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Abstract 1714: The role and mechanism of JAB1 as a therapeutic target in biliary tract cancer

Nam, Ah-Rong ; Kang, Kyo Hwa ; Park, Ji Eun ; [et al.]

American Association for Cancer Research (AACR) ; 2015

In: Cancer Research Vol. 75, No. 15_Supplement ( 2015-08-01), p. 1714-1714

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In: Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 15_Supplement ( 2015-08-01), p. 1714-1714

Abstract: Background: JAB1 (c-Jun activation domain binding protein-1) is a c-Jun coactivator, also known as COP9 signalosome subunit 5 (CSN5). Jab1 has an important role in cell proliferation and apoptosis. Overexpression of Jab1 is correlated with poor prognosis in various cancers. Biliary tract cancer (BTC) has a poor prognosis with a huge unmet medical need. The role of Jab1 has not been studied in BTC. We investigated the role and mechanism of Jab1 as a potential therapeutic target in BTC. Methods: We used 8 kinds of BTC cells and designed Jab1 siRNA. MTT assay and colony formation assay were done to determine growth inhibitory effect of Jab1 knockdown. Cell cycle analysis was done by FACS Calibur flow cytometer and cell migration was evaluated by wound healing assay. We used cycloheximide chase assay for measuring of protein half-life. Results: BTC cell lines showed high level of Jab1 expression. Among them, SNU478, SNU869 and SNU 1196 were indicated with especially higher level of Jab1 expression. Cell growth and proliferation of BTC cells were decreased by Jab1 knockdown. Depletion of Jab1 induced G1 arrest, as well as decreased CyclinD/CyclinA and increased p27. Cell migration was also inhibited by Jab1 knockdown. Inhibition of Jab1 showed the decrease of pSrc, pAkt. Interestingly, depletion of Jab1 led to the elevation of PTEN protein levels without change of PTEN mRNA levels. PTEN half-life was longer in Jab1 siRNA-transfected cells. Suppression of Jab1 increased the sensitivity of BTC cells to the cytotoxic chemotherapeutic agent. Conclusion: Suppression of Jab1 shows antitumor effects in BTC cells by inhibiting cell proliferation, migration, cell cycle and increase of chemosensitivity. Taken together, Jab1 might be a potential therapeutic target in BTC. Citation Format: Ah-Rong Nam, Kyo Hwa Kang, Ji Eun Park, Ju-Hee Bang, Ling Jin, Mei Hua Jin, Tae Yong Kim, Sae-Won Han, Sang-Hyun Song, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang. The role and mechanism of JAB1 as a therapeutic target in biliary tract cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1714. doi:10.1158/1538-7445.AM2015-1714

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/1538-7445.AM2015-1714

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2015

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

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Abstract 3599: Resistance mechanisms to HER2-targeting treatment in HER2-positive gastric cancer

Kang, Kyo Hwa ; Nam, Ah-Rong ; Park, Ji Eun ; [et al.]

American Association for Cancer Research (AACR) ; 2015

In: Cancer Research Vol. 75, No. 15_Supplement ( 2015-08-01), p. 3599-3599

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In: Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 15_Supplement ( 2015-08-01), p. 3599-3599

Abstract: Background: HER2 is the first validated therapeutic target in advanced gastric cancer (GC). Trastuzumab in combination with chemotherapy is used as a first-line treatment of GC. The resistance mechanisms to trastuzumab have not been widely known in GC. We investigated the resistance mechanisms to HER2-targeting agents in HER2-positive gastric cancer cells. Methods: SNU216 and NCI-N87 are HER2 amplified gastric cancer cells. Using these cells, we established trastuzumab-resistant cells (SNU216-HR, N87-HR) and dacomitinib (panHER inhibitor)-resistant cells (SNU216-PR). Acquired resistance of the established cell lines was verified by MTT assay and western blotting. We compared various receptor tyrosine kinase activities and protein expression levels between parental and resistant cells by RTK arrays and western blotting. We used many targeted agents (HER family inhibitor, PI3K inhibitor, mTOR inhibitor, MEK inhibitor, Src inhibitor, HSP90 inhibitor, etc) to overcome the resistance. Results: Resistant cells displayed more rapid growth rate and different morphology compared with parent cells. Resistant cells showed increased levels of pEGFR, pHER2, pHER3, pMET, pIGF1R, pAXL, pSTAT3, pAKT, pFAK, and TS compared with the parental cells in western blot. With the treatment of trastuzumab, HR cells showed elevated levels of EGFR, pHER2, AXL, pAXL, pMEK, pSRC, pSTAT3, pAKT, pERK and TS compared with the parental cells. With the treatment of dacominitib, PR cells showed elevated levels of pEGFR, pAXL, pIGF1R, pMEK, pSRC, pERK and TS compared with the parental cells in western blot. The RTK arrays also showed the similar findings. These resistant cells were more sensitive to Src inhibitor and PI3K inhibitor than parent cells. Conclusion: Resistance mechanisms to HER2-targeting strategy in gastric cancer include activation of HER, MET, FAK and Src pathway. Targeting these pathways is needed to overcome resistance. Citation Format: Kyo Hwa Kang, Ah-Rong Nam, Ji Eun Park, Ju-Hee Bang, Jin Ling, Mei Hua Jin, Tae Yong Kim, Sae-Won Han, Sang-Hyun Song, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang. Resistance mechanisms to HER2-targeting treatment in HER2-positive gastric cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3599. doi:10.1158/1538-7445.AM2015-3599

