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1

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Zhijun ; Sevrioukova, Irina F. ; Denisov, Ilia G. ; [et al.]

Elsevier BV ; 2017

In: Cell Chemical Biology Vol. 24, No. 10 ( 2017-10), p. 1259-1275.e6

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In: Cell Chemical Biology, Elsevier BV, Vol. 24, No. 10 ( 2017-10), p. 1259-1275.e6

Type of Medium: Online Resource

ISSN: 2451-9456

URL: Article

DOI: 10.1016/j.chembiol.2017.08.009

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2850144-5

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2

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Zhijun ; Sevrioukova, Irina F. ; Denisov, Ilia G. ; [et al.]

Elsevier BV ; 2017

In: Cell Chemical Biology Vol. 24, No. 10 ( 2017-10), p. 1314-

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In: Cell Chemical Biology, Elsevier BV, Vol. 24, No. 10 ( 2017-10), p. 1314-

Type of Medium: Online Resource

ISSN: 2451-9456

URL: Article

DOI: 10.1016/j.chembiol.2017.09.012

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2850144-5

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3

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Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment

Samuels, Eric R. ; Sevrioukova, Irina F.

MDPI AG ; 2022

In: International Journal of Molecular Sciences Vol. 23, No. 13 ( 2022-06-30), p. 7291-

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In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 13 ( 2022-06-30), p. 7291-

Abstract: Controlled inhibition of drug-metabolizing cytochrome P450 3A4 (CYP3A4) is utilized to boost bioavailability of anti-viral and immunosuppressant pharmaceuticals. We investigate structure–activity relationships (SARs) in analogues of ritonavir, a potent CYP3A4 inhibitor marketed as pharmacoenhancer, to determine structural elements required for potent inhibition and whether the inhibitory potency can be further improved via a rational structure-based design. This study investigated eight (series VI) inhibitors differing in head- and end-moieties and their respective linkers. SAR analysis revealed the multifactorial regulation of inhibitory strength, with steric constraints imposed on the tethered heme-ligating moiety being a key factor. Minimization of these constraints by changing the linkers’ length/flexibility and N-heteroatom position strengthened heme coordination and markedly improved binding and/or inhibitory strength. Impact of the end-pyridine attachment was not uniform due to influence of other determinants controlling the ligand-binding mode. This interplay between pharmacophoric determinants and the end-group enlargement can be used for further inhibitor optimization.

Type of Medium: Online Resource

ISSN: 1422-0067

URL: Article

DOI: 10.3390/ijms23137291

Language: English

Publisher: MDPI AG

Publication Date: 2022

detail.hit.zdb_id: 2019364-6

SSG: 12

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4

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Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity

Chen, Yu-Jie ; Zhang, Jian ; Zhu, Ping-Ping ; [et al.]

American Society for Pharmacology & Experimental Therapeutics (ASPET) ; 2019

In: Drug Metabolism and Disposition Vol. 47, No. 6 ( 2019-06), p. 574-581

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In: Drug Metabolism and Disposition, American Society for Pharmacology & Experimental Therapeutics (ASPET), Vol. 47, No. 6 ( 2019-06), p. 574-581

Type of Medium: Online Resource

ISSN: 0090-9556 , 1521-009X

URL: Article

DOI: 10.1124/dmd.119.086637

Language: English

Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)

Publication Date: 2019

detail.hit.zdb_id: 1500213-5

SSG: 15,3

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5

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Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

Sevrioukova, Irina F.

Mary Ann Liebert Inc ; 2011

In: Antioxidants & Redox Signaling Vol. 14, No. 12 ( 2011-06-15), p. 2545-2579

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In: Antioxidants & Redox Signaling, Mary Ann Liebert Inc, Vol. 14, No. 12 ( 2011-06-15), p. 2545-2579

Type of Medium: Online Resource

ISSN: 1523-0864 , 1557-7716

URL: Article

DOI: 10.1089/ars.2010.3445

Language: English

Publisher: Mary Ann Liebert Inc

Publication Date: 2011

detail.hit.zdb_id: 2039747-1

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6

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Crystal Structure of Putidaredoxin Reductase from Pseudomonas putida, the Final Structural Component of the Cytochrome P450cam Monooxygenase

Sevrioukova, Irina F. ; Li, Huiying ; Poulos, Thomas L.

