In:
Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 224, No. 6 ( 2004-03-01), p. 887-891
Abstract:
Objective —To determine the biological behavior of
liposarcomas in dogs and identify clinical signs, the effect of treatment on survival time, and potential
prognostic factors. Design —Retrospective study. Animals —56 dogs with histologically confirmed liposarcoma. Procedure —Information was obtained on signalment,
tumor size, location of the tumor, stage of disease, remission duration, overall survival time, cause
of death, type of surgery (incisional biopsy, marginal excision, or wide excision), and any additional treatments
given. Results —Surgery consisted of incisional biopsy in 6
dogs, marginal excision in 34, and wide excision in 16. Twenty-five dogs had histologic evidence of tumor
cells at the surgical margins and 28 did not (status of the margins was unknown in 3 dogs). Twelve of 43
dogs had local recurrence. Median survival time was 694 days, and the only factor significantly associated
with survival time was type of surgery performed. Median survival times were 1,188, 649, and 183 days,
respectively, for dogs that underwent wide excision, marginal excision, and incisional biopsy. Factors that
were not found to be significantly associated with survival time included tumor size, status of the margins,
tumor location, and histologic subtype. Conclusions and Clinical Relevance —Results suggest
that in dogs, liposarcomas are locally invasive neoplasms that rarely metastasize and occur primarily
in appendicular or axial locations and that wide excision is preferred to marginal excision when feasible.
( J Am Vet Med Assoc 2004;224:887–891)
Type of Medium:
Online Resource
ISSN:
0003-1488
DOI:
10.2460/javma.2004.224.887
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2004
detail.hit.zdb_id:
2904887-4
SSG:
22
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