In:
Congenital Anomalies, Wiley, Vol. 46, No. 4 ( 2006-12), p. 188-193
Abstract:
ABSTRACT Rats of the Jcl: Wistar‐TgN (ARGHGEN) 1Nts strain (Mini rats) are transgenic animals carrying an antisense RNA transgene for rat growth hormone (GH); they show poor somatic growth and a low blood GH level compared to age‐matched wild‐type Wistar (non‐Mini) rats. The purpose of the present study was to investigate age‐related changes in growth hormone‐immunoreactive (GH‐IR) cells in the anterior pituitary gland (AP) of Mini rats at four, six, and eight weeks of age. The body weight and size of the GH‐IR cells of Mini rats was significantly lower than that of non‐Mini rats at six and eight weeks of age; however, this difference was not observed at four weeks of age. The AP volume and the number of GH‐IR cells in Mini rats were significantly smaller than those of the age‐matched non‐Mini rats at the three ages. These results suggest that the abnormal development of GH‐IR cells in the AP induced by the GH antisense RNA transgene is responsible for the poor somatic growth and the low blood GH levels in Mini rats.
Type of Medium:
Online Resource
ISSN:
0914-3505
,
1741-4520
DOI:
10.1111/cga.2006.46.issue-4
DOI:
10.1111/j.1741-4520.2006.00127.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2139944-X
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