In:
Angewandte Chemie, Wiley, Vol. 130, No. 18 ( 2018-04-23), p. 4996-5000
Abstract:
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O 2 into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with . OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO 2 is reported that has both Fenton‐like Mn 2+ delivery and GSH depletion properties. In the presence of HCO 3 − , which is abundant in the physiological medium, Mn 2+ exerts Fenton‐like activity to generate . OH from H 2 O 2 . Upon uptake of MnO 2 ‐coated mesoporous silica nanoparticles (MS@MnO 2 NPs) by cancer cells, the MnO 2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn 2+ , resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO 2 , allows MS@MnO 2 NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.18
DOI:
10.1002/ange.201712027
Language:
English
Publisher:
Wiley
Publication Date:
2018
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