In:
Science Signaling, American Association for the Advancement of Science (AAAS), Vol. 16, No. 779 ( 2023-04-04)
Abstract:
GPR183 is a GPCR for oxysterol ligands, including 7α,25-OHC, and mediates the migration of various immune cells and their proper positioning in lymphoid tissues. In addition to its involvement in physio-logical processes, such as insulin secretion and antibody responses, GPR183 is also associated with cancers and neurodegenerative and inflammatory diseases, making it an important therapeutic target. Kjær et al. characterized the signaling and regulation of GPR183 function in cells in response to various ligands. Unlike many other chemotactic GPCRs, GPR183 internalization was β-arrestin–independent. Moreover, GPR183 interacted with caveolae rather than clathrin for ligand-induced internalization and required β-arrestin for 7α;,25-OHC–dependent chemotaxis. Together, these findings will aid in develop-ing ligands that can target specific effects of GPR183 activity in different settings. --JFF
Type of Medium:
Online Resource
ISSN:
1945-0877
,
1937-9145
DOI:
10.1126/scisignal.abl4283
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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