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GAMER MRI: Gated-attention mechanism ranking of multi-contrast MRI in brain pathology

Lu, Po-Jui ; Yoo, Youngjin ; Rahmanzadeh, Reza ; [et al.]

Elsevier BV ; 2021

In: NeuroImage: Clinical Vol. 29 ( 2021), p. 102522-

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In: NeuroImage: Clinical, Elsevier BV, Vol. 29 ( 2021), p. 102522-

Type of Medium: Online Resource

ISSN: 2213-1582

URL: Article

DOI: 10.1016/j.nicl.2020.102522

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2701571-3

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A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis

Rahmanzadeh, Reza ; Galbusera, Riccardo ; Lu, Po‐Jui ; [et al.]

Wiley ; 2022

In: Annals of Neurology Vol. 92, No. 3 ( 2022-09), p. 486-502

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In: Annals of Neurology, Wiley, Vol. 92, No. 3 ( 2022-09), p. 486-502

Abstract: Neuropathological studies have shown that multiple sclerosis (MS) lesions are heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it remains a challenge to identify specific chronic lesion types, especially remyelinated lesions, in vivo in patients with MS. Methods We performed 3 studies: (1) a cross‐sectional study in a prospective cohort of 115 patients with MS and 76 healthy controls, who underwent 3 T magnetic resonance imaging (MRI) for quantitative susceptibility mapping (QSM), myelin water fraction (MWF), and neurite density index (NDI) maps. White matter (WM) lesions in QSM were classified into 5 QSM lesion types (iso‐intense, hypo‐intense, hyperintense, lesions with hypo‐intense rims, and lesions with paramagnetic rim legions [PRLs]); (2) a longitudinal study of 40 patients with MS to study the evolution of lesions over 2 years; (3) a postmortem histopathology‐QSM validation study in 3 brains of patients with MS to assess the accuracy of QSM classification to identify neuropathological lesion types in 63 WM lesions. Results At baseline, hypo‐ and isointense lesions showed higher mean MWF and NDI values compared to other QSM lesion types ( p 〈 0.0001). Further, at 2‐year follow‐up, hypo‐/iso‐intense lesions showed an increase in MWF. Postmortem analyses revealed that QSM highly accurately identifies (1) fully remyelinated areas as hypo‐/iso‐intense (sensitivity = 88.89% and specificity = 100%), (2) chronic inactive lesions as hyperintense (sensitivity = 71.43% and specificity = 92.00%), and (3) chronic active/smoldering lesions as PRLs (sensitivity = 92.86% and specificity = 86.36%). Interpretation These results provide the first evidence that it is possible to distinguish chronic MS lesions in a clinical setting, hereby supporting with new biomarkers to develop and assess remyelinating treatments. ANN NEUROL 2022;92:486–502

Type of Medium: Online Resource

ISSN: 0364-5134 , 1531-8249

URL: Issue

URL: Article

DOI: 10.1002/ana.v92.3

DOI: 10.1002/ana.26441

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2037912-2

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BOLD New Directions in Myocardial Ischemia Imaging–Myocardial Oxygenation Assessment by Cardiac Magnetic Resonance

Weinsaft, Jonathan W. ; Spincemaille, Pascal

Elsevier BV ; 2012

In: Journal of the American College of Cardiology Vol. 59, No. 22 ( 2012-05), p. 1965-1967

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In: Journal of the American College of Cardiology, Elsevier BV, Vol. 59, No. 22 ( 2012-05), p. 1965-1967

Type of Medium: Online Resource

ISSN: 0735-1097

URL: Article

DOI: 10.1016/j.jacc.2012.01.056

RVK:

XA 17760

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1468327-1

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Anticipatory Posturing of the Vocal Tract Reveals Dissociation of Speech Movement Plans from Linguistic Units

Tilsen, Sam ; Spincemaille, Pascal ; Xu, Bo ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS ONE Vol. 11, No. 1 ( 2016-1-13), p. e0146813-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 1 ( 2016-1-13), p. e0146813-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0146813

DOI: 10.1371/journal.pone.0146813.g001

DOI: 10.1371/journal.pone.0146813.g002

DOI: 10.1371/journal.pone.0146813.g003

DOI: 10.1371/journal.pone.0146813.g004

DOI: 10.1371/journal.pone.0146813.g005

DOI: 10.1371/journal.pone.0146813.g006

DOI: 10.1371/journal.pone.0146813.g007

DOI: 10.1371/journal.pone.0146813.t001

DOI: 10.1371/journal.pone.0146813.s001

DOI: 10.1371/journal.pone.0146813.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2267670-3

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QSM Throughout the Body

Dimov, Alexey V. ; Li, Jiahao ; Nguyen, Thanh D. ; [et al.]

