In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2022-9-22), p. e0274841-
Abstract:
T-helper 17 cell-mediated response and their effector IL-17 cytokine induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major cause of COVID-19 disease severity and death. Therefore, the study aimed to determine if IL-17 level in saliva mirrors its circulatory level and hence can be used as a non-invasive biomarker for disease severity. Methods Interleukin-17 (IL-17) level was evaluated by ELISA in saliva and blood of 201 adult COVID-19 patients with different levels of severity. The IL-17 saliva level was also associated with COVID-19 disease severity, and need for mechanical ventilation and/or death within 29 days after admission of severe COVID-19 patients. Results We found that IL-17 level in saliva of COVID-19 patients reflected its circulatory level. High IL-17 level in saliva was associated with COVID-19 severity (P 〈 0.001), need for mechanical ventilation (P = 0.002), and/or death by 29 days (P = 0.002), after adjusting for patients’ demographics, comorbidity, and COVID-19 serum severity markers such as D-Dimer, C-reactive protein, and ferritin. Conclusion We propose that saliva IL-17 level could be used as a biomarker to identify patients at risk of developing severe COVID-19.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0274841
DOI:
10.1371/journal.pone.0274841.g001
DOI:
10.1371/journal.pone.0274841.g002
DOI:
10.1371/journal.pone.0274841.t001
DOI:
10.1371/journal.pone.0274841.s001
DOI:
10.1371/journal.pone.0274841.s002
DOI:
10.1371/journal.pone.0274841.s003
DOI:
10.1371/journal.pone.0274841.s004
DOI:
10.1371/journal.pone.0274841.s005
DOI:
10.1371/journal.pone.0274841.r001
DOI:
10.1371/journal.pone.0274841.r002
DOI:
10.1371/journal.pone.0274841.r003
DOI:
10.1371/journal.pone.0274841.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Bookmarklink