In:
Respiration, S. Karger AG, Vol. 82, No. 6 ( 2011), p. 530-538
Abstract:
〈 i 〉 Background: 〈 /i 〉 Cross-sectional studies have demonstrated that increased levels of interleukin-6 (IL6) are present in the airways and blood samples of patients with chronic obstructive pulmonary disease (COPD). 〈 i 〉 Objectives: 〈 /i 〉 To investigate the association between IL6 and the risk of COPD using a Mendelian randomization approach. 〈 i 〉 Methods: 〈 /i 〉 Eight common single-nucleotide polymorphisms (SNPs) in the region of the 〈 i 〉 IL6 〈 /i 〉 gene were genotyped using both TaqMan and Illumina in the Rotterdam Study, a prospective population-based cohort study consisting of 7,983 participants aged 55 years or older, including 928 COPD patients. At baseline, blood was drawn in a random sample of 714 subjects to measure the IL6 plasma level. Analysis of variance, logistic regression, and Cox proportional hazard models – adjusted for age, gender, pack years, and BMI – were used for analyses. 〈 i 〉 Results: 〈 /i 〉 High levels of IL6 ( 〉 2.4 pg/ml, the highest tertile) were associated with a three-fold increased risk of developing COPD, in comparison to low levels ( 〈 1.4 pg/ml, the lowest tertile). The rs2056576 SNP was associated with a 10% increase in the risk of COPD per additional T allele. However, the association was no longer significant after adjustment. No association was found with other common SNPs in the 〈 i 〉 IL6 〈 /i 〉 gene and COPD. 〈 i 〉 Conclusions: 〈 /i 〉 Although increased IL6 plasma levels at baseline are associated with the risk of developing COPD during follow-up, there was no strong evidence for an association between common variation in the 〈 i 〉 IL6 〈 /i 〉 gene and the risk of COPD.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1464419-8
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