In:
European Journal of Neuroscience, Wiley, Vol. 41, No. 9 ( 2015-05), p. 1219-1226
Kurzfassung:
High‐frequency deep brain stimulation ( HFS ‐ DBS ) of the subcallosal cingulate ( SCC ) region has been investigated as a treatment for refractory forms of depression with a ~50% remission rate in open label studies. However, the therapeutic mechanisms of DBS are still largely unknown. Using anaesthetized S prague D awley rats, we recorded neuronal spiking activity in 102 neurons of the dorsal raphe ( DR ) before, during and after the induction of a 5‐min HFS train in the infralimbic region ( IL ) of the medial prefrontal cortex ( mPFC ), the rodent homologue of the human SCC . The majority of DR cells (82%) significantly decreased firing rate during HFS ( P 〈 0.01, 55.7 ± 4.5% of baseline, 35 rats). To assess whether mPFC ‐ HFS mediates inhibition of DR cellular firing by stimulating local GABA ergic interneurons, the GABA A antagonist bicuculline ( B ic, 100 μ m ) was injected directly into the DR during HFS . Neurons inhibited by HFS recovered their firing rate during B ic+ HFS ( P 〈 0.01, n = 15, seven rats) to levels not different from baseline. Cells that were not affected by HFS did not change firing rate during B ic+ HFS ( P = 0.968, n = 7, three rats). These results indicate that blocking GABA A reverses HFS ‐mediated inhibition of DR neurons. As the cells that were not inhibited by HFS were also unaffected by HFS + B ic, they are probably not innervated by local GABA . Taken together, our results suggest that mPFC ‐ HFS may exert a preferential effect on DR neurons with GABA A receptors.
Materialart:
Online-Ressource
ISSN:
0953-816X
,
1460-9568
DOI:
10.1111/ejn.2015.41.issue-9
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
2005178-5
SSG:
12
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