In:
Kidney and Blood Pressure Research, S. Karger AG, Vol. 31, No. 1 ( 2008), p. 47-54
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome. 〈 i 〉 Methods: 〈 /i 〉 In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively). 〈 i 〉 Results: 〈 /i 〉 Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p 〈 0.001) and correlated with serum total protein (r = –0.549, p 〈 0.001), serum albumin (r = –0.596, p 〈 0.001), proteinuria (r = 0.456, p 〈 0.001) and serum total cholesterol (r = 0.523, p 〈 0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p 〈 0.001). Serum LDH-2 activity correlated with serum total protein (r = –0.665, p 〈 0.001), serum albumin (r = –0.615, p 〈 0.001), proteinuria (r = 0.694, p 〈 0.001), and serum total cholesterol (r = 0.723, p 〈 0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2. 〈 i 〉 Conclusions: 〈 /i 〉 These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome.
Type of Medium:
Online Resource
ISSN:
1420-4096
,
1423-0143
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482922-8
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