In:
International Journal of Pharmacokinetics, Future Science Ltd, Vol. 1, No. 1 ( 2016-10), p. 17-23
Abstract:
Aim: The effect on pharmacokinetics and postcoital contraceptive efficacy of centchroman was investigated after concomitant administration of losartan. Materials & methods: An LC-MS/MS method was employed for quantification of centchroman in blood of female rats treated with centchroman (1.5 mg/kg) only and centchroman plus losartan (5 mg/kg, once daily up to day 7). The effect of losartan on the postcoital contraceptive activity of centchroman was evaluated in sperm-positive female rats. Results: The area under the curve and mean residence time values were decreased in losartan concomitant group, however, sperm-positive female rats did not exhibit any implantations in either centchroman only or losartan co-administered group of female rats. Conclusion: The study evidenced no pharmacological interaction of losartan with centchroman.
Type of Medium:
Online Resource
ISSN:
2053-0846
,
2053-0854
DOI:
10.4155/ipk-2015-0001
Language:
English
Publisher:
Future Science Ltd
Publication Date:
2016
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