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/1538-7445.AM2015-3599

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2015

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

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Terahertz emission from Y〈sub〉3〈/sub〉Fe〈sub〉5〈/sub〉O〈sub〉12〈/sub〉(YIG)/Pt heterostructures via ultrafast spin Seebeck effect

Song, Bang-Ju ; Jin, Zuan-Ming ; Guo, Chen-Yang ; [et al.]

Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2020

In: Acta Physica Sinica Vol. 69, No. 20 ( 2020), p. 208704-

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In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 69, No. 20 ( 2020), p. 208704-

Abstract: Recently, ferromagnetic/non-magnetic heterostructures have been widely studied for the generation of terahertz (THz) emitter based on spin-to-charge conversion. Actually, thermal spintronics effectively combines thermal transport with magnetism for creating and detecting non-equilibrium spin transport. A spin current or voltage can be induced by a temperature bias applied to a ferromagnetic material, which is called spin Seebeck effect (SSE). In this paper, we present a SSE based THz emission by using the heterostructures made of insulating ferrimagnet yttrium iron garnet (Y〈sub〉3〈/sub〉Fe〈sub〉5〈/sub〉O〈sub〉12〈/sub〉, YIG) and platinum (Pt) with large spin orbit coupling. Upon exciting the Pt layer with a femtosecond laser pulse, a spin Seebeck current arises, applying a temperature gradient to the interface. Based on the inverse spin Hall effect, the spin Seebeck current is converted into a transient charge current and then yields the THz transients, which are detected by electrooptic sampling through using a ZnTe crystal at room temperature. The polarity of the THz pulses is flipped by 180° when the direction of the external magnetic field is reversed. By changing the direction of the pump beam excitation geometry to vary the sign of the temperature gradient at the YIG/Pt interface, the polarity of the THz signal is reversed. Fast Fourier transformation of the THz signals yields the amplitude spectra centered near 0.6 THz with a bandwidth in a range of 0.1–2.5 THz. We systematically investigate the influence of annealing effect on the THz emission from different YIG/Pt heterostructures. It can be found that the THz radiation is achieved to increase ten times in the YIG/Pt grown on a Gd〈sub〉3〈/sub〉Ga〈sub〉5〈/sub〉O〈sub〉12 〈/sub〉(GGG) substrate through high-temperature annealing. The mechanism of annealing effect can be the increase of the spin mixing conductance of the interface between YIG and Pt. Finally, we investigate the pump fluence dependent THz peak-to-peak values for the annealed YIG/Pt grown on the Si substrate. Due to the spin accumulation effect at the interface of the YIG/Pt heterostructure, the THz radiation intensity gradually becomes saturated with the increase of pump fluence. Our results conclude that annealing optimization is of importance for increasing the THz amplitude, and open a new avenue to the future applications of spintronic THz emitters based on ultrafast SSE.

Type of Medium: Online Resource

ISSN: 1000-3290 , 1000-3290

URL: Journal

URL: Article

DOI: 10.7498/aps

DOI: 10.7498/aps.69.20200733

Language: Unknown

Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences

Publication Date: 2020

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Fabrication of Nanostructured 3FeAl-Al2O3 Composite from Mechanically Synthesized Powders by Pulsed Current Activated Sintering and Its Mechanical Properties

Shon, In-Jin ; Du, Song-Lee ; Doh, Jung-Mann ; [et al.]

