In:
International Journal of Cancer, Wiley, Vol. 136, No. 6 ( 2015-03-15), p. 1296-1307
Abstract:
What's new? Melanoma often metastasizes to the brain, but if researchers could find out how it does so, perhaps they could prevent it. Cells poised to metastasize often reveal themselves by molecular clues, and indeed, melanoma cells likely to infiltrate the brain express less of the tight‐junction protein CLDN1 than other melanoma cells. In this study, the authors showed that when melanoma cells express extra CLDN1, they could not form micro‐metastases in the brain – though their ability to metastasize to the lungs was not impaired. Thus, CLDN1 expression could help predict the likelihood of brain metastasis, and targeting cells expressing low levels of the protein could help prevent or treat this deadly complication.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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