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  • 1
    In: JAMA Network Open, American Medical Association (AMA), Vol. 4, No. 12 ( 2021-12-15), p. e2138911-
    Abstract: With the global population aging, falls and fall-related injuries are ubiquitous, and several clinical practice guidelines for falls prevention and management for individuals 60 years or older have been developed. A systematic evaluation of the recommendations and agreement level is lacking. Objectives To perform a systematic review of clinical practice guidelines for falls prevention and management for adults 60 years or older in all settings (eg, community, acute care, and nursing homes), evaluate agreement in recommendations, and identify potential gaps. Evidence Review A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-analyses statement methods for clinical practice guidelines on fall prevention and management for older adults was conducted (updated July 1, 2021) using MEDLINE, PubMed, PsycINFO, Embase, CINAHL, the Cochrane Library, PEDro, and Epistemonikos databases. Medical Subject Headings search terms were related to falls, clinical practice guidelines, management and prevention, and older adults, with no restrictions on date, language, or setting for inclusion. Three independent reviewers selected records for full-text examination if they followed evidence- and consensus-based processes and assessed the quality of the guidelines using Appraisal of Guidelines for Research & amp;amp; Evaluation II (AGREE-II) criteria. The strength of the recommendations was evaluated using Grades of Recommendation, Assessment, Development, and Evaluation scores, and agreement across topic areas was assessed using the Fleiss κ statistic. Findings Of 11 414 records identified, 159 were fully reviewed and assessed for eligibility, and 15 were included. All 15 selected guidelines had high-quality AGREE-II total scores (mean [SD], 80.1% [5.6%] ), although individual quality domain scores for clinical applicability (mean [SD], 63.4% [11.4%] ) and stakeholder (clinicians, patients, or caregivers) involvement (mean [SD], 76.3% [9.0%] ) were lower. A total of 198 recommendations covering 16 topic areas in 15 guidelines were identified after screening 4767 abstracts that proceeded to 159 full texts. Most (≥11) guidelines strongly recommended performing risk stratification, assessment tests for gait and balance, fracture and osteoporosis management, multifactorial interventions, medication review, exercise promotion, environment modification, vision and footwear correction, referral to physiotherapy, and cardiovascular interventions. The strengths of the recommendations were inconsistent for vitamin D supplementation, addressing cognitive factors, and falls prevention education. Recommendations on use of hip protectors and digital technology or wearables were often missing. None of the examined guidelines included a patient or caregiver panel in their deliberations. Conclusions and Relevance This systematic review found that current clinical practice guidelines on fall prevention and management for older adults showed a high degree of agreement in several areas in which strong recommendations were made, whereas other topic areas did not achieve this level of consensus or coverage. Future guidelines should address clinical applicability of their recommendations and include perspectives of patients and other stakeholders.
    Type of Medium: Online Resource
    ISSN: 2574-3805
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2021
    detail.hit.zdb_id: 2931249-8
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  • 2
    In: Age and Ageing, Oxford University Press (OUP), Vol. 51, No. 9 ( 2022-09-02)
    Abstract: falls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs. Current guidelines are inconsistent, with no up-to-date, globally applicable ones present. Objectives to create a set of evidence- and expert consensus-based falls prevention and management recommendations applicable to older adults for use by healthcare and other professionals that consider: (i) a person-centred approach that includes the perspectives of older adults with lived experience, caregivers and other stakeholders; (ii) gaps in previous guidelines; (iii) recent developments in e-health and (iv) implementation across locations with limited access to resources such as low- and middle-income countries. Methods a steering committee and a worldwide multidisciplinary group of experts and stakeholders, including older adults, were assembled. Geriatrics and gerontological societies were represented. Using a modified Delphi process, recommendations from 11 topic-specific working groups (WGs), 10 ad-hoc WGs and a WG dealing with the perspectives of older adults were reviewed and refined. The final recommendations were determined by voting. Recommendations all older adults should be advised on falls prevention and physical activity. Opportunistic case finding for falls risk is recommended for community-dwelling older adults. Those considered at high risk should be offered a comprehensive multifactorial falls risk assessment with a view to co-design and implement personalised multidomain interventions. Other recommendations cover details of assessment and intervention components and combinations, and recommendations for specific settings and populations. Conclusions the core set of recommendations provided will require flexible implementation strategies that consider both local context and resources.