The Korean Institute of Metals and Materials ; 2012

In: Korean Journal of Metals and Materials Vol. 50, No. 6 ( 2012-6-5), p. 449-454

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In: Korean Journal of Metals and Materials, The Korean Institute of Metals and Materials, Vol. 50, No. 6 ( 2012-6-5), p. 449-454

Type of Medium: Online Resource

ISSN: 1738-8228 , 2288-8241

Uniform Title: 기계적 합성된 분말로부터 펄스전류 활성 소결에 의한 나노구조 3FeAl-Al2O3 복합재료 제조 및 기계적 특성

URL: Issue

URL: Journal

URL: Article

DOI: 10.3365/KJMM.2012.50.6.

DOI: 10.3365/KJMM.2016.

DOI: 10.3365/KJMM.2012.50.6.449

Language: Unknown

Publisher: The Korean Institute of Metals and Materials

Publication Date: 2012

detail.hit.zdb_id: 2841186-9

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Serum Concentration of Nitrotyrosine as Indicator of Disease Progress in Dogs with Myxomatous Mitral Valve Disease

Bang, Ju-Hwan ; Park, Jun-Seok ; Seo, Kyoung-Won ; [et al.]

The Korean Society of Veterinary Clinics ; 2019

In: Journal of Veterinary Clinics Vol. 36, No. 2 ( 2019-04-30), p. 102-105

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In: Journal of Veterinary Clinics, The Korean Society of Veterinary Clinics, Vol. 36, No. 2 ( 2019-04-30), p. 102-105

Type of Medium: Online Resource

ISSN: 1598-298X , 2384-0749

URL: Article

DOI: 10.17555/jvc.2019.04.36.2.102

Language: English

Publisher: The Korean Society of Veterinary Clinics

Publication Date: 2019

detail.hit.zdb_id: 2862604-7

SSG: 22

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Gemcitabine and cisplatin plus durvalumab with or without tremelimumab in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, single-centre, phase 2 study

Oh, Do-Youn ; Lee, Kyung-Hun ; Lee, Dae-Won ; [et al.]

Elsevier BV ; 2022

In: The Lancet Gastroenterology & Hepatology Vol. 7, No. 6 ( 2022-06), p. 522-532

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In: The Lancet Gastroenterology & Hepatology, Elsevier BV, Vol. 7, No. 6 ( 2022-06), p. 522-532

Type of Medium: Online Resource

ISSN: 2468-1253

URL: Article

DOI: 10.1016/S2468-1253(22)00043-7

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication

Jin, Seong Eun ; Kim, Jung-Eun ; Kim, Sun Yeou ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Journal of Microbiology Vol. 55, No. 12 ( 2017-12), p. 984-988

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In: Journal of Microbiology, Springer Science and Business Media LLC, Vol. 55, No. 12 ( 2017-12), p. 984-988

Type of Medium: Online Resource

ISSN: 1225-8873 , 1976-3794

URL: Article

DOI: 10.1007/s12275-017-7477-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2441367-7

SSG: 12

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Identification of Renoprotective Phytosterols from Mulberry (Morus alba) Fruit against Cisplatin-Induced Cytotoxicity in LLC-PK1 Kidney Cells

Lee, Dahae ; Lee, Seoung Rak ; Park, Bang Ju ; [et al.]

MDPI AG ; 2021

In: Plants Vol. 10, No. 11 ( 2021-11-17), p. 2481-

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In: Plants, MDPI AG, Vol. 10, No. 11 ( 2021-11-17), p. 2481-

Abstract: The aim of this study was to explore the protective effects of bioactive compounds from the fruit of the mulberry tree (Morus alba L.) against cisplatin-induced apoptosis in LLC-PK1 pig kidney epithelial cells. Morus alba fruit is a well-known edible fruit commonly used in traditional folk medicine. Chemical investigation of M. alba fruit resulted in the isolation and identification of six phytosterols (1–6). Their structures were determined as 7-ketositosterol (1), stigmast-4-en-3β-ol-6-one (2), (3β,6α)-stigmast-4-ene-3,6-diol (3), stigmast-4-ene-3β,6β-diol (4), 7β-hydroxysitosterol 3-O-β-d-glucoside (5), and 7α-hydroxysitosterol 3-O-β-d-glucoside (6) by analyzing their physical and spectroscopic data as well as liquid chromatography/mass spectrometry data. All compounds displayed protective effects against cisplatin-induced LLC-PK1 cell damage, improving cisplatin-induced cytotoxicity to more than 80% of the control value. Compound 1 displayed the best effect at a relatively low concentration by inhibiting the percentage of apoptotic cells following cisplatin treatment. Its molecular mechanisms were identified using Western blot assays. Treatment of LLC-PK1 cells with compound 1 decreased the upregulated phosphorylation of p38 and c-Jun N-terminal kinase (JNK) following cisplatin treatment. In addition, compound 1 significantly suppressed cleaved caspase-3 in cisplatin-induced LLC-PK1 cells. Taken together, these findings indicated that cisplatin-induced apoptosis was significantly inhibited by compound 1 in LLC-PK1 cells, thereby supporting the potential of 7-ketositosterol (1) as an adjuvant candidate for treating cisplatin-induced nephrotoxicity.

