KOBV Portal

Online Resource

Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abani, O ; Abbas, A ; Abbas, F ; [et al.]

Elsevier BV ; 2023

In: The Lancet Diabetes & Endocrinology Vol. 11, No. 12 ( 2023-12), p. 905-914

add to watchlist on the watchlist

Details

In: The Lancet Diabetes & Endocrinology, Elsevier BV, Vol. 11, No. 12 ( 2023-12), p. 905-914

Type of Medium: Online Resource

ISSN: 2213-8587

URL: Article

DOI: 10.1016/S2213-8587(23)00253-X

Language: English

Publisher: Elsevier BV

Publication Date: 2023

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

Faust, Saul N ; Haynes, Richard ; Jones, Christine E ; [et al.]

Elsevier BV ; 2024

In: The Lancet Child & Adolescent Health Vol. 8, No. 3 ( 2024-03), p. 190-200

add to watchlist on the watchlist

Details

In: The Lancet Child & Adolescent Health, Elsevier BV, Vol. 8, No. 3 ( 2024-03), p. 190-200

Type of Medium: Online Resource

ISSN: 2352-4642

URL: Article

DOI: 10.1016/S2352-4642(23)00316-4

Language: English

Publisher: Elsevier BV

Publication Date: 2024

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Combining different design strategies for rational affinity maturation of the MICA‐NKG2D interface

Henager, Samuel H. ; Hale, Melissa A. ; Maurice, Nicholas J. ; [et al.]

Wiley ; 2012

In: Protein Science Vol. 21, No. 9 ( 2012-09), p. 1396-1402

add to watchlist on the watchlist

Details

In: Protein Science, Wiley, Vol. 21, No. 9 ( 2012-09), p. 1396-1402

Abstract: We redesigned residues on the surface of MICA, a protein that binds the homodimeric immunoreceptor NKG2D, to increase binding affinity with a series of rational, incremental changes. A fixed‐backbone RosettaDesign protocol scored a set of initial mutations, which we tested by surface plasmon resonance for thermodynamics and kinetics of NKG2D binding, both singly and in combination. We combined the best four mutations at the surface with three affinity‐enhancing mutations below the binding interface found with a previous design strategy. After curating design scores with three cross‐validated tests, we found a linear relationship between free energy of binding and design score, and to a lesser extent, enthalpy and design score. Multiple mutants bound with substantial subadditivity, but in at least one case full additivity was observed when combining distant mutations. Altogether, combining the best mutations from the two strategies into a septuple mutant enhanced affinity by 50‐fold, to 50 nM, demonstrating a simple, effective protocol for affinity enhancement.

Type of Medium: Online Resource

ISSN: 0961-8368 , 1469-896X

URL: Issue

URL: Article

DOI: 10.1002/pro.v21.9

DOI: 10.1002/pro.2115

RVK:

WA 15000

Language: English

Publisher: Wiley

Publication Date: 2012

detail.hit.zdb_id: 2000025-X

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

1 Route of admission in stemi: do patients who present directly to a PCI-capable hospital differ from inter-hospital transfers?

Austin, D. ; Adam, Z. ; Shome, J. ; [et al.]

BMJ ; 2011

In: Heart Vol. 97, No. Suppl 1 ( 2011-06-01), p. A5-A5

add to watchlist on the watchlist

Details

In: Heart, BMJ, Vol. 97, No. Suppl 1 ( 2011-06-01), p. A5-A5

Type of Medium: Online Resource

ISSN: 1355-6037

URL: Article

DOI: 10.1136/heartjnl-2011-300198.1

Language: English

Publisher: BMJ

Publication Date: 2011

detail.hit.zdb_id: 1475501-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Conserved Modular Domains Team up to Latch-open Active Protein Kinase Cα

Swanson, Carter J. ; Ritt, Michael ; Wang, William ; [et al.]

Elsevier BV ; 2014

In: Journal of Biological Chemistry Vol. 289, No. 25 ( 2014-06), p. 17812-17829

add to watchlist on the watchlist

Details

In: Journal of Biological Chemistry, Elsevier BV, Vol. 289, No. 25 ( 2014-06), p. 17812-17829

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M113.534750

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

30 Do PRAMI and CVLPRIT represent real-life experiences of culprit-only PPCI? - a single centre observational study

Jackson, M ; Austin, D ; Hall, J ; [et al.]

