In:
FEBS Letters, Wiley, Vol. 425, No. 2 ( 1998-03-27), p. 329-336
Abstract:
A series of truncated dystrophin cDNAs (3.1–4.2 kbp) containing only three, three, two or one rod repeats with hinge 1 and 4 (named ΔDysAX2, AX11, AH3, M3, respectively) or no rod repeat retaining either hinge 1 or 4 (named ΔDysH1, H4, respectively) were constructed. These cDNAs were introduced into skeletal muscle of adult mdx mice using the adenovirus vector with a strong CAG promoter. ΔDysAX2, AX11, AH3 and ΔDysM3 expressed themselves successfully and recovered dystrophin‐associated proteins effectively. Especially 3.7 kbp cDNA for ΔDysM3 offers the possibility of an approach utilizing newly developed virus vectors, such as an adeno‐associated virus vector, toward gene therapy of Duchenne muscular dystrophy.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(98)00251-8
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
1460391-3
SSG:
12
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