In:
EMBO reports, EMBO, Vol. 24, No. 9 ( 2023-09-06)
Abstract:
image CST plays a crucial role in engaging RECQ4 with telomeres, enabling efficient resolution of G4 structures and restarting stalled replication forks. Their cooperative action addresses G4‐induced replication challenges, preserving genomic stability and homeostasis. RECQ4 and CST interact to unwind G4s, thereby resolving replication challenges and maintaining genomic stability. Depletion of RECQ4 leads to G4 accumulation at telomeres, resulting in telomere dysfunction. CST is essential for stabilizing RECQ4 at telomeres, irrespective of telomerase presence.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202255494
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12
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