In:
Medical review, National Library of Serbia, Vol. 74, No. 5-6 ( 2021), p. 183-186
Abstract:
Introduction. Tubulointerstitial nephritis and uveitis syndrome is a rare
oculo-renal disease characterized by the presence of bilateral, anterior
uveitis and tubulointerstitial nephritis. The pathogenesis of this disease
is still not completely clear. It is associated with prior drug use,
infections and autoimmune diseases. The involvement of the cellular and
humoral immune responses and genetic predisposition to the development of
this syndrome are frequently mentioned in the literature. In a certain
number of cases, despite extensive diagnostics, the cause remains unknown
(idiopathic tubulointerstitial nephritis and uveitis syndrome). Case Report.
A fifteen-year-old female patient was admitted to the Department of
Nephrology due to complaints of headache in the temples that occasionally
occurred in the previous months. Three days before admission, the patient
presented with symptoms of upper respiratory tract infection and subfebrile
temperature (to 37.8o C). Laboratory test results revealed the development
of acute tubulointerstitial nephritis, and in the fifth week of the disease,
bilateral anterior uveitis was detected. The diagnosis was confirmed by
percutaneous kidney biopsy. Systemic and local corticosteroid therapy was
introduced, and after a month it resulted in gradual normalization of kidney
function, proteinuria reduction and withdrawal of the ophthalmic symptoms.
Conclusion. Due to the fact that kidney damage is often self-limited and
that uveitis tends to be recurrent, there is a high probability of untimely
diagnosis. Early recognition, detection of potential causes and initiation
of treatment, are crucial in the prevention of disease progression and
development of chronic sequelae such as chronic renal failure and chronic
uveitis.
Type of Medium:
Online Resource
ISSN:
0025-8105
,
1820-7383
DOI:
10.2298/MPNS2106183K
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2021
detail.hit.zdb_id:
2381028-2
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