In:
Metal-Based Drugs, Hindawi Limited, Vol. 9, No. 1-2 ( 2002-01-01), p. 109-118
Abstract:
Thiiobenzyhdrazide (Htbh) and its Cu(II) complexes, [ Cu ( Htbh ) 2 Cl 2 ] and [ Cu ( tbh ) 2 ] were synthesized and
characterized by various physicochemical studies. In vivo and in vitro antitumour activity of Htbh, [ Cu ( Htbh ) 2 Cl 2 ] and [ Cu ( tbh ) 2 ] has been tested. LD 50 values were calculated for all the three compounds. It
was observed that the antitumour effect of [ Cu ( Htbh ) 2 Cl 2 ] is maximum. Light microscopic study of the
treated tumour mass demonstrated that certain cellular degradation, such as disappearance of mitotic figures, loss in cellular compactness, distortion of nucleus and disruption of cytoplasmic boundaries, takes place in
the tumour region of complex treated mice. Further, tumour bearing mice administered with Cu(II) complexes showed reversal of tumour growth associated induction of apoptosis in lymphocytes.
Type of Medium:
Online Resource
ISSN:
0793-0291
DOI:
10.1155/MBD.2002.109
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2002
detail.hit.zdb_id:
2392146-8
SSG:
15,3
Bookmarklink