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von Reichenau, Charlotte ; Bilimovič, Alexander ; Wagenführ, Rolf ; [et al.]

Springer Science and Business Media LLC ; 1943

In: Zeitschrift für Nationalökonomie Vol. 10, No. 3-4 ( 1943-8), p. 511-559

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In: Zeitschrift für Nationalökonomie, Springer Science and Business Media LLC, Vol. 10, No. 3-4 ( 1943-8), p. 511-559

Type of Medium: Online Resource

ISSN: 0044-3158

URL: Article

DOI: 10.1007/BF02329111

Language: German

Publisher: Springer Science and Business Media LLC

Publication Date: 1943

detail.hit.zdb_id: 635037-9

detail.hit.zdb_id: 120628-X

detail.hit.zdb_id: 1476543-3

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ID: 178

Maerz, Jan ; Steimle, Alexander ; Grohnbach, Kerstin ; [et al.]

Elsevier BV ; 2015

In: Cytokine Vol. 76, No. 1 ( 2015-11), p. 97-

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In: Cytokine, Elsevier BV, Vol. 76, No. 1 ( 2015-11), p. 97-

Type of Medium: Online Resource

ISSN: 1043-4666

URL: Article

DOI: 10.1016/j.cyto.2015.08.188

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 1463198-2

SSG: 12

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Abstract 541: A Hedgehog-signaling Dependent Gene Regulatory Network Directly Delays Second Heart Field Differentiation to Prevent Congenital Heart Disease

Rowton, Megan ; Rydeen, Ariel ; Carlos, Perez-Cervantes ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2020

In: Circulation Research Vol. 127, No. Suppl_1 ( 2020-07-31)

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In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 127, No. Suppl_1 ( 2020-07-31)

Abstract: The first heart field (FHF) and the second heart field (SHF) comprise the major progenitor pools for the developing vertebrate heart. We investigated the delayed differentiation of the SHF relative to the FHF, a major distinguishing feature of these fields. Single-cell transcriptional profiling of the SHF revealed a differentiation trajectory of SHF progenitors to cardiomyocytes. Hedgehog (Hh) signaling was highly enriched in the progenitor state in signaling pathway analysis, suggesting a possible role in cardiomyocyte differentiation control. Transcriptional profiling of the SHF following removal of active Hh signaling in vivo revealed inappropriate cardiomyocyte gene expression. We observed precocious cardiomyocyte differentiation in the SHF in vivo in Hh mutants, which led to Congenital Heart Disease (CHD). Modeling active Hh signaling in a novel mouse embryonic stem cell (mESC) line through transient expression of the activating Hh transcription factor (TF), GLI1, in cardiac progenitors delayed the onset of cardiomyocyte differentiation. GLI1 directly activated a progenitor-specific gene regulatory network, dominated by repressive TFs, that prevented the acquisition of the cardiomyocyte gene regulatory network. Maintained expression of one GLI1 target TF, FOXF1, repressed the cardiomyocyte differentiation program. FOXF1 binding sites were identified at putative regulatory elements near repressed cardiac genes involved in contraction, electrical impulse propagation and transcriptional regulation. Finally, FOXF1 repressed the activity of these elements in vitro , indicating that FOXF1 can directly repress the activation of genes essential for cardiomyocyte differentiation. Together, these results indicate that a Hh-dependent gene regulatory network including transcriptional repressors directly delays the onset of cardiomyocyte gene expression to delay SHF differentiation. Abrogation of Hh signaling and the resultant premature differentiation of cardiac progenitors provides a molecular mechanism for the ontogeny of some CHD.

Type of Medium: Online Resource

ISSN: 0009-7330 , 1524-4571

URL: Article

DOI: 10.1161/res.127.suppl_1.541

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2020

detail.hit.zdb_id: 1467838-X

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3D Micro‐Printing: A new Era for Med‐Tech Applications : How three‐dimensional thinking is turning a piece of material into smart medical devices

Steimle, Alexander

Wiley ; 2018

In: Laser Technik Journal Vol. 15, No. 1 ( 2018-01), p. 32-34

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In: Laser Technik Journal, Wiley, Vol. 15, No. 1 ( 2018-01), p. 32-34

Abstract: In recent years, 3D printing has attracted increasing attention in many industries. From bioprinting of living organs to engine and airplane components, a variety of 3D printing techniques are already in use today, mainly differentiated by the additive or sub‐tractive manufacturing approach. But what's the application potentiality in the med‐tech industry with regards to 3D printing at micro‐scale? And how innovative three‐dimensional thinking can tackle human diseases such as the retinal vein occlusion (RVO) and create transformative products?

Type of Medium: Online Resource

ISSN: 1613-7728 , 1863-9119

URL: Issue

URL: Article

DOI: 10.1002/latj.v15.1

DOI: 10.1002/latj.201800003

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 2410715-3

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Proteome and phosphoproteome analysis of commensally induced dendritic cell maturation states

Korkmaz, Ali Giray ; Popov, Todor ; Peisl, Loulou ; [et al.]