Wiley ; 2023

In: Journal of Magnetic Resonance Imaging Vol. 57, No. 6 ( 2023-06), p. 1621-1640

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In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 57, No. 6 ( 2023-06), p. 1621-1640

Abstract: Magnetic materials in tissue, such as iron, calcium, or collagen, can be studied using quantitative susceptibility mapping (QSM). To date, QSM has been overwhelmingly applied in the brain, but is increasingly utilized outside the brain. QSM relies on the effect of tissue magnetic susceptibility sources on the MR signal phase obtained with gradient echo sequence. However, in the body, the chemical shift of fat present within the region of interest contributes to the MR signal phase as well. Therefore, correcting for the chemical shift effect by means of water‐fat separation is essential for body QSM. By employing techniques to compensate for cardiac and respiratory motion artifacts, body QSM has been applied to study liver iron and fibrosis, heart chamber blood and placenta oxygenation, myocardial hemorrhage, atherosclerotic plaque, cartilage, bone, prostate, breast calcification, and kidney stone.

Type of Medium: Online Resource

ISSN: 1053-1807 , 1522-2586

URL: Issue

URL: Article

DOI: 10.1002/jmri.v57.6

DOI: 10.1002/jmri.28624

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 1497154-9

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Respiratory and cardiac self‐gated free‐breathing cardiac CINE imaging with multiecho 3D hybrid radial SSFP acquisition

Liu, Jing ; Spincemaille, Pascal ; Codella, Noel C. F. ; [et al.]

Wiley ; 2010

In: Magnetic Resonance in Medicine Vol. 63, No. 5 ( 2010-05), p. 1230-1237

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In: Magnetic Resonance in Medicine, Wiley, Vol. 63, No. 5 ( 2010-05), p. 1230-1237

Abstract: A respiratory and cardiac self‐gated free‐breathing three‐dimensional cine steady‐state free precession imaging method using multiecho hybrid radial sampling is presented. Cartesian mapping of the k ‐space center along the slice encoding direction provides intensity‐weighted position information, from which both respiratory and cardiac motions are derived. With in plan radial sampling acquired at every pulse repetition time, no extra scan time is required for sampling the k ‐space center. Temporal filtering based on density compensation is used for radial reconstruction to achieve high signal‐to‐noise ratio and contrast‐to‐noise ratio. High correlation between the self‐gating signals and external gating signals is demonstrated. This respiratory and cardiac self‐gated, free‐breathing, three‐dimensional, radial cardiac cine imaging technique provides image quality comparable to that acquired with the multiple breath‐hold two‐dimensional Cartesian steady‐state free precession technique in short‐axis, four‐chamber, and two‐chamber orientations. Functional measurements from the three‐dimensional cardiac short axis cine images are found to be comparable to those obtained using the standard two‐dimensional technique. Magn Reson Med 63:1230–1237, 2010. © 2010 Wiley‐Liss, Inc.

Type of Medium: Online Resource

ISSN: 0740-3194 , 1522-2594

URL: Issue

URL: Article

DOI: 10.1002/mrm.v63:5

DOI: 10.1002/mrm.22306

Language: English

Publisher: Wiley

Publication Date: 2010

detail.hit.zdb_id: 1493786-4

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Morphology enabled dipole inversion (MEDI) from a single‐angle acquisition: Comparison with COSMOS in human brain imaging

Liu, Tian ; Liu, Jing ; de Rochefort, Ludovic ; [et al.]

Wiley ; 2011

In: Magnetic Resonance in Medicine Vol. 66, No. 3 ( 2011-09), p. 777-783

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In: Magnetic Resonance in Medicine, Wiley, Vol. 66, No. 3 ( 2011-09), p. 777-783

Abstract: Magnetic susceptibility varies among brain structures and provides insights into the chemical and molecular composition of brain tissues. However, the determination of an arbitrary susceptibility distribution from the measured MR signal phase is a challenging, ill‐conditioned inverse problem. Although a previous method named calculation of susceptibility through multiple orientation sampling (COSMOS) has solved this inverse problem both theoretically and experimentally using multiple angle acquisitions, it is often impractical to carry out on human subjects. Recently, the feasibility of calculating the brain susceptibility distribution from a single‐angle acquisition was demonstrated using morphology enabled dipole inversion (MEDI). In this study, we further improved the original MEDI method by sparsifying the edges in the quantitative susceptibility map that do not have a corresponding edge in the magnitude image. Quantitative susceptibility maps generated by the improved MEDI were compared qualitatively and quantitatively with those generated by calculation of susceptibility through multiple orientation sampling. The results show a high degree of agreement between MEDI and calculation of susceptibility through multiple orientation sampling, and the practicality of MEDI allows many potential clinical applications. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.

Type of Medium: Online Resource

ISSN: 0740-3194 , 1522-2594

URL: Issue

URL: Article

DOI: 10.1002/mrm.v66.3

DOI: 10.1002/mrm.22816

Language: English

Publisher: Wiley

Publication Date: 2011

detail.hit.zdb_id: 1493786-4

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Bone quantitative susceptibility mapping using a chemical species–specific signal model with ultrashort and conventional echo data

Dimov, Alexey V. ; Liu, Zhe ; Spincemaille, Pascal ; [et al.]

