovery of lung function and exercise capacity.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0259898

DOI: 10.1371/journal.pone.0259898.g001

DOI: 10.1371/journal.pone.0259898.g002

DOI: 10.1371/journal.pone.0259898.g003

DOI: 10.1371/journal.pone.0259898.g004

DOI: 10.1371/journal.pone.0259898.s001

DOI: 10.1371/journal.pone.0259898.s002

DOI: 10.1371/journal.pone.0259898.s003

DOI: 10.1371/journal.pone.0259898.s004

DOI: 10.1371/journal.pone.0259898.s005

DOI: 10.1371/journal.pone.0259898.s006

DOI: 10.1371/journal.pone.0259898.s007

DOI: 10.1371/journal.pone.0259898.s008

DOI: 10.1371/journal.pone.0259898.s009

DOI: 10.1371/journal.pone.0259898.s010

DOI: 10.1371/journal.pone.0259898.s011

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Antibiotics make way for fungal invasion in human gut

Seelbinder, Bastian ; Chen, Jiarui ; Brunke, Sascha ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Microbiome Vol. 8, No. 1 ( 2020-12)

add to watchlist on the watchlist

Details

In: Microbiome, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2020-12)

Abstract: Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs targeting bacteria are therefore seen as an important risk factor for fungal infections and induced allergies. However, antibiotic effects on gut bacterial-fungal interactions, including disruption and resilience of fungal community compositions, were not investigated in humans. We analysed stool samples collected from 14 healthy human participants over 3 months following a 6-day antibiotic administration. We integrated data from shotgun metagenomics, metatranscriptomics, metabolomics, and fungal ITS2 sequencing. Results While the bacterial community recovered mostly over 3 months post treatment, the fungal community was shifted from mutualism at baseline to competition. Half of the bacterial-fungal interactions present before drug intervention had disappeared 3 months later. During treatment, fungal abundances were associated with the expression of bacterial genes with functions for cell growth and repair. By extending the metagenomic species approach, we revealed bacterial strains inhibiting the opportunistic fungal pathogen Candida albicans . We demonstrated in vitro how C . albicans pathogenicity and host cell damage might be controlled naturally in the human gut by bacterial metabolites such as propionate or 5-dodecenoate. Conclusions We demonstrated that antibacterial drugs have long-term influence on the human gut mycobiome. While bacterial communities recovered mostly 30-days post antibacterial treatment, the fungal community was shifted from mutualism towards competition.

Type of Medium: Online Resource

ISSN: 2049-2618

URL: Article

DOI: 10.1186/s40168-020-00899-6

DOI: 10.21203/rs.3.rs-106691/v1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2697425-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Co-culturing Bacillus subtilis and wastewater microbial community in a bio-electrochemical system enhances denitrification and butyrate formation

Rahimi, Shadi ; Modin, Oskar ; Roshanzamir, Fariba ; [et al.]

Elsevier BV ; 2020

In: Chemical Engineering Journal Vol. 397 ( 2020-10), p. 125437-

add to watchlist on the watchlist

Details

In: Chemical Engineering Journal, Elsevier BV, Vol. 397 ( 2020-10), p. 125437-

Type of Medium: Online Resource

ISSN: 1385-8947

URL: Article

DOI: 10.1016/j.cej.2020.125437

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 241367-X

detail.hit.zdb_id: 2012137-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection

Barber, Amelia E. ; Sae-Ong, Tongta ; Kang, Kang ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Nature Microbiology Vol. 6, No. 12 ( 2021-11-24), p. 1526-1536

add to watchlist on the watchlist

Details

In: Nature Microbiology, Springer Science and Business Media LLC, Vol. 6, No. 12 ( 2021-11-24), p. 1526-1536

Type of Medium: Online Resource

ISSN: 2058-5276

URL: Article

DOI: 10.1038/s41564-021-00993-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2845610-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Molecular Profiling Reveals Characteristic and Decisive Signatures in Patients after Allogeneic Stem Cell Transplantation Suffering from Invasive Pulmonary Aspergillosis

Zoran, Tamara ; Seelbinder, Bastian ; White, Philip ; [et al.]

