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  • 1
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    Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas
    Wiley ; 2014
    In:  Hemodialysis International Vol. 18, No. 3 ( 2014-07), p. 680-685
    Details
    In: Hemodialysis International, Wiley, Vol. 18, No. 3 ( 2014-07), p. 680-685
    Abstract: Myeloperoxidase is a proinflammatory protein that appears as a result of increased oxidative stress. It plays an important role in the promotion and progression of atherosclerosis. The aim of this study was to determine the importance of MPO as a predictive parameter for thrombosis of arteriovenous fistula ( AVF ). The study involved monitoring patients with AVFs for hemodialysis over a period of 2 years. There were 41 patients, 19 (46%) men and 22 (54%) women, with mean age of 65 ± 12.7 years. Routine laboratory analyses were carried out in all respondents, including determination of MPO concentration. Gender, demographic and anthropometrical characteristics, smoking, alcohol consumption, as well as the presence of diabetic nephropathy, as an etiological factor of kidney disease, were recorded. The group of patients who developed initial thrombosis of the AVF s had significantly different values for leukocytes (8.5 ± 3.8 vs. 7.3 ± 2.1, P = 0.024), erythrocytes (2.8 ± 0.27 vs. 3.2 ± 0.65; P = 0.019), hemoglobin (88.5 ± 81 vs. 99.1 ± 6.02; P = 0.041), and myeloperoxidase (19.3 ± 4.67 vs. 11.1 ± 4.43; P = 0.007) when compared with the group without fistula thrombosis. Diabetic nephropathy (P = 0.02) characterized the group of patients with thrombosis of the fistula. Diabetic nephropathy (B = 2.53, P = 0.049) and MPO (B = 0.03, P = 0.029) were statistically significant predictors of fistula thrombosis. In our study, MPO and diabetic nephropathy were predictors of thrombosis of the AVF .
    Type of Medium: Online Resource
    ISSN: 1492-7535 , 1542-4758
    URL: Issue
    URL: Article
    DOI: 10.1111/hdi.2014.18.issue-3
    DOI: 10.1111/hdi.12155
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2103570-2
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  • 2
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    Impact of Metabolic Syndrome and Malnutrition on Mortality in Chronic Hemodialysis Patients
    Elsevier BV ; 2010
    In:  Journal of Renal Nutrition Vol. 20, No. 1 ( 2010-1), p. 38-43
    Details
    In: Journal of Renal Nutrition, Elsevier BV, Vol. 20, No. 1 ( 2010-1), p. 38-43
    Type of Medium: Online Resource
    ISSN: 1051-2276
    URL: Article
    DOI: 10.1053/j.jrn.2009.01.021
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
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  • 3
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    Correlation of Mortality and Location of Arteriovenous Fistula in Hemodialysis Patients
    SAGE Publications ; 2011
    In:  The International Journal of Artificial Organs Vol. 34, No. 1 ( 2011-01), p. 26-33
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 34, No. 1 ( 2011-01), p. 26-33
    Abstract: Since the type of vascular access is very important and a significant risk factor for mortality in patients on hemodialysis, the aim of our study was to determine the impact of AVF positioning on the mortality of our patients. Methods The survey was organized as a prospective, clinical and non-randomized study of 538 surgical interventions on 323 patients, which indicates that a large number of patients had more than one fistula. Among these patients, 120 subjects (81 (67.5%) men and 39 (32.5%) women) died during the study period. We analyzed the demographic structure, the site location and type of anastomosis for the arteriovenous fistula, artery and vein lumen and presence of instillation catheters, as well as measuring flow through the fistula and arterial blood pressure. Biochemical parameters thought to have a significant impact on survival were obtained from routine monthly analyses. Results In patients in whom infection was the cause of death, termino-terminal anastomosis was more frequently present (p=0.035). Variables that were statistically significant predictors of death were elderly individuals (Beta 0.033, p 〈 0.001); patients whose diastolic blood pressure was low (Beta –0.028, p 〈 0.001); and the position of the arteriovenous fistula (distal Beta –0.737, p=0.001; proximal Beta –0.581, p=0.008). Patients with a cubital fistula (p=0.001) had a significantly shorter Kaplan-Meier survival curve. Conclusions End-to-end artery and vein connection was a significantly more common form of anastomosis in patients who died as a result of infection. Important parameters of mortality in our study were the position of the arteriovenous fistula, age, and the diastolic component of arterial blood pressure.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.5301/IJAO.2011.6311
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 1474999-3
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  • 4
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    Central venous catheters in hemodialysis: To accept recommendations or to stick to own experience
    National Library of Serbia ; 2008
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 65, No. 1 ( 2008), p. 21-26
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 65, No. 1 ( 2008), p. 21-26
    Abstract: Uvod/Cilj. Hemodijalizni kateteri integralni su deo hemodijalize, a najcesce komplikacije koje prate njihovo plasiranje i upotrebu su infekcija i tromboza. Cilj rada bio je analiza prevalencije komplikacija razlicito pozicioniranih centralnih venskih katetera za hemodijalizu. Metode. Studijom su obuhvaceni bolesnici cije lecenje je zahtevalo aktivnu depuraciju hemodijalizama, hospitalizovani u Klinickom centru u Kragujevcu od decembra 2003. do novembra 2006. godine. Predmet istrazivanja bila su 464 centralnih venskih katetera plasirana u navedenom periodu, a evidentirane su sve komplikacije koje su pratile njihovo plasiranje i upotrebu. Rezultati. Najvise katetera bilo je i plasirano u venu femoralis ? 86,8% katetera, a njihovo prosecno vreme funkcionisanja iznosilo je 17 kateter dana. U jugularnu venu plasirano je 9,2% katetera, sa prosecnim vremenom funkcionisanja od 17,3 dana, a u venu supklaviju 42% katetera sa prosecnim vremenom funkcionisanja od 25,9 dana. Utvrdjena je statisticki znacajna razlika (p = 0,03) u odnosu na duzinu funkcionisanja katetera. Mikrobioloskim ispitivanjem ? zasejavanjem kulture briseva koze ulaznog mesta katetera, dobijen je pozitivan nalaz kod 5,5% plasiranih katetera u femoralnu venu i kod 7,1% instiliranih katetera u jugularnu venu, bez statisticki znacajne razlike (p = 0,51). Hemokultura kod sumnje na bakteriemiju bila je pozitivna kod 3,7% bolesnika sa femoralnim i kod 4,8% sa jugularnim kateterima, bez statisticki znacajne razlike (p = 0,65). Zasejavanjem briseva sa vrhova odstranjenih katetera dobijen je pozitivan nalaz sa 8,9% femoralnih i 4,7% jugularnih katetera; statisticki znacajna razlika izmedju ispitivanih grupa nije postojala (p = 0,82). Kod 77,9% femoralnih, 71,4% jugularnih i 68,4% subklavija katetera nije bilo komplikacija koje prate plasiranje i manipulaciju katetera za hemodijalizu, a razlika je bila na granici statisticke znacajnosti (p = 0,06). Zakljucak. Nedovoljno ubedljiva stopa infekcije i manji procenat ozbiljnih komplikacija koje prate plasiranje i upotrebu centralnih venskih katetera plasiranih u femoralnu venu upucuje na to da je sopstveno iskustvo dovoljna preporuka koja potvrdjuje da femoralna vena ne predstavlja regiju sa povecanim rizikom za plasiranje katetera za hemodijalizu.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP0801021S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2008
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 5
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    The influence of Helicobacter pylori infection on the occurrence of gastroesophageal reflux in patients with renal insufficiency
    National Library of Serbia ; 2007
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 64, No. 12 ( 2007), p. 819-822
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 64, No. 12 ( 2007), p. 819-822
    Abstract: Uvod/Cilj. Pojacano lucenje zeludacne kiseline predstavlja kljucni patofizioloski mehanizam nastanka gastroezofagusne refluksne bolesti. Verovatan mehanizam kojim Helicobacter pylori infekcija ima protektivni efekat na pojavu gastroezofagusne refluksne bolesti jeste sklonost za nastanak atroficnog gastritisa kod inficiranih bakterijom Helicobacter pylori. Cilj rada bio je da se utvrdi uticaj Helicobacter pylori infekcije na pojavu gastroezofagusne refluksne bolesti kod bolesnika sa razlicitim fazama bubrezne insuficijencije. Metode. Istrazivanje je organizovano kao prospektivna, klinicka studija koja je obuhvatila 68 ispitanika, i to 33 bolesnika sa preterminalnom i 35 bolesnika sa terminalnom bubreznom slaboscu. Zbog dispeptickih tegoba svim ispitanicima uradjena je gornja ezofagogastroskopija, a Helicobacter pylori infekcija utvrdjena je ureaza testom. Rezultati. Bolesnici sa preterminalnom bubreznom insuficijencijom bili su znacajno mladji od bolesnika sa terminalnom bubreznom slaboscu (53,4?11,1 vs. 65,4?12,3 god.; p = 0,014). Izmedju dve grupe ispitanika nadjena je statisticki znacajna razlika u odnosu na Helicobacter pylori infekciju (p = 0,03), hijatusnu herniju (p = 0,008), gastroezofagusnu refluksnu bolest (p = 0,007) i ulkusnu bolest duodenuma (p = 0,002). Multiplom neparametarskom korelacionom analizom pronadjena je negativna korelacija izmedju Helicobacter pylori infekcije i gastroezofagusne refluksne bolesti (Kendal ?B = -0,523; p = 0,003) i hijatusne hernije (Kendal ?B = - 0,403; p = 0,021), dok je pozitivna korelacija dobijena izmedju gastroezofagusne refluksne bolesti i hijatusne hernije (Kendal ?B = 0,350; p = 0,044). Zakljucak. Helicobacter pylori infekcija je znacajan protektivni parametar za pojavu gastroezofagusne refluksne bolesti i kod bolesnika sa preterminalnom, kao i onih sa terminalnom bubreznom insuficijencijom.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP0712819S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2007
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 6
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    Frequency and characteristics of metabolic disorders in patients on haemodialysis
    National Library of Serbia ; 2008
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 65, No. 3 ( 2008), p. 205-209
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 65, No. 3 ( 2008), p. 205-209
    Abstract: Uvod/Cilj. Metabolicki sindrom i malnutricija jesu metabolicke abnormalnosti koje znacajno karakterisu bolesnike na hemodijalizi. Cilj rada bio je da se utvrdi incidencija i odrede karakteristike metabolickih disbalansa bolesnika na hemodijalizi. Metode. Studija je obuhvatila 124 bolesnika koji se lece hronicnim hemodijalizama u Klinickom centru Kragujevac. Analizirane su demografske i antropometrijske karakteristike ispitanika. Od klinickih karakteristika odredjivana je navika pusenja cigareta, duzina dijaliziranja, arterijski pritisak i prisustvo kardioloskih oboljenja i dijabetes melitusa. Rutinske biohemijske analize radjene su standardnom laboratorijskom procedurom. Rezultati. Metabolicki sindrom utvrdjen je kod 29,8% ispitanika. Bolesnici sa metabolickim sindromom bili su stariji u odnosu na bolesnike bez metabolickog sindoma (58,45?12,91 vs 52,25?11,63 godina). Vrednosti sistolnog pritiska (143,88?19,75 vs 133,01?22,93 mmHg; p = 0,014), indeksa telesne mase (21,2?3,71 vs 19,4?2,88 kg/m2; p = 0,001), masna masa tela (19,57?8,47 vs 16,45?5,82%; p = 0,0002) i obima struka (89?12,59 vs 96?12,34 cm; p = 0,0001) znacajno su vise kod bolesnika sa metabolickim sindromom u odnosu na bolesnike bez metabolickog sindroma. Eritrociti (3,4?0,45 vs 19?0,53 1012/l; p = 0,04), hemoglobin (107?15,76 vs 101?13,87 g/l; p = 0,009), glikemija (9,5?8,15 vs 5,6?1,4 mmol/l; p = 0,04), trigliceridi (2,44?1,8 vs 1,41?0,64 mmol/l; p = 0,007), HDL holesterol (1,11?0,19 vs 0,82?0,25 mmol/l; p = 0,005) i albumini (32,5?5,6 vs 29,5?3,7 g/l; p = 0,007) imali su statisticki znacajno vece vrednosti kod ispitanika sa metabolickim sindromom u odnosu na bolesnike bez ovog poremecaja. U grupi ispitanika sa metabolickim sindromom 21,6% imalo je dijabetes melitus kao etioloski faktor bubrezne insuficijencije, a kod bolesnika bez elemenata za ovu metabolicku abnormalnost, njih 5,7%; ta razlika bila je statisticki znacajna (p = 0,008). Zakljucak. U nasem istrazivanju jedna trecina hemodijaliznih bolesnika ima izrazen metabolicki sindrom, medju kojima dominiraju stariji, gojazni muskarci koji imaju vecu koncentraciju triglicerida i vise vrednosti glikemije. Kod ovih bolesnika dijabetska nefropatije je najznacajnija etioloska kategorija terminalne bubrezne insuficijencije.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP0803205S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2008
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 7
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    Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis
    National Library of Serbia ; 2010
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 67, No. 11 ( 2010), p. 916-922
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 67, No. 11 ( 2010), p. 916-922
