In:
American Journal of Rhinology & Allergy, SAGE Publications, Vol. 28, No. 1 ( 2014-01), p. 20-22
Abstract:
Nasal polyposis is a chronic inflammation of nasal and paranasal sinuses in the pathogenesis of which adhesion molecules may have a significant role. This study investigates the possible role of certain adhesion molecules, mucins, and oncogenes in nasal polyposis recurrence. Methods A sample study of 21 individuals (17 men and 4 women) aged 47.44 ± 15.10 years with nasal polyposis who had undergone nasal surgery twice was used. Twenty-one individuals aged 46.9 ± 12.8 years suffering from nasal polyposis who had undergone surgery only once in the same period were used as a control sample. Results Statistically significant differences between the two groups were observed regarding epithelial membrane antigen (EMA/mucin 1) of stromal cells (p 〈 0.001) and CD86 stromal expression (p = 0.009). No patient of the control group exhibited high (++) D86 stromal expression, whereas six patients of the resurgery group did so. When EMA and CD86 were included in a logistic regression model, stromal EMA was found to be positively related to recurrence. Conclusion Adhesion molecules may relate to nasal polyp prognosis and recurrence rates.
Type of Medium:
Online Resource
ISSN:
1945-8924
,
1945-8932
DOI:
10.2500/ajra.2014.28.3962
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2554548-6
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