In:
Current Protein & Peptide Science, Bentham Science Publishers Ltd., Vol. 20, No. 10 ( 2019-09-20), p. 1004-1011
Abstract:
Cardiovascular disease (CVD) is the biggest killer globally and atherosclerosis (AS) is the
major trigger to this pathology. Abnormal cholesterol homeostasis is the starting point of AS, especially the aggregation of macrophage foam cells in the intra-arterial subcutaneous region. Reverse cholesterol
transport (RCT) can remove excess cholesterol from macrophages and transport it to the liver for excretion, making this process vital to alleviate AS. MicroRNAs (miRNAs) are small, noncoding RNAs that
play critical roles in various diseases including AS, by regulating post-transcriptional gene expression. Many natural compounds can exert anti-atherosclerotic effects by regulating different miRNAs that are
implicated in RCT. Hence, targeting these miRNAs using natural functional compounds may be a safe, novel, and promising strategy to prevent and treat AS. This review describes the miRNAs involved in
RCT and the potential uses of natural compounds to target RCT-related miRNAs to modulate AS.
Type of Medium:
Online Resource
ISSN:
1389-2037
DOI:
10.2174/1389203720666190827143218
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2019
SSG:
12
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