MDPI AG ; 2022

In: Journal of Fungi Vol. 8, No. 2 ( 2022-02-10), p. 171-

add to watchlist on the watchlist

Details

In: Journal of Fungi, MDPI AG, Vol. 8, No. 2 ( 2022-02-10), p. 171-

Abstract: Despite available diagnostic tests and recent advances, diagnosis of pulmonary invasive aspergillosis (IPA) remains challenging. We performed a longitudinal case-control pilot study to identify host-specific, novel, and immune-relevant molecular candidates indicating IPA in patients post allogeneic stem cell transplantation (alloSCT). Supported by differential gene expression analysis of six relevant in vitro studies, we conducted RNA sequencing of three alloSCT patients categorized as probable IPA cases and their matched controls without Aspergillus infection (66 samples in total). We additionally performed immunoassay analysis for all patient samples to gain a multi-omics perspective. Profiling analysis suggested LGALS2, MMP1, IL-8, and caspase-3 as potential host molecular candidates indicating IPA in investigated alloSCT patients. MMP1, IL-8, and caspase-3 were evaluated further in alloSCT patients for their potential to differentiate possible IPA cases and patients suffering from COVID-19-associated pulmonary aspergillosis (CAPA) and appropriate control patients. Possible IPA cases showed differences in IL-8 and caspase-3 serum levels compared with matched controls. Furthermore, we observed significant differences in IL-8 and caspase-3 levels among CAPA patients compared with control patients. With our conceptual work, we demonstrate the potential value of considering the human immune response during Aspergillus infection to identify immune-relevant molecular candidates indicating IPA in alloSCT patients. These human host candidates together with already established fungal biomarkers might improve the accuracy of IPA diagnostic tools.

Type of Medium: Online Resource

ISSN: 2309-608X

URL: Article

DOI: 10.3390/jof8020171

Language: English

Publisher: MDPI AG

Publication Date: 2022

detail.hit.zdb_id: 2784229-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions

Seelbinder, Bastian ; Lohinai, Zoltan ; Vazquez-Uribe, Ruben ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Communications Vol. 14, No. 1 ( 2023-05-09)

add to watchlist on the watchlist

Details

In: Nature Communications, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2023-05-09)

Abstract: Candida species overgrowth in the human gut is considered a prerequisite for invasive candidiasis, but our understanding of gut bacteria promoting or restricting this overgrowth is still limited. By integrating cross-sectional mycobiome and shotgun metagenomics data from the stool of 75 male and female cancer patients at risk but without systemic candidiasis, bacterial communities in high Candida samples display higher metabolic flexibility yet lower contributional diversity than those in low Candida samples. We develop machine learning models that use only bacterial taxa or functional relative abundances to predict the levels of Candida genus and species in an external validation cohort with an AUC of 78.6–81.1%. We propose a mechanism for intestinal Candida overgrowth based on an increase in lactate-producing bacteria, which coincides with a decrease in bacteria that regulate short chain fatty acid and oxygen levels. Under these conditions, the ability of Candida to harness lactate as a nutrient source may enable Candida to outcompete other fungi in the gut.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-023-38058-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2553671-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness

Marfil-Sánchez, Andrea ; Zhang, Lu ; Alonso-Pernas, Pol ; [et al.]

Informa UK Limited ; 2021

In: Gut Microbes Vol. 13, No. 1 ( 2021-01-01)

add to watchlist on the watchlist

Details

In: Gut Microbes, Informa UK Limited, Vol. 13, No. 1 ( 2021-01-01)

Type of Medium: Online Resource

ISSN: 1949-0976 , 1949-0984

URL: Article

DOI: 10.1080/19490976.2021.1993598

Language: English

Publisher: Informa UK Limited

Publication Date: 2021

detail.hit.zdb_id: 2575755-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model

Seelbinder, Bastian ; Wallstabe, Julia ; Marischen, Lothar ; [et al.]

Elsevier BV ; 2020

In: Cell Reports Vol. 33, No. 7 ( 2020-11), p. 108389-

add to watchlist on the watchlist

Details

In: Cell Reports, Elsevier BV, Vol. 33, No. 7 ( 2020-11), p. 108389-

Type of Medium: Online Resource

ISSN: 2211-1247

URL: Article

DOI: 10.1016/j.celrep.2020.108389

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2649101-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 10 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg