In:
Angewandte Chemie, Wiley, Vol. 130, No. 12 ( 2018-03-12), p. 3123-3127
Abstract:
The first total syntheses of the bioactive cyclodepsipeptides ohmyungsamycin A and B are described. Key features of our synthesis include the concise preparation of a linear cyclization precursor that consists of N ‐methyl amides and non‐proteinogenic amino acids, and its macrolactamization from a bent conformation. The proposed structure of ohmyungsamycin B was revised based on its synthesis. The cyclic core of the ohmyungsamycins was shown to be responsible for the excellent antituberculosis activity, and ohmyungsamycin variants with truncated chains were evaluated for their biological activity.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.12
DOI:
10.1002/ange.201711286
Language:
English
Publisher:
Wiley
Publication Date:
2018
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505872-7
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1479266-7
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