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World Congress Integrative Medicine & Health 2017: Part one : Berlin, Germany. 3-5 May 2017

Brinkhaus, Benno ; Falkenberg, Torkel ; Haramati, Aviad ; [et al.]

Springer Science and Business Media LLC ; 2017

In: BMC Complementary and Alternative Medicine Vol. 17, No. S1 ( 2017-6)

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In: BMC Complementary and Alternative Medicine, Springer Science and Business Media LLC, Vol. 17, No. S1 ( 2017-6)

Type of Medium: Online Resource

ISSN: 1472-6882

URL: Article

DOI: 10.1186/s12906-017-1782-4

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2050429-9

detail.hit.zdb_id: 3037610-5

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The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder

Chen, Xiao ; Lu, Bin ; Li, Hui-Xian ; [et al.]

Oxford University Press (OUP) ; 2022

In: Psychoradiology Vol. 2, No. 1 ( 2022-06-09), p. 32-42

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In: Psychoradiology, Oxford University Press (OUP), Vol. 2, No. 1 ( 2022-06-09), p. 32-42

Abstract: Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, the Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with a standardized pipeline across all participating sites, has been the first effort from DIRECT. In this review, we present an overview of the motivations, rationale, and principal findings of the studies so far from the REST-meta-MDD project. Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization. These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research. Following these fruitful explorations, DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations. A state-of-the-art, surface-based preprocessing pipeline has also been introduced to improve sensitivity. Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diagnosis boundaries. In addition, large-scale longitudinal studies targeting brain network alterations following antidepressant treatment, aggregation of diffusion tensor images, and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway. Through these endeavours, we hope to accelerate the translation of functional neuroimaging findings to clinical use, such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets, while building an open repository for the scientific community.

Type of Medium: Online Resource

ISSN: 2634-4416

URL: Article

DOI: 10.1093/psyrad/kkac005

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2022

detail.hit.zdb_id: 3076092-6

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DataSheet_1.docx

Zhu, Hong-Hu ; Ma, Ya-Fang ; Yu, Kang ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Oncology Vol. 11 ( 2021-11-16)

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In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-11-16)

Abstract: Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in the real world. We conducted a population-based study of all APL patients in Zhejiang Province, China, with a total population of 82 million people, to assess the generalization of all-trans retinoic acid (ATRA) and arsenic as front-line treatment. The outcomes of APL patients were also analyzed. Between January 2015 and December 2019, 1,233 eligible patients were included in the final analysis. The rate of ATRA and arsenic as front-line treatment increased steadily from 66.2% in 2015 to 83.3% in 2019, with no difference among the size of the center (≥5 or & lt;5 patients per year, p = 0.12) or age (≥60 or & lt;60 years, p = 0.35). The early death (ED) rate, defined as death within 30 days after diagnosis, was 8.2%, and the 3-year overall survival (OS) was 87.9% in the whole patient population. Age (≥60 years) and white blood cell count ( & gt;10 × 10 9 /L) were independent risk factors for ED and OS in the multivariate analysis. This population-based study showed that ATRA and arsenic as front-line treatment are widely used under real-world conditions and yield a low ED rate and a high survival rate, which mimic the results from clinical trials, thereby supporting the wider application of APL guidelines in the future.

Type of Medium: Online Resource

ISSN: 2234-943X

URL: Article

DOI: 10.3389/fonc.2021.762653

DOI: 10.3389/fonc.2021.762653.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2649216-7

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High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program

Zhou, Xiao-Yang ; Zhu, Fa-Ming ; Li, Jian-Ping ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 9 ( 2015-9-30), p. e0139485-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 9 ( 2015-9-30), p. e0139485-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0139485

DOI: 10.1371/journal.pone.0139485.g001

DOI: 10.1371/journal.pone.0139485.g002

DOI: 10.1371/journal.pone.0139485.g003

DOI: 10.1371/journal.pone.0139485.g004

DOI: 10.1371/journal.pone.0139485.t001

DOI: 10.1371/journal.pone.0139485.t002

DOI: 10.1371/journal.pone.0139485.t003

DOI: 10.1371/journal.pone.0139485.t004

DOI: 10.1371/journal.pone.0139485.t005

DOI: 10.1371/journal.pone.0139485.t006

DOI: 10.1371/journal.pone.0139485.s001

DOI: 10.1371/journal.pone.0139485.s002

DOI: 10.1371/journal.pone.0139485.s003

DOI: 10.1371/journal.pone.0139485.s004

DOI: 10.1371/journal.pone.0139485.s005

DOI: 10.1371/journal.pone.0139485.s006

DOI: 10.1371/journal.pone.0139485.s007

DOI: 10.1371/journal.pone.0139485.s008

DOI: 10.1371/journal.pone.0139485.s009

DOI: 10.1371/journal.pone.0139485.s010

DOI: 10.1371/journal.pone.0139485.s011

DOI: 10.1371/journal.pone.0139485.s012

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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HLA-B*07, HLA-DRB1*07, HLA-DRB1*12, and HLA-C*03:02 Strongly Associate With BMI: Data From 1.3 Million Healthy Chinese Adults

Shen, Jie ; Guo, Tingwei ; Wang, Tao ; [et al.]

American Diabetes Association ; 2018

In: Diabetes Vol. 67, No. 5 ( 2018-05-01), p. 861-871

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In: Diabetes, American Diabetes Association, Vol. 67, No. 5 ( 2018-05-01), p. 861-871

Abstract: Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with BMI using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). We found 23 HLA alleles, including 12 low-resolution and 11 high-resolution alleles, were significantly associated with BMI after correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B*07, DRB1*07, DRB1*12, and C*03:02 provided the strongest associations with BMI (P = 6.89 × 10−10, 1.32 × 10−9, 1.52 × 10−9, and 4.45 × 10−8, respectively), where B*07 and DRB1*07 also had evidence for sex-specific effects (Pheterogeneity = 0.0067 and 0.00058, respectively). These results, which identify associations between alleles of HLA-B, DRB1, and C with BMI in Chinese young adults, implicate a novel biological connection between HLA alleles and obesity.

Type of Medium: Online Resource

ISSN: 0012-1797 , 1939-327X

URL: Article

DOI: 10.2337/db17-0852

Language: English

Publisher: American Diabetes Association

Publication Date: 2018

detail.hit.zdb_id: 1501252-9

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Introduction to the CDEX experiment

Kang, Ke-Jun ; CDEX Collaboration ; Cheng, Jian-Ping ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Frontiers of Physics Vol. 8, No. 4 ( 2013-8), p. 412-437

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In: Frontiers of Physics, Springer Science and Business Media LLC, Vol. 8, No. 4 ( 2013-8), p. 412-437

Type of Medium: Online Resource

ISSN: 2095-0462 , 2095-0470

URL: Article

DOI: 10.1007/s11467-013-0349-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2635767-7

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Limits on light WIMPs with a 1 kg-scale germanium detector at 160 eVee physics threshold at the China Jinping Underground Laboratory

Yang, Li-Tao ; Li, Hau-Bin ; Yue, Qian ; [et al.]

IOP Publishing ; 2018

In: Chinese Physics C Vol. 42, No. 2 ( 2018-01), p. 023002-

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In: Chinese Physics C, IOP Publishing, Vol. 42, No. 2 ( 2018-01), p. 023002-

Type of Medium: Online Resource

ISSN: 1674-1137

URL: Article

DOI: 10.1088/1674-1137/42/2/023002

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2018

detail.hit.zdb_id: 2491278-5

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Salvage tigecycline in high risk febrile neutropenic patients with hematological malignancies: a prospective multicenter study

Zhou, Xin-Ping ; Ye, Xiu-Jin ; Shen, Jian-Ping ; [et al.]

Informa UK Limited ; 2018

In: Leukemia & Lymphoma Vol. 59, No. 11 ( 2018-11-02), p. 2679-2685

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In: Leukemia & Lymphoma, Informa UK Limited, Vol. 59, No. 11 ( 2018-11-02), p. 2679-2685

Type of Medium: Online Resource

ISSN: 1042-8194 , 1029-2403

URL: Article

DOI: 10.1080/10428194.2018.1436173

Language: English

Publisher: Informa UK Limited

Publication Date: 2018

detail.hit.zdb_id: 2030637-4

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CDEX-1 1 kg point-contact germanium detector for low mass dark matter searches

Kang, Ke-Jun ; Yue, Qian ; Wu, Yu-Cheng ; [et al.]

IOP Publishing ; 2013

In: Chinese Physics C Vol. 37, No. 12 ( 2013-12), p. 126002-

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In: Chinese Physics C, IOP Publishing, Vol. 37, No. 12 ( 2013-12), p. 126002-

Type of Medium: Online Resource

ISSN: 1674-1137

URL: Article

DOI: 10.1088/1674-1137/37/12/126002

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2013

detail.hit.zdb_id: 2491278-5

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Study of the material photon and electron background and the liquid argon detector veto efficiency of the CDEX-10 experiment

Su, Jian ; Zeng, Zhi ; Ma, Hao ; [et al.]

IOP Publishing ; 2015

In: Chinese Physics C Vol. 39, No. 3 ( 2015-03), p. 036001-

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In: Chinese Physics C, IOP Publishing, Vol. 39, No. 3 ( 2015-03), p. 036001-

Type of Medium: Online Resource

ISSN: 1674-1137

URL: Article

DOI: 10.1088/1674-1137/39/3/036001

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2015

detail.hit.zdb_id: 2491278-5

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