In:
BMC Endocrine Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-08-09)
Abstract:
To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature. Methods This real-world study enrolled children with short stature in 19 hospitals throughout China. They were treated with PEG-rhGH for 6 months. The starting dosage ranged from 0.10 to 0.20 mg/kg/week. The primary outcome was the change in height standard deviation score (ΔHt SDS). Results Five hundred and ten patients were included and grouped based on dosage as A (0.10–0.14 mg/kg/week), B (0.15–0.16 mg/kg/week), C (0.17–0.19 mg/kg/week), and D (0.20 mg/kg/week). The mean 6-month ΔHt SDS for the total cohort was 0.49 ± 0.27, and the means differed among the four dose groups ( P = 0.002). The ΔHt SDS was lower in group A than in groups B (LSM difference [95%CI], -0.09 [-0.17, -0.01] ), C (LSM difference [95%CI], -0.10 [-0.18, -0.02] ), and D (LSM difference [95%CI], -0.13 [-0.21, -0.05] ) after adjusting baseline covariates. There were no significant differences among groups B, C, and D. When the baseline IGF-1 was 〈 -2 SDS or 〉 0 SDS, the △Ht SDS was not different among the four groups ( P = 0.931 and P = 0.400). In children with baseline IGF-1 SDS of -2 ~ 0 SDS, a higher dosage was associated with a better treatment effect ( P = 0.003), and the △Ht SDS was lower in older children than in younger ones ( P 〈 0.001). Conclusions PEG-rhGH could effectively increase height in prepubertal short children. When the baseline IGF-1 was 〈 -2 SDS, 0.10 mg/kg/week could be a starting dose. In other IGF-1 statuses, 0.15–0.20 mg/kg/week might be preferred. Trial registration ClinicalTrials.gov: NCT03249480 , retrospectively registered.
Type of Medium:
Online Resource
ISSN:
1472-6823
DOI:
10.1186/s12902-022-01101-8
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2091323-0
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