In:
Annual Review of Immunology, Annual Reviews, Vol. 36, No. 1 ( 2018-04-26), p. 127-156
Abstract:
T cells possess an array of functional capabilities important for host defense against pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR). The TCR has no intrinsic enzymatic activity, and thus signal transduction from the receptor relies on additional signaling molecules. One such molecule is the cytoplasmic tyrosine kinase ZAP-70, which associates with the TCR complex and is required for initiating the canonical biochemical signal pathways downstream of the TCR. In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of ZAP-70 catalytic activity–dependent and –independent signals in developing and mature T cells. Lastly, we discuss the disease states in mouse models and humans, which range from immunodeficiency to autoimmunity, that are caused by mutations in ZAP-70.
Type of Medium:
Online Resource
ISSN:
0732-0582
,
1545-3278
DOI:
10.1146/immunol.2018.36.issue-1
DOI:
10.1146/annurev-immunol-042617-053335
Language:
English
Publisher:
Annual Reviews
Publication Date:
2018
detail.hit.zdb_id:
1470451-1
SSG:
12
Bookmarklink