    Type of Medium: Online Resource
    ISSN: 0002-0729 , 1468-2834
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2065766-3
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  • 3
    In: Epilepsia, Wiley, Vol. 57, No. 3 ( 2016-03), p. 427-435
    Abstract: The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire ( QOLCE ‐55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Methods Data come from 373 children enrolled in the Health‐related Quality of Life in Children with Epilepsy Study ( HERQULES ), a multisite prospective cohort study. Measurement equivalence was examined using a multiple‐group confirmatory factor analysis framework, whereby increasingly stringent parameter constraints are imposed on the model. Comparison groups were stratified based on age (4–7 years vs. 8–12 years), sex (male vs. female), and time (measurement of health‐related quality of life at diagnosis vs. 24 months later). Results The QOLCE ‐55 demonstrated measurement equivalence at the level of strict invariance for each model tested—age: χ 2 (3,123) = 4,097.3, p 〈 0.001; Comparative Fit Index ( CFI ) = 0.968; Root Mean Square Error of Approximation ( RMSEA ) = 0.042 (0.038, 0.045); sex: χ 2 (3,124) = 4,188.3, p 〈 0.001; CFI = 0.964; RMSEA = 0.044 (0.040, 0.047); and time: χ 2 (3,121) = 5,185.0, p 〈 0.001; CFI = 0.965; RMSEA = 0.046 (0.043, 0.048). Significance These findings suggest that items comprising the QOLCE ‐55 are perceived similarly among groups stratified by age, sex, and time and provide further evidence supporting the validity of the scale in children with epilepsy. Health professionals and researchers should be confident that group comparisons made using the QOLCE ‐55 are unbiased and that any group differences detected are meaningful; that is, not related to differences in the interpretation of items by informants. Future research replicating these findings is encouraged.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2002194-X
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  • 4
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S11 ( 2022-12)
    Abstract: Multimorbidity is associated with cognitive decline. Little information exists regarding whether the relationship between multimorbidity and cognitive decline has changed over the last few decades. Objective To compare estimates of the association between multimorbidity (MM) and performance on cognitive tests in two prospective cohorts of Canadian community‐dwelling older adults recruited 24 years apart. Method We analyzed the two datasets separately, including participants ≥65 years from both baseline and first follow‐up of the Canadian Study of Health and Aging (CSHA, 1991 – 2001; first follow up in 1996) and the Canadian Longitudinal Study on Aging (CLSA, 2015 – ongoing; first follow up in 2018). We excluded participants with baseline dementia. In both cohorts, we defined MM as two or more conditions from a list of 14. The neuropsychological tests were Animal Naming Test (ANT) and the Rey Auditory Verbal Learning Test (RAVL) for both cohorts. Tests of frontal function were the Digit Symbol Substitution Test (DSST) in the CSHA and the Mental Alternation Task (MAT) in the CLSA. We performed multilevel linear modelling. We controlled for confounders, which were detected using a Directed Acyclic Graph. Result We included 497 participants from the CSHA and 9308 from the CLSA. The mean age was 78.0 in the CSHA and 72.0 in the CLSA, and male accounted for 36.4% in the CSHA and 50.2 in the CLSA. Mean MM was 2.1 in both cohorts, with a higher prevalence of MM in women (CSHA 63.9%; CLSA 64.2%) than in men (CSHA 55.8%; CLSA 59.5%). When comparing both cohorts, we found that baseline MM was not associated with changes in the Z‐scores for the ANT (CSHA: 0.16, CI95: ‐0.014 to 0.34; CLSA: ‐0.002, CI95: ‐0.044 to 0.04), RAVL delayed recall (CSHA ‐0.033, CI95: ‐0.23 to 0.16; CLSA: 0.031, IC95: ‐0.013 to 0.074), or DSST in CSHA (0.1, CI95: ‐0.084 to 0.29) / MAT in CLSA (0.008, CI95: ‐0.035 to 0.052). Conclusion We did not find differences in Z‐scores changes over 5 years follow up in the CSHA and 3 years follow up in the CLSA, for three neuropsychological tests among Canadians ≥65 years recruited over two decades apart.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
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  • 5
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S11 ( 2022-12)
    Abstract: The worldwide population ageing is a major driver for the increasing prevalence of multimorbidity, which is the co‐occurrence/ coexistence of multiple chronic conditions in the same individual. Simultaneously, cognitive decline has become a worldwide burden. Previous research has shown that there might be an association between multimorbidity as a risk for cognitive decline but no systematic review has evaluated this association. Objective To quantify the association between multimorbidity and cognitive decline through a systematic review, defining cognitive decline as a change in neuropsychological test scores or clinical diagnosis of mild cognitive impairment or dementia. Method We followed the PRISMA guidelines. We searched Medline/Pubmed, EMBASE, PsychINFO, CINAHL, LILACS, Scopus and ProQuest for studies published between January 1996 and May 2021. We evaluated study references for additional studies. We selected studies with a clear definition of multimorbidity, and cognitive decline, defined as cognitive impairment, dementia, or change in cognitive test scores. With one exception, all data