BMJ ; 2016

In: Heart Vol. 102, No. Suppl 4 ( 2016-05), p. A13.3-A14

add to watchlist on the watchlist

Details

In: Heart, BMJ, Vol. 102, No. Suppl 4 ( 2016-05), p. A13.3-A14

Type of Medium: Online Resource

ISSN: 1355-6037 , 1468-201X

URL: Article

DOI: 10.1136/heartjnl-2016-309588.30

Language: English

Publisher: BMJ

Publication Date: 2016

detail.hit.zdb_id: 2378689-9

detail.hit.zdb_id: 1475501-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Non-Canonical Modular Domain Interactions Dictate PKCα Function

Swanson, Carter J. ; Ritt, Michael ; Wang, William ; [et al.]

Elsevier BV ; 2014

In: Biophysical Journal Vol. 106, No. 2 ( 2014-01), p. 467a-

add to watchlist on the watchlist

Details

In: Biophysical Journal, Elsevier BV, Vol. 106, No. 2 ( 2014-01), p. 467a-

Type of Medium: Online Resource

ISSN: 0006-3495

URL: Article

DOI: 10.1016/j.bpj.2013.11.2643

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 1477214-0

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

029 Management and outcomes of patients following out-of-hospital cardiac arrest

Khan, S ; Saidmeerasah, A ; Hunjan, R ; [et al.]

BMJ ; 2012

In: Heart Vol. 98, No. Suppl 1 ( 2012-05), p. A19.2-A20

add to watchlist on the watchlist

Details

In: Heart, BMJ, Vol. 98, No. Suppl 1 ( 2012-05), p. A19.2-A20

Type of Medium: Online Resource

ISSN: 1355-6037 , 1468-201X

URL: Article

DOI: 10.1136/heartjnl-2012-301877b.29

Language: English

Publisher: BMJ

Publication Date: 2012

detail.hit.zdb_id: 2378689-9

detail.hit.zdb_id: 1475501-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

040 Twelve lead electrocardiographic criteria for reperfusion therapy in ST elevation myocardial infarction: need for reappraisal with the advent of primary percutaneous coronary intervention?

Adam, Z ; Kumar, N ; Matthews, I G ; [et al.]

BMJ ; 2010

In: Heart Vol. 96, No. Suppl 1 ( 2010-06), p. A24.1-A24

add to watchlist on the watchlist

Details

In: Heart, BMJ, Vol. 96, No. Suppl 1 ( 2010-06), p. A24.1-A24

Type of Medium: Online Resource

ISSN: 1355-6037 , 1468-201X

URL: Article

DOI: 10.1136/hrt.2010.195958.14

Language: English

Publisher: BMJ

Publication Date: 2010

detail.hit.zdb_id: 2378689-9

detail.hit.zdb_id: 1475501-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Calcium Stimulates Self-Assembly of Protein Kinase C α In Vitro

Swanson, Carter J. ; Sommese, Ruth F. ; Petersen, Karl J. ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS ONE Vol. 11, No. 10 ( 2016-10-5), p. e0162331-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 10 ( 2016-10-5), p. e0162331-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0162331

DOI: 10.1371/journal.pone.0162331.g001

DOI: 10.1371/journal.pone.0162331.g002

DOI: 10.1371/journal.pone.0162331.g003

DOI: 10.1371/journal.pone.0162331.g004

DOI: 10.1371/journal.pone.0162331.g005

DOI: 10.1371/journal.pone.0162331.g006

DOI: 10.1371/journal.pone.0162331.g007

DOI: 10.1371/journal.pone.0162331.s001

DOI: 10.1371/journal.pone.0162331.s002

DOI: 10.1371/journal.pone.0162331.s003

DOI: 10.1371/journal.pone.0162331.s004

DOI: 10.1371/journal.pone.0162331.s005

DOI: 10.1371/journal.pone.0162331.s006

DOI: 10.1371/journal.pone.0162331.s007

DOI: 10.1371/journal.pone.0162331.s008

DOI: 10.1371/journal.pone.0162331.s009

DOI: 10.1371/journal.pone.0162331.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 94 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg