In:
Circulation: Cardiovascular Imaging, Ovid Technologies (Wolters Kluwer Health), Vol. 6, No. 5 ( 2013-09), p. 637-645
Abstract:
Fabry disease (FD) is an X-linked disorder of lysosomal metabolism affecting multiple organs with cardiac disease being the leading cause of death. Current imaging evaluations of the heart are suboptimal. The goals of the current study are to evaluate the potential of quantitative T 1 mapping with cardiovascular MRI as a disease-specific imaging biomarker. Methods and Results— A total of 31 patients with FD, 23 healthy controls, and 21 subjects with concentric remodeling or hypertrophy underwent cardiovascular MRI to measure left ventricular (LV) morphology, function, delayed enhancement, as well as myocardial T 1 values, and derived parameters (extracellular volume). All subjects had LV ejection fraction 〉 50% and similar volumes. FD and concentric remodeling or hypertrophy had similarly increased mass, wall thickness, and mass/volume as compared with controls. A total of 16 of 31 FD subjects and 10 of 21 concentric remodeling or hypertrophy subjects had LV hypertrophy. Noncontrast myocardial T 1 values were substantially lower in FD as compared with controls and concentric remodeling or hypertrophy (1070±50, 1177±27, and 1207±33 ms, respectively; P 〈 0.001), but extracellular volume was similar in all groups (21.7±2.4%, 22.2±3.1%, and 21.8±3.9%, respectively). Single-voxel NMR spectroscopy in 4 FD and 4 healthy control subjects showed a significant negative linear relationship between lipid content and noncontrast T 1 values ( r =−0.9; P =0.002). Female subjects had lower LV mass and wall thickness, longer myocardial T 1 values and larger extracellular volume suggesting a key sex difference in cardiac remodeling. Conclusions— Reduced noncontrast myocardial T 1 values are the most sensitive and specific cardiovascular MRI parameter in patients with FD irrespective of sex and LV morphology and function.
Type of Medium:
Online Resource
ISSN:
1941-9651
,
1942-0080
DOI:
10.1161/CIRCIMAGING.113.000482
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2013
detail.hit.zdb_id:
2440475-5
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