Elsevier BV ; 2018

In: Journal of Proteomics Vol. 180 ( 2018-05), p. 11-24

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In: Journal of Proteomics, Elsevier BV, Vol. 180 ( 2018-05), p. 11-24

Type of Medium: Online Resource

ISSN: 1874-3919

URL: Article

DOI: 10.1016/j.jprot.2017.11.008

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2400835-7

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Therapierefraktäre erythematöse Schwellung des Ohres

Seiringer, Peter ; Lammer, Judith ; Steimle‐Grauer, Annette ; [et al.]

Wiley ; 2022

In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft Vol. 20, No. 9 ( 2022-09), p. 1239-1242

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In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Wiley, Vol. 20, No. 9 ( 2022-09), p. 1239-1242

Type of Medium: Online Resource

ISSN: 1610-0379 , 1610-0387

URL: Issue

URL: Article

DOI: 10.1111/ddg.v20.9

DOI: 10.1111/ddg.14811_g

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2099463-1

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Acute generalized pustular psoriasis successfully treated with the IL‐23p19 antibody risankizumab

Heyer, Sarah ; Seiringer, Peter ; Eyerich, Stefanie ; [et al.]

Wiley ; 2022

In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft Vol. 20, No. 10 ( 2022-10), p. 1362-1364

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In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Wiley, Vol. 20, No. 10 ( 2022-10), p. 1362-1364

Type of Medium: Online Resource

ISSN: 1610-0379 , 1610-0387

URL: Issue

URL: Article

DOI: 10.1111/ddg.v20.10

DOI: 10.1111/ddg.14857

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2099463-1

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Low dose dietary contamination with deoxynivalenol mycotoxin exacerbates enteritis and colorectal cancer in mice

Djouina, Madjid ; Waxin, Christophe ; Caboche, Ségolène ; [et al.]

Elsevier BV ; 2023

In: Science of The Total Environment Vol. 900 ( 2023-11), p. 165722-

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In: Science of The Total Environment, Elsevier BV, Vol. 900 ( 2023-11), p. 165722-

Type of Medium: Online Resource

ISSN: 0048-9697

URL: Article

DOI: 10.1016/j.scitotenv.2023.165722

RVK:

AR 10100

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 1498726-0

detail.hit.zdb_id: 121506-1

SSG: 12

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Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains

Steimle, Alex ; Menz, Sarah ; Bender, Annika ; [et al.]

Public Library of Science (PLoS) ; 2019

In: PLOS Biology Vol. 17, No. 6 ( 2019-6-17), p. e3000334-

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In: PLOS Biology, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2019-6-17), p. e3000334-

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.3000334

DOI: 10.1371/journal.pbio.3000334.g001

DOI: 10.1371/journal.pbio.3000334.g002

DOI: 10.1371/journal.pbio.3000334.g003

DOI: 10.1371/journal.pbio.3000334.g004

DOI: 10.1371/journal.pbio.3000334.g005

DOI: 10.1371/journal.pbio.3000334.g006

DOI: 10.1371/journal.pbio.3000334.s001

DOI: 10.1371/journal.pbio.3000334.s002

DOI: 10.1371/journal.pbio.3000334.s003

DOI: 10.1371/journal.pbio.3000334.s004

DOI: 10.1371/journal.pbio.3000334.s005

DOI: 10.1371/journal.pbio.3000334.s006

DOI: 10.1371/journal.pbio.3000334.s007

DOI: 10.1371/journal.pbio.3000334.s008

DOI: 10.1371/journal.pbio.3000334.s009

DOI: 10.1371/journal.pbio.3000334.s010

DOI: 10.1371/journal.pbio.3000334.s011

DOI: 10.1371/journal.pbio.3000334.s012

DOI: 10.1371/journal.pbio.3000334.s013

DOI: 10.1371/journal.pbio.3000334.s014

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2019

detail.hit.zdb_id: 2126773-X

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Zeeman-Sisyphus deceleration for heavy molecules with perturbed excited-state structure

Sawaoka, Hiromitsu ; Frenett, Alexander ; Nasir, Abdullah ; [et al.]

American Physical Society (APS) ; 2023

In: Physical Review A Vol. 107, No. 2 ( 2023-2-15)

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In: Physical Review A, American Physical Society (APS), Vol. 107, No. 2 ( 2023-2-15)

Type of Medium: Online Resource

ISSN: 2469-9926 , 2469-9934

URL: Article

DOI: 10.1103/PhysRevA.107.022810

RVK:

UA 6500.3A

Language: English

Publisher: American Physical Society (APS)

Publication Date: 2023

detail.hit.zdb_id: 2844156-4

detail.hit.zdb_id: 209769-2

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