In:
The EMBO Journal, EMBO, Vol. 41, No. 23 ( 2022-12)
Abstract:
image How mammalian SWI/SNF/BAF chromatin remodeling complexes transcriptionally mediate their involvement in neurogenesis or gliogenesis is not fully understood. Here, a BCL7A‐containing complex is found to transcriptionally modulate mitochondria‐driven differentiation of neural progenitor cells (NPCs). The SWI/SNF/BAF complex subunit BCL7A is highly expressed in both NPCs and neurons. BCL7A‐containing SWI/SNF/BAF complexes promote transcriptional neurogenic profiles in differentiating NPCs. BCL7A loss skews NPC specification toward glial differentiation in vitro and in vivo . BCL7A promotes neural lineage determination by regulating Notch/Wnt signaling and mitochondrial bioenergetics. BCL7A enhances the genome‐wide occupancy of the ATPase BRG1.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022110595
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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