Wiley ; 2018

In: Magnetic Resonance in Medicine Vol. 79, No. 1 ( 2018-01), p. 121-128

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In: Magnetic Resonance in Medicine, Wiley, Vol. 79, No. 1 ( 2018-01), p. 121-128

Abstract: To develop quantitative susceptibility mapping (QSM) of bone using an ultrashort echo time (UTE) gradient echo (GRE) sequence for signal acquisition and a bone‐specific effective transverse relaxation rate ( ) to model water–fat MR signals for field mapping. Methods Three‐dimensional radial UTE data (echo times ≥ 40 μs) was acquired on a 3 Tesla scanner and fitted with a bone‐specific signal model to map the chemical species and susceptibility field. Experiments were performed ex vivo on a porcine hoof and in vivo on healthy human subjects (n = 7). For water–fat separation, a bone‐specific model assigning decay mostly to water was compared with the standard models that assigned the same decay for both fat and water. In the ex vivo experiment, bone QSM was correlated with CT. Results Compared with standard models, the bone‐specific method significantly reduced errors in the fat fraction within the cortical bone in all tested data sets, leading to reduced artifacts in QSM. Good correlation was found between bone CT and QSM values in the porcine hoof (R 2 = 0.77). Bone QSM was successfully generated in all subjects. Conclusions The QSM of bone is feasible using UTE with a conventional echo time GRE acquisition and a bone‐specific signal model. Magn Reson Med 79:121–128, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Type of Medium: Online Resource

ISSN: 0740-3194 , 1522-2594

URL: Issue

URL: Article

DOI: 10.1002/mrm.v79.1

DOI: 10.1002/mrm.26648

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 1493786-4

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Subsecond accurate myelin water fraction reconstruction from FAST‐T 2 data with 3D UNET

Kim, Jeremy ; Nguyen, Thanh D. ; Zhang, Jinwei ; [et al.]

Wiley ; 2022

In: Magnetic Resonance in Medicine Vol. 87, No. 6 ( 2022-06), p. 2979-2988

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In: Magnetic Resonance in Medicine, Wiley, Vol. 87, No. 6 ( 2022-06), p. 2979-2988

Abstract: To develop a 3D UNET convolutional neural network for rapid extraction of myelin water fraction (MWF) maps from six‐echo fast acquisition with spiral trajectory and T 2 ‐prep data and to evaluate its accuracy in comparison with multilayer perceptron (MLP) network. Methods The MWF maps were extracted from 138 patients with multiple sclerosis using an iterative three‐pool nonlinear least‐squares algorithm (NLLS) without and with spatial regularization (srNLLS), which were used as ground‐truth labels to train, validate, and test UNET and MLP networks as a means to accelerate data fitting. Network testing was performed in 63 patients with multiple sclerosis and a numerically simulated brain phantom at SNR of 200, 100 and 50. Results Simulations showed that UNET reduced the MWF mean absolute error by 30.1% to 56.4% and 16.8% to 53.6% over the whole brain and by 41.2% to 54.4% and 21.4% to 49.4% over the lesions for predicting srNLLS and NLLS MWF, respectively, compared to MLP, with better performance at lower SNRs. UNET also outperformed MLP for predicting srNLLS MWF in the in vivo multiple‐sclerosis brain data, reducing mean absolute error over the whole brain by 61.9% and over the lesions by 67.5%. However, MLP yielded 41.1% and 51.7% lower mean absolute error for predicting in vivo NLLS MWF over the whole brain and the lesions, respectively, compared with UNET. The whole‐brain MWF processing time using a GPU was 0.64 seconds for UNET and 0.74 seconds for MLP. Conclusion Subsecond whole‐brain MWF extraction from fast acquisition with spiral trajectory and T 2 ‐prep data using UNET is feasible and provides better accuracy than MLP for predicting MWF output of srNLLS algorithm.

Type of Medium: Online Resource

ISSN: 0740-3194 , 1522-2594

URL: Issue

URL: Article

DOI: 10.1002/mrm.v87.6

DOI: 10.1002/mrm.29176

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 1493786-4

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Kalman filtering for real-time navigator processing

Spincemaille, Pascal ; Nguyen, Thanh D. ; Prince, Martin R. ; [et al.]

Wiley ; 2008

In: Magnetic Resonance in Medicine Vol. 60, No. 1 ( 2008-07), p. 158-168

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In: Magnetic Resonance in Medicine, Wiley, Vol. 60, No. 1 ( 2008-07), p. 158-168

Type of Medium: Online Resource

ISSN: 0740-3194 , 1522-2594

URL: Issue

URL: Article

DOI: 10.1002/mrm.v60:1

DOI: 10.1002/mrm.21649

Language: English

Publisher: Wiley

Publication Date: 2008

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