In:
International Journal of Otolaryngology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-9
Abstract:
We evaluated a panel of 8 immunohistochemical biomarkers as predictors of clinical response to definitive intensity-modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma (OPSCC). 106 patients with OPSCC were treated to a total dose of 66–70 Gy and retrospectively analyzed for locoregional control (LRC), disease-free survival (DFS), and overall survival (OS). All tumors had p16 immunohistochemical staining, and 101 tumors also had epidermal growth factor receptor (EGFR) staining. 53% of the patients had sufficient archived pathologic specimens for incorporation into a tissue microarray for immunohistochemical analysis for cyclophilin B, cyclin D1, p21, hypoxia-inducible factor-1 α (HIF-1 α ), carbonic anhydrase, and major vault protein. Median followup was 27.2 months. 66% of the tumors were p16 positive, and 34% were p16 negative. On univariate analysis, the following correlations were statistically significant: p16 positive staining with higher LRC ( P = 0.005 ) and longer DFS ( P 〈 0.001 ); cyclin D1 positive staining with lower LRC ( P = 0.033 ) and shorter DFS ( P = 0.002 ); HIF-1 α positive staining with shorter DFS ( P = 0.039 ). On multivariate analysis, p16 was the only significant independent predictor of DFS ( P = 0.023 ). After immunohistochemical examination of a panel of 8 biomarkers, our study could only verify p16 as an independent prognostic factor in OPSCC.
Type of Medium:
Online Resource
ISSN:
1687-9201
,
1687-921X
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2503281-1
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