were from high‐income countries and largely Caucasian populations. We employed the critical appraisal tools from the Joanna Briggs Institute to assess the risk of bias. We present a narrative data synthesis from each study in conjunction with key design information. PROSPERO register (CRD42020167253). Result We initially identified 1433 references, of which 16 studies fulfilled inclusion criteria, and were included; we found three additional studies through studies references. These studies encompassed a total of 90606 participants. Thirteen studies were cohorts, four cross‐sectional and two case‐control designs. Ten studies were population registers, five memory clinics cohorts, two population‐based surveys and one from administrative data. We found a high degree of heterogeneity among studies, driven by the use of multiple definitions of multimorbidity and cognitive decline that precluded a meta‐analysis. In general, all studies noticed an increased risk of cognitive decline or diminishing test scores with increasing accumulation of chronic disease. Future research will need to address a standardized definition of multimorbidity and cognitive decline/scores as well as obtain and evaluate data from low‐ and middle‐income countries. Conclusion We found an association between suffering multimorbidity and increasing risk of cognitive decline measured as cognitive test scores or diagnosis of MCI or dementia.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
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  • 6
    In: Brain Injury, Informa UK Limited, Vol. 21, No. 2 ( 2007-01), p. 107-112
    Type of Medium: Online Resource
    ISSN: 0269-9052 , 1362-301X
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2007
    detail.hit.zdb_id: 2004054-4
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  • 7
    Online Resource
    Online Resource
    Informa UK Limited ; 2003
    In:  Topics in Stroke Rehabilitation Vol. 10, No. 2 ( 2003-07), p. 77-106
    In: Topics in Stroke Rehabilitation, Informa UK Limited, Vol. 10, No. 2 ( 2003-07), p. 77-106
    Type of Medium: Online Resource
    ISSN: 1074-9357 , 1945-5119
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2003
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  • 8
    In: Epilepsia, Wiley, Vol. 56, No. 6 ( 2015-06), p. 864-872
    Abstract: To develop and validate a shortened version of the Quality of Life in Childhood Epilepsy Questionnaire ( QOLCE ). A secondary aim was to compare baseline risk factors predicting health‐related quality of life ( HRQoL ) in children newly diagnosed with epilepsy, as identified using the original and shortened version. Methods Data came from the Health‐Related Quality of Life in Children with Epilepsy Study ( HERQULES , N = 373), a multicenter prospective cohort study. Principal component analysis reduced the number of items from the original QOLCE , and factor analysis was used to assess the factor structure of the shortened version. Convergent and divergent validity was assessed by correlating the Child Health Questionnaire ( CHQ ) with the shortened QOLCE . Multiple regression identified risk factors at diagnosis for HRQoL at 24 months. Results A four‐factor, higher‐order, 55‐item solution was obtained. A total of 21 items were removed. The final model represents functioning in four dimensions of HRQoL : Cognitive, Emotional, Social, and Physical. The shortened QOLCE demonstrated acceptable fit: Bentler's Comparative Fit Index = 0.944; Tucker‐Lewis Index = 0.942; root mean square approximation = 0.058 (90% CI: 0.056–0.061); weighted root mean square residuals (WRMR) = 1.582, and excellent internal consistency (α = 0.96, subscales α  〉  0.80). Factor loadings were good (first‐order: λ = 0.66–0.93; higher‐order λ = 0.66–0.85; p  〈  0.001 for all). The shortened QOLCE scores correlated strongly with similar subscales of the Child Health Questionnaire (ρ = 0.38–0.70) while correlating weakly with dissimilar subscales (ρ = 0.30–0.31). While controlling for HRQoL at diagnosis, predictors for better HRQoL at 24 months were the following: no cognitive problems reported (p = 0.001), better family functioning (p = 0.014), fewer family demands (p = 0.008), with an interaction between baseline HRQoL and cognitive problems (p = 0.011). Significance Results offer initial evidence regarding reliability and validity of the proposed 55‐item shortened version of the QOLCE ( QOLCE ‐55). The QOLCE ‐55 produced results on risk factors consistent with those found using the original measure. Given the fewer items, QOLCE ‐55 may be a viable option reducing respondent burden when assessing HRQoL in children with epilepsy.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2002194-X
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  • 9
    Online Resource
    Online Resource
    Elsevier BV ; 2017
    In:  Autonomic Neuroscience Vol. 207 ( 2017-11), p. 28-36
    In: Autonomic Neuroscience, Elsevier BV, Vol. 207 ( 2017-11), p. 28-36
    Type of Medium: Online Resource
    ISSN: 1566-0702
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2020182-5
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2010
    In:  Quality of Life Research Vol. 19, No. 7 ( 2010-9), p. 955-964
    In: Quality of Life Research, Springer Science and Business Media LLC, Vol. 19, No. 7 ( 2010-9), p. 955-964
    Type of Medium: Online Resource
    ISSN: 0962-9343 , 1573-2649
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 2008960-0
    SSG: 5,1
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