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Palliative Short-course Radiotherapy in Advanced Pelvic Cancer: A Phase II Study (SHARON Project)

FARINA, ELEONORA ; MACCHIA, GABRIELLA ; SIEPE, GIAMBATTISTA ; [et al.]

Anticancer Research USA Inc. ; 2019

In: Anticancer Research Vol. 39, No. 8 ( 2019-08), p. 4237-4242

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In: Anticancer Research, Anticancer Research USA Inc., Vol. 39, No. 8 ( 2019-08), p. 4237-4242

Type of Medium: Online Resource

ISSN: 0250-7005 , 1791-7530

URL: Article

DOI: 10.21873/anticanres.13585

RVK:

XA 10000

Language: English

Publisher: Anticancer Research USA Inc.

Publication Date: 2019

detail.hit.zdb_id: 2145376-7

detail.hit.zdb_id: 604549-2

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Cervical Cancer in Bangladesh

Uddin, A.F.M. Kamal ; Sumon, Mostafa Aziz ; Pervin, Shahana ; [et al.]

Georg Thieme Verlag KG ; 2023

In: South Asian Journal of Cancer Vol. 12, No. 01 ( 2023-01), p. 036-038

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In: South Asian Journal of Cancer, Georg Thieme Verlag KG, Vol. 12, No. 01 ( 2023-01), p. 036-038

Type of Medium: Online Resource

ISSN: 2278-330X , 2278-4306

URL: Article

DOI: 10.1055/s-0043-1764202

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2023

detail.hit.zdb_id: 2719571-5

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Radiotherapy for Advanced Esophageal Cancer: from Palliation to Curation

Xin, Zhuocheng ; Liu, Qi ; Ai, Dashan ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Current Treatment Options in Oncology

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In: Current Treatment Options in Oncology, Springer Science and Business Media LLC

Type of Medium: Online Resource

ISSN: 1527-2729 , 1534-6277

URL: Article

DOI: 10.1007/s11864-023-01134-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2090563-4

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Short course accelerated radiation therapy (SHARON) in palliative treatment of advanced solid cancer in older patients: A pooled analysis

Farina, Eleonora ; Capuccini, Jenny ; Macchia, Gabriella ; [et al.]

Elsevier BV ; 2018

In: Journal of Geriatric Oncology Vol. 9, No. 4 ( 2018-07), p. 359-361

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In: Journal of Geriatric Oncology, Elsevier BV, Vol. 9, No. 4 ( 2018-07), p. 359-361

Type of Medium: Online Resource

ISSN: 1879-4068

URL: Article

DOI: 10.1016/j.jgo.2018.01.004

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2556813-9

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Radiotherapy in palliation of thoracic tumors: a phase I–II study (SHARON project)

Farina, Eleonora ; Macchia, Gabriella ; Buwenge, Milly ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Clinical & Experimental Metastasis Vol. 35, No. 8 ( 2018-12), p. 739-746

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In: Clinical & Experimental Metastasis, Springer Science and Business Media LLC, Vol. 35, No. 8 ( 2018-12), p. 739-746

Type of Medium: Online Resource

ISSN: 0262-0898 , 1573-7276

URL: Article

DOI: 10.1007/s10585-018-9942-6

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 1496876-9

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Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh

Akter, Afroza ; Ahmed, Tasnuva ; Tauheed, Imam ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Neglected Tropical Diseases Vol. 16, No. 1 ( 2022-1-4), p. e0010102-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2022-1-4), p. e0010102-

Abstract: COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal and devastating outcome in many cases. In this study, we have compared the clinical, biochemical and immunological parameters across the different disease spectrum of COVID-19 in Bangladeshi patients. Methodology/Principal findings This longitudinal study was conducted in two COVID-19 hospitals and also around the community in Dhaka city in Bangladesh between November 2020 to March 2021. A total of 100 patients with COVID-19 infection were enrolled and classified into asymptomatic, mild, moderate and severe cases (n = 25/group). In addition, thirty age and sex matched healthy participants were enrolled and 21 were analyzed as controls based on exclusion criteria. After enrollment (study day1), follow-up visits were conducted on day 7, 14 and 28 for the cases. Older age, male gender and co-morbid conditions were the risk factors for severe COVID-19 disease. Those with moderate and severe cases of infection had low lymphocyte counts, high neutrophil counts along with a higher neutrophil-lymphocyte ratio (NLR) at enrollment; this decreased to normal range within 42 days after the onset of symptom. At enrollment, D-dimer, CRP and ferritin levels were elevated among moderate and severe cases. The mild, moderate, and severe cases were seropositive for IgG antibody by day 14 after enrollment. Moderate and severe cases showed significantly higher IgM and IgG levels of antibodies to SARS-CoV-2 compared to mild and asymptomatic cases. Conclusion/Significance We report on the clinical, biochemical, and hematological parameters associated with the different severity of COVID-19 infection. We also show different profile of antibody response against SARS-CoV-2 in relation to disease severity, especially in those with moderate and severe disease manifestations compared to the mild and asymptomatic infection.