Type of Medium: Online Resource

ISSN: 2223-7747

URL: Article

DOI: 10.3390/plants10112481

Language: English

Publisher: MDPI AG

Publication Date: 2021

detail.hit.zdb_id: 2704341-1

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A Study on the Buddhist View of Humanity and the Methods of Dialogue

Song, Bang-ju(Hechun) ; Korean Buddhist Counselling Society

Korean Buddhist Counselling Society ; 2023

In: Korean Buddhist Counselling Society Vol. 18 ( 2023-12-31), p. 165-183

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In: Korean Buddhist Counselling Society, Korean Buddhist Counselling Society, Vol. 18 ( 2023-12-31), p. 165-183

Abstract: Buddhism is a human-centered religion. The Buddha emphasized coexistence, interdependent relationships, and the good nature of human beings. Knowing the reality and origin of suffering, overcoming it, and achieving happiness and enlightenment as the ultimate goal is a characteristic of Buddhism. This paper is a study on the Buddhist view of human beings and the use of dialogue methods. The possibility of communication that empathizes with the pain of the other person, the possibility of positive evolution, and the possibility of pursuing true happiness and satisfaction were examined. The Buddhist view of humanity is based on a critique of the caste system in ancient Indian society, human values and karma, the concept of interdependence in familial relations, non-duality(自他不二, the oneness of self and others), the idea that all sentient beings possess Buddha-nature. Buddhist dialogue focuses on the use of right language. They are the avoidance of the lies, divisive speech, harsh speech, and idle chatter. This paper analyzes these ideas and discusses the use of Buddhism's "advising method" and "dagisullbub(對機說法)." The possibility of respect and understanding of the other person was examined, and the possibility of peaceful dialogue was examined through understanding and tolerance of negative emotions and behaviors. Buddhism teaches us to have a conversation in a state of mental calm. Teach empathy and communication with the other person's pain. Emphasizing practice and compassion, it emphasizes that adherence to ethical principles can lead to individuals and societies evolving for the better, and to find true happiness and contentment. By faithfully practicing these basic Buddhist tenets, you will be able to use the basic principles of interpersonal relationships and communication techniques. The purpose of this study is to find out that this Buddhist methodology can help solve various psychological problems in modern society.

Type of Medium: Online Resource

ISSN: 2508-6987

Uniform Title: 불교의 인간관과 대화법에 관한 연구

URL: Issue

URL: Journal

URL: Article

DOI: 10.35855/KBCA.2023.18.

DOI: 10.35855/KBCA.

DOI: 10.35855/KBCA.2023.18.06

Language: Unknown

Publisher: Korean Buddhist Counselling Society

Publication Date: 2023

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Spicatoside A derived from Liriope platyphylla root ethanol extract inhibits hepatitis E virus genotype 3 replication in vitro

Park, Gayoung ; Parveen, Amna ; Kim, Jung-Eun ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Scientific Reports Vol. 9, No. 1 ( 2019-03-13)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-03-13)

Abstract: Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans worldwide. Although hepatitis E is self-limiting without chronic infection development, HEV infection often leads to severe liver diseases causing high mortality in pregnant women in addition to chronic hepatitis and cirrhosis in immunosuppressed patients. In this study, we investigated the effect of a Liriope platyphylla ethanol extract (LPE) on HEV replication. Interestingly, LPE suppressed replication of the genotype 3 HEV replicon. Sequential solvent fractionation revealed that the ethyl acetate (EA) fraction of LPE exerts the most potent inhibitory effects. With the aid of activity-guided fractionation and multi-step column chromatography, spicatoside A was subsequently isolated in the EA fraction of LPE and specifically shown to exert inhibitory effects on replication of the genotype 3 HEV replicon. In addition, spicatoside A interfered with replication of the HEV genotype 3 strain 47832c and expression of HEV ORF2 capsid proteins. Our findings clearly support the potential utility of spicatoside A as an effective anti-HEV agent.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-019-39488-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2615211-3

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