Elsevier BV ; 2004

In: Journal of Molecular Biology Vol. 336, No. 4 ( 2004-2), p. 889-902

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In: Journal of Molecular Biology, Elsevier BV, Vol. 336, No. 4 ( 2004-2), p. 889-902

Type of Medium: Online Resource

ISSN: 0022-2836

URL: Article

DOI: 10.1016/j.jmb.2003.12.067

Language: English

Publisher: Elsevier BV

Publication Date: 2004

detail.hit.zdb_id: 1355192-9

SSG: 12

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7

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Key Role of the Adenylate Moiety and Integrity of the Adenylate-Binding Site for the NAD + /H Binding to Mitochondrial Apoptosis-Inducing Factor

Sorrentino, Luca ; Calogero, Alessandra Maria ; Pandini, Vittorio ; [et al.]

American Chemical Society (ACS) ; 2015

In: Biochemistry Vol. 54, No. 47 ( 2015-12-01), p. 6996-7009

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In: Biochemistry, American Chemical Society (ACS), Vol. 54, No. 47 ( 2015-12-01), p. 6996-7009

Type of Medium: Online Resource

ISSN: 0006-2960 , 1520-4995

URL: Article

DOI: 10.1021/acs.biochem.5b00898

RVK:

WA 15000

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2015

detail.hit.zdb_id: 1472258-6

SSG: 12

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8

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High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4

Sevrioukova, Irina F.

American Chemical Society (ACS) ; 2017

In: Biochemistry Vol. 56, No. 24 ( 2017-06-20), p. 3058-3067

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In: Biochemistry, American Chemical Society (ACS), Vol. 56, No. 24 ( 2017-06-20), p. 3058-3067

Type of Medium: Online Resource

ISSN: 0006-2960 , 1520-4995

URL: Article

DOI: 10.1021/acs.biochem.7b00334

DOI: 10.1021/acs.biochem.7b00334.s001

RVK:

WA 15000

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2017

detail.hit.zdb_id: 1472258-6

SSG: 12

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9

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Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4

Denison, Madeline ; Ahrens, Justin J. ; Dunbar, Marilyn N. ; [et al.]

American Chemical Society (ACS) ; 2023

In: Inorganic Chemistry Vol. 62, No. 7 ( 2023-02-20), p. 3305-3320

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In: Inorganic Chemistry, American Chemical Society (ACS), Vol. 62, No. 7 ( 2023-02-20), p. 3305-3320

Type of Medium: Online Resource

ISSN: 0020-1669 , 1520-510X

URL: Article

DOI: 10.1021/acs.inorgchem.3c00059

DOI: 10.1021/acs.inorgchem.3c00059.s001

RVK:

VA 4680

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2023

detail.hit.zdb_id: 7558-9

detail.hit.zdb_id: 1484438-2

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10

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Laser Flash Induced Electron Transfer in P450cam Monooxygenase: Putidaredoxin Reductase−Putidaredoxin Interaction

Sevrioukova, Irina F. ; Hazzard, James T. ; Tollin, Gordon ; [et al.]

American Chemical Society (ACS) ; 2001

In: Biochemistry Vol. 40, No. 35 ( 2001-09-01), p. 10592-10600

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In: Biochemistry, American Chemical Society (ACS), Vol. 40, No. 35 ( 2001-09-01), p. 10592-10600

Type of Medium: Online Resource

ISSN: 0006-2960 , 1520-4995

URL: Article

DOI: 10.1021/bi010874d

RVK:

WA 15000

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2001

detail.hit.zdb_id: 1472258-6

SSG: 12

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Kooperativer Bibliotheksverbund

Berlin Brandenburg