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0010102

DOI: 10.1371/journal.pntd.0010102.g001

DOI: 10.1371/journal.pntd.0010102.g002

DOI: 10.1371/journal.pntd.0010102.g003

DOI: 10.1371/journal.pntd.0010102.g004

DOI: 10.1371/journal.pntd.0010102.g005

DOI: 10.1371/journal.pntd.0010102.t001

DOI: 10.1371/journal.pntd.0010102.t002

DOI: 10.1371/journal.pntd.0010102.t003

DOI: 10.1371/journal.pntd.0010102.t004

DOI: 10.1371/journal.pntd.0010102.s001

DOI: 10.1371/journal.pntd.0010102.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2429704-5

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Three dimensional conformal radiotherapy for synchronous bilateral breast irradiation using a mono iso-center technique

Mani, Karthick Raj ; Basu, Saumen ; Bhuiyan, Md Anisuzzaman ; [et al.]

Walter de Gruyter GmbH ; 2017

In: Polish Journal of Medical Physics and Engineering Vol. 23, No. 2 ( 2017-6-27), p. 15-19

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In: Polish Journal of Medical Physics and Engineering, Walter de Gruyter GmbH, Vol. 23, No. 2 ( 2017-6-27), p. 15-19

Abstract: Objective: The purpose of this study is to demonstrate the synchronous bilateral breast irradiation radiotherapy technique using a single isocenter. Materials and Methods: Six patients of synchronous bilateral breast were treated with single isocenter technique from February 2011 to June 2016. All the patients underwent a CT-simulation using appropriate positioning device. Target volumes and critical structures like heart, lung, esophagus, thyroid, etc., were delineated slice by slice in the CT data. An isocenter was placed above the sternum on the skin and both medial tangential and lateral tangential of the breast / chest wall were created using asymmetrical jaws to avoid the beam divergence through the lung and heart. The field weighting were adjusted manually to obtain a homogenous dose distribution. The planning objectives were to deliver uniform doses around the target and keep the doses to the organ at risk within the permissible limit. The beam energy of 6 MV or combination of 6 MV and 15 MV photons were used in the tangential fields according to the tangential separation. Boluses were used for all the mastectomy patients to increase the doses on the chest wall. In addition to that enhanced dynamic wedge and field in field technique were also used to obtain a homogenous distribution around the target volume and reduce the hot spots. The isocenter was just kept on the skin, such that the beam junctions will be overlapped only on the air just above the sternum. Acute toxicity during the treatment and late toxicity were recorded during the patient’s follow-up. Results: During the radiotherapy treatment follow-up there were no acute skin reactions in the field junctions, but one patient had grade 1 esophagitis and two patients had grade 2 skin reactions in the chest wall. With a median follow-up of 38.5 months (range: 8 - 49 months), no patients had a local recurrence, but one patients with triple negative disease had a distant metastases in brain and died after 28 months. Conclusions: We were able to successfully treat the synchronous bilateral breast using single isocenter radiotherapy while keeping the lung and heart doses within the acceptable dose limits. During the treatment follow-up there were no symptoms of acute skin reactions in the field junction.

Type of Medium: Online Resource

ISSN: 1898-0309

URL: Article

DOI: 10.1515/pjmpe-2017-0004

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2017

detail.hit.zdb_id: 2503818-7

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Image_6.tif

Bhuiyan, Taufiqur Rahman ; Al Banna, Hasan ; Kaisar, M. Hasanul ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Immunology Vol. 13 ( 2022-9-28)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-9-28)

Abstract: Coronavirus disease 2019 (COVID-19) is a protean disease causing different degrees of clinical severity including fatality. In addition to humoral immunity, antigen-specific T cells may play a critical role in defining the protective immune response against SARS-CoV-2, the virus that causes this disease. As a part of a longitudinal cohort study in Bangladesh to investigate B and T cell-specific immune responses, we sought to evaluate the activation-induced marker (AIM) and the status of different immune cell subsets during a COVID-19 infection. We analyzed a total of 115 participants, which included participants with asymptomatic, mild, moderate, and severe clinical symptoms. We observed decreased mucosal-associated invariant T (MAIT) cell frequency on the initial days of the COVID-19 infection in symptomatic patients compared to asymptomatic patients. However, natural killer (NK) cells were found to be elevated in symptomatic patients just after the onset of the disease compared to both asymptomatic patients and healthy individuals. Moreover, we found a significant increase of AIM + (both OX40 + CD137 + and OX40 + CD40L + ) CD4 + T cells in moderate and severe COVID-19 patients in response to SARS-CoV-2 peptides (especially spike peptides) compared to pre-pandemic controls who are unexposed to SARS-CoV-2. Notably, we did not observe any significant difference in the CD8 + AIMs (CD137 + CD69 + ), which indicates the exhaustion of CD8 + T cells during a COVID-19 infection. These findings suggest that patients who recovered from moderate and severe COVID-19 were able to mount a strong CD4 + T-cell response against shared viral determinants that ultimately induced T cells to mount further immune responses to SARS-CoV-2.

