In:
Turkish Journal of Biochemistry, Walter de Gruyter GmbH, Vol. 46, No. 6 ( 2021-12-30), p. 721-727
Abstract:
The aim of the study is to analyze the association of different bitter and sweet gene receptor polymorphisms and bitter and sweet food consumption on formation of dental caries in Turkish adult population. Methods This study included 205 adults whose detailed intraoral health examination was completed and decayed, missing, filled teeth (DMFT) index values were recorded. A mini questionnaire was applied to assess the consumption of bitter and sweet food. A venous blood sample from each participant was collected in Ethylenediamine tetraacetic acid (EDTA) tubes. Further, DNA samples were isolated from the blood samples by utilizing a DNA isolation kit, which were stored at +4 °C prior to the analysis. Taste receptor type 2 member 38 ( TAS2R38 ; rs10246939, rs713598, rs1726866), Taste receptor type 1 member 2 ( TAS1R2 ; rs35874116, rs9701796), and Taste receptor type 1 member 3 ( TAS1R3 ; rs307355) gene polymorphisms were detected using real-time polymerase chain reaction (PCR). Results There was no statistically significant association between the TAS2R38 , TAS1R2 , and TAS1R3 gene polymorphism and the DMFT index (p 〉 0.05). No significant difference was found between the consumption of bitter and sweet food and the DMFT index (p 〉 0.05). Conclusions TAS2R38 (rs10246939, rs713598, rs1726866), TAS1R2 (rs35874116, rs9701796), and TAS1R3 (rs307355) gene polymorphism may not be associated with the formation of dental caries in the Turkish adult population.
Type of Medium:
Online Resource
ISSN:
1303-829X
DOI:
10.1515/tjb-2019-0153
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2021
detail.hit.zdb_id:
2244112-8
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