    Abstract: Uvod/Cilj. Endotel krvnih sudova ima veliki znacaj u procesu aterogeneze. Cilj ovog rada bio je da se utvrdi korelacija endotelne disfunkcije i ateroskleroze kod bolesnika na hemodijalizi. Metode. Studija je organizovana kao klinicka i nerandomizirana, u periodu 2004-2008. godine u Centru za hemodijalizu Klinickog centra 'Kragujevac'. Analizirane su demografske karakteristike, pusenje, duzina trajanja hemodijalize, mekotkivne kalcifikacije i dopler ultrazvucni parametri karotidnih arterija. Evidentirani su svi letalni ishodi, uzrok i vreme smrti. Rezultati. Kod muskaraca zabelezen je statisticki znacajno siri precnik karotidnih arterija u odnosu na zene. Pozitivna korelacija postignuta je izmedju povrsine poprecnog preseka i debljine intime medije (r = 0,913; p 〈 0,0001), kao i precnika karotidnih arterija (r = 0,527; p 〈 0,0001). Holesterol negativno utice na precnik karotidnih arterija (r = -0,278; p = 0,019). I trigliceridi negativno korelisu sa povrsinom poprecnog preseka intime medije (r = -0,261; p = 0,028). Pozitivna korelacija utvrdjena je izmedju nivoa ukupnih proteina u serumu i precnika lumena karotidnih arterija (r = 0,235; p = 0,047), povrsine poprecnog preseka intime medije (r = 0,269; p = 0,022) i holesterola (r = 0,248; p = 0,037). Duzina dijaliziranja ima negativnu korelaciju sa precnikom karotidne arterije (r = -0,241; p = 0,04), a starost pozitivno korelise sa intimom medijom (r = 0,295; p = 0,013), dijametrom lumena (r = 0,296; p = 0,012) i povrsinom poprecnog preseka intime medije (r = 0,347; p = 0,003). Regresiona analiza ukazuje na prediktivni znacaj precnika lumena karotidnih arterija za prezivljavanje (Beta = 0,437; p = 0,011) ispitivanih bolesnika. Kumulativna stopa prezivljavanja u nasoj studiji bila je 57,5%. Zakljucak. Starost pacijenata pozitivno korelise sa svim parametrima ateroskleroze. Prosecno trajanje dijalize negativno korelise sa precnikom karotidnih arterija koji je veci kod muskaraca. Sto je precnik karotidnih arterija veci, prezivljavanje bolesnika na hemodijalizi je kraci.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP1011916S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2010
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 8
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    Association of metabolic changes with mortality of patients treated by peritoneal dialysis or hemodialysis
    Informa UK Limited ; 2010
    In:  Renal Failure Vol. 32, No. 7 ( 2010-08), p. 778-783
    Details
    In: Renal Failure, Informa UK Limited, Vol. 32, No. 7 ( 2010-08), p. 778-783
    Type of Medium: Online Resource
    ISSN: 0886-022X , 1525-6049
    URL: Article
    DOI: 10.3109/0886022X.2010.489168
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2015459-8
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  • 9
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    Early pathohistological changes in dysfunction of arteriovenous fistula for hemodialysis
    National Library of Serbia ; 2010
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 67, No. 1 ( 2010), p. 65-68
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 67, No. 1 ( 2010), p. 65-68
    Abstract: Uvod. Kod bolesnika na hemodijalizi neointimalna hiperplazija vodeci je faktor rizika od nastanka disfunkcije ateriovenske fistule. Ovaj proces podrazumeva proliferaciju glatkih misicnih celija iz medije u intimu. Prikaz bolesnika. Prikazan je bolesnik, star 76 godina, kod koga je doslo do tromboze fistule nakon inicijalne funkcije, osmog dana, bez prisustva poznatih faktora rizika. Histopatoloski nalaz ukazivao je na znacajnu formu procesa neointimalne proliferacije koja je dovela do stenoze i tromboze fistule. Zakljucak. Rane patohistoloske promene izrazene kod disfunkcije arteriovenske fistule za hemodijalizu reakcija su na izmenjene hemodinamske uslove.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP1001065S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2010
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 10
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    Intima-media thickness of carotid arteries and erectile dysfunction in hemodialysis patients : Prevalence and determinants of erectile dysfunction
    Wiley ; 2010
    In:  Hemodialysis International Vol. 14, No. 4 ( 2010-10), p. 510-514
    Details
    In: Hemodialysis International, Wiley, Vol. 14, No. 4 ( 2010-10), p. 510-514
    Type of Medium: Online Resource
    ISSN: 1492-7535
    URL: Issue
    URL: Article
    DOI: 10.1111/hdi.2010.14.issue-4
    DOI: 10.1111/j.1542-4758.2010.00493.x
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2103570-2
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