In:
Frontiers in Photonics, Frontiers Media SA, Vol. 3 ( 2023-1-5)
Abstract:
Gastrointestinal cancers continue to account for a disproportionately large percentage of annual cancer deaths in the United States. Advancements in miniature imaging technology combined with a need for precise and thorough tumor detection in gastrointestinal cancer screenings fuel the demand for new, small-scale, and low-cost methods of localization and margin identification with improved accuracy. Here, we report the development of a miniaturized, chip-on-tip, multispectral, fluorescence imaging probe designed for compatibility with a gastroscope working channel with the aim of detecting cancerous lesions in point-of-care endoscopy of the gastrointestinal lumen. Preclinical testing has confirmed fluorescence sensitivity and supports that this miniature probe can locate structures of interest via detection of fluorescence emission from exogenous contrast agents. This work demonstrates the design and preliminary performance evaluation of a miniaturized, single-use, chip-on-tip fluorescence imaging system, capable of detecting multiplexed fluorophores, and devised for deployment via the accessory channel of a standard gastroscope.
Type of Medium:
Online Resource
ISSN:
2673-6853
DOI:
10.3389/fphot.2022.1067651
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
3112910-9
Bookmarklink
