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1

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators

Yang, Feng V. ; Shipe, William D. ; Bunda, Jaime L. ; [et al.]

Elsevier BV ; 2010

In: Bioorganic & Medicinal Chemistry Letters Vol. 20, No. 2 ( 2010-01), p. 531-536

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 20, No. 2 ( 2010-01), p. 531-536

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2009.11.100

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2010

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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2

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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia

Raheem, Izzat T. ; Schreier, John D. ; Fuerst, Joy ; [et al.]

Elsevier BV ; 2016

In: Bioorganic & Medicinal Chemistry Letters Vol. 26, No. 1 ( 2016-01), p. 126-132

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 26, No. 1 ( 2016-01), p. 126-132

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2015.11.013

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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3

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Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

Yang, Zhi-Qiang ; Barrow, James C. ; Shipe, William D. ; [et al.]

American Chemical Society (ACS) ; 2008

In: Journal of Medicinal Chemistry Vol. 51, No. 20 ( 2008-10-23), p. 6471-6477

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 51, No. 20 ( 2008-10-23), p. 6471-6477

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm800830n

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2008

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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4

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The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design

Forster, Ashley B. ; Abeywickrema, Pravien ; Bunda, Jaime ; [et al.]

Elsevier BV ; 2017

In: Bioorganic & Medicinal Chemistry Letters Vol. 27, No. 23 ( 2017-12), p. 5167-5171

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 27, No. 23 ( 2017-12), p. 5167-5171

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2017.10.054

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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5

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Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca 2+ Channel Antagonist

Shipe, William D. ; Barrow, James C. ; Yang, Zhi-Qiang ; [et al.]

American Chemical Society (ACS) ; 2008

In: Journal of Medicinal Chemistry Vol. 51, No. 13 ( 2008-07), p. 3692-3695

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 51, No. 13 ( 2008-07), p. 3692-3695

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm800419w

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2008

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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6

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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

Shipe, William D. ; Sharik, Steven S. ; Barrow, James C. ; [et al.]

American Chemical Society (ACS) ; 2015

In: Journal of Medicinal Chemistry Vol. 58, No. 19 ( 2015-10-08), p. 7888-7894

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 58, No. 19 ( 2015-10-08), p. 7888-7894

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.5b00983

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2015

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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7

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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

Layton, Mark E. ; Kern, Jeffrey C. ; Hartingh, Timothy J. ; [et al.]

American Chemical Society (ACS) ; 2023

In: Journal of Medicinal Chemistry Vol. 66, No. 2 ( 2023-01-26), p. 1157-1171

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 66, No. 2 ( 2023-01-26), p. 1157-1171

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.2c01521

DOI: 10.1021/acs.jmedchem.2c01521.s001

DOI: 10.1021/acs.jmedchem.2c01521.s002

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2023

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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8

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Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

Bungard, Christopher J. ; Williams, Peter D. ; Ballard, Jeanine E. ; [et al.]

American Chemical Society (ACS) ; 2016

In: ACS Medicinal Chemistry Letters Vol. 7, No. 7 ( 2016-07-14), p. 702-707

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In: ACS Medicinal Chemistry Letters, American Chemical Society (ACS), Vol. 7, No. 7 ( 2016-07-14), p. 702-707

Type of Medium: Online Resource

ISSN: 1948-5875 , 1948-5875

URL: Article

DOI: 10.1021/acsmedchemlett.6b00135

DOI: 10.1021/acsmedchemlett.6b00135.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2016

detail.hit.zdb_id: 2532386-6

SSG: 15,3

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9

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles : Miniperspective

Sanders, John M. ; Beshore, Douglas C. ; Culberson, J. Christopher ; [et al.]

American Chemical Society (ACS) ; 2017

In: Journal of Medicinal Chemistry Vol. 60, No. 16 ( 2017-08-24), p. 6771-6780

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 60, No. 16 ( 2017-08-24), p. 6771-6780

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.6b01577

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2017

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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10

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A Convergent Synthesis of the Tricyclic Architecture of the Guanacastepenes Featuring a Selective Ring Fragmentation

Shipe, William D. ; Sorensen, Erik J.

American Chemical Society (ACS) ; 2002

In: Organic Letters Vol. 4, No. 12 ( 2002-06-01), p. 2063-2066

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In: Organic Letters, American Chemical Society (ACS), Vol. 4, No. 12 ( 2002-06-01), p. 2063-2066

Type of Medium: Online Resource

ISSN: 1523-7060 , 1523-7052

URL: Article

DOI: 10.1021/ol0259342

RVK:

VA 6250

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2002

detail.hit.zdb_id: 1501522-1

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Berlin Brandenburg