In:
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society, Vol. 99, No. 12 ( 2014-12-01), p. E2485-E2493
Abstract:
To the best of our knowledge, no study has examined the effects of vitamin D-calcium cosupplementation on inflammatory biomarkers and adipocytokines in vitamin D-insufficient type 2 diabetics. Objective: This study was performed to assess the effects of vitamin D and calcium supplementation on inflammatory biomarkers and adipocytokines in vitamin D-insufficient people with type 2 diabetes. Methods: Totally, 118 diabetic patients were enrolled in this randomized, placebo-controlled clinical trial. After matching for age, sex, body mass index, type and dose of hypoglycemic agents, and duration of diabetes, subjects were randomly assigned into 4 groups receiving the following: 1) 50000 IU/wk vitamin D + calcium placebo; 2) 1000 mg/d calcium + vitamin D placebo; 3) 50 000 IU/wk vitamin D + 1000 mg/d calcium; or 4) vitamin D placebo + calcium placebo for 8 weeks. Blood sampling was done for the quantification of inflammatory biomarkers and adipocytokines at the study baseline and after 8 weeks of intervention. Results: Calcium (changes from baseline: −75±19 ng/ml, P = .01) and vitamin D alone (−56 ± 19 ng/mL, P = .01) and joint calcium-vitamin D supplementation (−92 ± 19 ng/mL, P = .01) resulted in a significant reduction in serum leptin levels compared with placebo (−9 ± 18 ng/mL). This was also the case for serum IL-6, such that calcium (−2 ± 1 pg/mL, P & lt; .001) and vitamin D alone (−4 ± 1 pg/mL, P & lt; .001) and their combination (−4 ± 1 pg/mL, P & lt; .001) led to significant reductions compared with placebo (3 ± 1 pg/mL). After adjustment for potential confounders, individuals in the calcium (−3.1 ± 1.3, P & lt; .05), vitamin D (−3.1 ± 1.3, P & lt; .05), and joint calcium-vitamin D groups (−3.4 ± 1.3, P & lt; .05) had greater reductions in serum TNF-α concentrations compared with placebo (0.1 ± 1.2). Individuals who received joint calcium-vitamin D supplements tended to have a decrease in serum high-sensitivity C-reactive protein levels compared with placebo after controlling for baseline levels (−1.14 ± 0.25 vs 0.02 ± 0.24 ng/mL, P = .09). Conclusion: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-α concentrations in vitamin D-insufficient people with type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
0021-972X
,
1945-7197
DOI:
10.1210/jc.2014-1977
Language:
English
Publisher:
The Endocrine Society
Publication Date:
2014
detail.hit.zdb_id:
2026217-6
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