In:
The EMBO Journal, EMBO, Vol. 42, No. 10 ( 2023-05-15)
Abstract:
image Estrogen receptor (ER)α, encoded by ESR1 , promotes mammary malignancies and is targeted in cancer therapy; however, resistance arises frequently. This study reports a novel circRNA, termed circPVT1, with dual mechanisms to enhance ER‐positive breast tumorigenesis, suggesting therapeutic opportunities. CircPVT1 is highly expressed in ERα‐positive breast tumor patients. CircPVT1 sponges miR‐181a‐2‐3p to stabilize ESR1 mRNA, activating the expression of estrogen/ERα‐target genes. CircPVT1 interacts with MAVS protein to disrupt RIGI–MAVS complex formation, repressing the expression of type I IFN and interferon‐stimulated genes. ASO‐targeting circPVT1 suppresses ERα‐positive breast cancer cell and tumor growth.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022112408
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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