In:
Journal of Neuroimaging, Wiley, Vol. 25, No. 2 ( 2015-03), p. 175-183
Abstract:
Amygdala enlargement (AE) has been reported as an epileptogenic focus in subtypes of temporal lobe epilepsy (TLE). The purpose of this study was to investigate the clinical, morphological, and pathological characteristics of AE. METHODS We retrospectively reviewed the clinical data and imaging findings of 23 TLE patients with ipsilateral AE. We performed morphological MR analyses using FreeSurfer and voxel‐based morphometry (VBM) in 14 of the 23 patients and in 20 controls whose images were obtained by a 3.0‐Tesla MRI. A pathological study was also performed in 2 patients who underwent operations. RESULTS All patients became seizure free or shSowed dramatic improvement by medical therapy except for two. They received operations and their pathology revealed that both patients had cortical dysplasia in from the amygdala to the ipsilateral temporal pole. The FreeSurfer analysis showed a significant difference in the amygdala volumes between the affected and nonaffected sides. VBM revealed significant increases of gray matter volumes of the temporal pole on the side of AE in seven of the 14 patients with AE (50%). CONCLUSIONS Cortical dysplasia may be one of the pathological diagnoses in AE, and in some patients it may extend to the temporal pole.
Type of Medium:
Online Resource
ISSN:
1051-2284
,
1552-6569
DOI:
10.1111/jon.2015.25.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2035400-9
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