In:
Journal of Comparative Effectiveness Research, Becaris Publishing Limited, Vol. 9, No. 8 ( 2020-06), p. 563-571
Abstract:
Aim: To assess the potential of biomarker triage testing (BM-TT) in the Dutch colorectal cancer (CRC) screening program. Materials & methods: Using the Adenoma and Serrated pathway to Colorectal CAncer model, we simulated fecal immunochemical test (FIT) 47 -screening and various FIT plus BM-TT screening scenarios in which only individuals with both a positive FIT and BM-TT are referred to colonoscopy. Results: Adding a low polyp sensitivity BM-TT to FIT-screening reduced colonoscopy burden (89–100%) while increasing CRC mortality (27–41%) compared with FIT 47 -screening only. The FIT plus high polyp sensitivity BM-TT scenarios also decreased colonoscopy burden (71–89%) while hardly affecting CRC mortality (FIT 47 0–4% increase, FIT 15 2–7% decrease). Conclusion: Adding a BM-TT to FIT-screening considerably reduces colonoscopy burden, but could also decrease screening effectiveness. Combining FIT 15 with a high polyp sensitivity BM-TT seems most promising.
Type of Medium:
Online Resource
ISSN:
2042-6305
,
2042-6313
DOI:
10.2217/cer-2019-0130
Language:
English
Publisher:
Becaris Publishing Limited
Publication Date:
2020
detail.hit.zdb_id:
2669725-7
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