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2022.929849

DOI: 10.3389/fimmu.2022.929849.s001

DOI: 10.3389/fimmu.2022.929849.s002

DOI: 10.3389/fimmu.2022.929849.s003

DOI: 10.3389/fimmu.2022.929849.s004

DOI: 10.3389/fimmu.2022.929849.s005

DOI: 10.3389/fimmu.2022.929849.s006

DOI: 10.3389/fimmu.2022.929849.s007

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2606827-8

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Presentation_1.pptx

Akhtar, Marjahan ; Basher, Salima Raiyan ; Nizam, Nuder Nower ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Immunology Vol. 13 ( 2022-12-12)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-12-12)

Abstract: The longevity of immune responses induced by different degrees of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provides information important to understanding protection against coronavirus disease 2019 (COVID-19). Here, we report the persistence of SARS-CoV-2 spike receptor-binding domain (RBD) specific antibodies and memory B cells recognizing this antigen in sequential samples from patients in Bangladesh with asymptomatic, mild, moderate and severe COVID-19 out to six months following infection. Since the development of long-lived memory B cells, as well as antibody production, is likely to be dependent on T helper (Th) cells, we also investigated the phenotypic changes of Th cells in COVID-19 patients over time following infection. Our results show that patients with moderate to severe COVID-19 mounted significant levels of IgG antibodies out to six months following infection, while patients with asymptomatic or mild disease had significant levels of IgG antibodies out to 3 months following infection, but these then fell more rapidly at 6 months than in patients with higher disease severity. Patients from all severity groups developed circulating memory B cells (MBCs) specific to SARS-CoV-2 spike RBD by 3 months following infection, and these persisted until the last timepoint measured at 6 months. A T helper cell response with an effector memory phenotype was observed following infection in all symptomatic patients, while patients with asymptomatic infection had no significant increases in effector Th1, Th2 and Th17 effector memory cell responses. Our results suggest that the strength and magnitude of antibody and memory B cells induced following SARS-CoV-2 infection depend on the severity of the disease. Polarization of the Th cell response, with an increase in Th effector memory cells, occurs in symptomatic patients by day 7 following infection, with increases seen in Th1, Th2, Th17 and follicular helper T cell subsets.

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2022.1052374

DOI: 10.3389/fimmu.2022.1052374.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2606827-8

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The Fatal Clinical Outcome of Severe COVID-19 in Hospitalized Patients: Findings from a Prospective Cohort Study in Dhaka, Bangladesh

Ahmed, Tasnuva ; Akter, Afroza ; Tauheed, Imam ; [et al.]

MDPI AG ; 2023

In: Medicina Vol. 59, No. 7 ( 2023-07-10), p. 1280-

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In: Medicina, MDPI AG, Vol. 59, No. 7 ( 2023-07-10), p. 1280-

Abstract: Background and Objectives: The morbidity and mortality associated with COVID-19 have burdened worldwide healthcare systems beyond their capacities, forcing them to promptly investigate the virus characteristics and its associated outcomes. This clinical analysis aimed to explore the key factors related to the fatal outcome of severe COVID-19 cases. Materials and Methods: Thirty-five adult severe COVID-19 patients were enrolled from two COVID-19 hospitals in Dhaka, Bangladesh. Clinical manifestation, comorbid conditions, medications, SARS-CoV-2 RT-PCR related cycle threshold (CT) value, hematology, biochemical parameters with SARS-CoV-2 specific IgG and IgM responses at enrollment were compared between the survivors and deceased participants. Results: Total 27 patients survived and 8 patients died within 3 months of disease onset. Deceased patients suffered longer from shortness of breath than the survived (p = 0.049). Among the severe cases, 62% of the deceased patients had multiple comorbid condition compared to 48% of those who survived. Interestingly, the anti-viral was initiated earlier among the deceased patients [median day of 1 (IQR: 0, 1.5) versus 6.5 (IQR: 6.25, 6.75)]. Most of the survivors (55%) received a combination of anticoagulant (p = 0.034). Liver enzymes, creatinine kinase, and procalcitonin were higher among the deceased patients during enrollment. The median CT value among the deceased was significantly lower than the survivors (p = 0.025). A significant difference for initial IgG (p = 0.013) and IgM (p = 0.030) responses was found between the survivor and the deceased groups. Conclusions: The factors including older age, male gender, early onset of respiratory distress, multiple comorbidities, low CT value, and poor antibody response may contribute to the fatal outcome in severe COVID-19 patients. Early initiation of anti-viral and a combination of anticoagulant treatment may prevent or lower the fatality among severe COVID-19 cases.

Type of Medium: Online Resource

ISSN: 1648-9144

URL: Article

DOI: 10.3390/medicina59071280

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 2088820-X

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